BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

324 related articles for article (PubMed ID: 33076974)

  • 1. Pharmacological intervention to restore connectivity deficits of neuronal networks derived from ASD patient iPSC with a TSC2 mutation.
    Alsaqati M; Heine VM; Harwood AJ
    Mol Autism; 2020 Oct; 11(1):80. PubMed ID: 33076974
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Biallelic Mutations in
    Winden KD; Sundberg M; Yang C; Wafa SMA; Dwyer S; Chen PF; Buttermore ED; Sahin M
    J Neurosci; 2019 Nov; 39(47):9294-9305. PubMed ID: 31591157
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Tuberous Sclerosis Complex (TSC) Inactivation Increases Neuronal Network Activity by Enhancing Ca
    Hisatsune C; Shimada T; Miyamoto A; Lee A; Yamagata K
    J Neurosci; 2021 Sep; 41(39):8134-8149. PubMed ID: 34417327
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Neuronal Tsc1/2 complex controls autophagy through AMPK-dependent regulation of ULK1.
    Di Nardo A; Wertz MH; Kwiatkowski E; Tsai PT; Leech JD; Greene-Colozzi E; Goto J; Dilsiz P; Talos DM; Clish CB; Kwiatkowski DJ; Sahin M
    Hum Mol Genet; 2014 Jul; 23(14):3865-74. PubMed ID: 24599401
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Purkinje cells derived from TSC patients display hypoexcitability and synaptic deficits associated with reduced FMRP levels and reversed by rapamycin.
    Sundberg M; Tochitsky I; Buchholz DE; Winden K; Kujala V; Kapur K; Cataltepe D; Turner D; Han MJ; Woolf CJ; Hatten ME; Sahin M
    Mol Psychiatry; 2018 Nov; 23(11):2167-2183. PubMed ID: 29449635
    [TBL] [Abstract][Full Text] [Related]  

  • 6. TSC patient-derived isogenic neural progenitor cells reveal altered early neurodevelopmental phenotypes and rapamycin-induced MNK-eIF4E signaling.
    Martin P; Wagh V; Reis SA; Erdin S; Beauchamp RL; Shaikh G; Talkowski M; Thiele E; Sheridan SD; Haggarty SJ; Ramesh V
    Mol Autism; 2020; 11(1):2. PubMed ID: 31921404
    [TBL] [Abstract][Full Text] [Related]  

  • 7. RHOA signaling defects result in impaired axon guidance in iPSC-derived neurons from patients with tuberous sclerosis complex.
    Catlett TS; Onesto MM; McCann AJ; Rempel SK; Glass J; Franz DN; Gómez TM
    Nat Commun; 2021 May; 12(1):2589. PubMed ID: 33972524
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Hepatitis C virus inhibits AKT-tuberous sclerosis complex (TSC), the mechanistic target of rapamycin (MTOR) pathway, through endoplasmic reticulum stress to induce autophagy.
    Huang H; Kang R; Wang J; Luo G; Yang W; Zhao Z
    Autophagy; 2013 Feb; 9(2):175-95. PubMed ID: 23169238
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Upregulation of 6-phosphofructo-2-kinase (PFKFB3) by hyperactivated mammalian target of rapamycin complex 1 is critical for tumor growth in tuberous sclerosis complex.
    Wang Y; Tang S; Wu Y; Wan X; Zhou M; Li H; Zha X
    IUBMB Life; 2020 May; 72(5):965-977. PubMed ID: 31958214
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Translatome analysis of tuberous sclerosis complex 1 patient-derived neural progenitor cells reveals rapamycin-dependent and independent alterations.
    Aksoylu IS; Martin P; Robert F; Szkop KJ; Redmond NE; Bhattacharyya S; Wang J; Chen S; Beauchamp RL; Nobeli I; Pelletier J; Larsson O; Ramesh V
    Mol Autism; 2023 Oct; 14(1):39. PubMed ID: 37880800
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The role of TSC1 and TSC2 proteins in neuronal axons.
    Karalis V; Wood D; Teaney NA; Sahin M
    Mol Psychiatry; 2024 Apr; 29(4):1165-1178. PubMed ID: 38212374
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Heterozygous inactivation of tsc2 enhances tumorigenesis in p53 mutant zebrafish.
    Kim SH; Kowalski ML; Carson RP; Bridges LR; Ess KC
    Dis Model Mech; 2013 Jul; 6(4):925-33. PubMed ID: 23580196
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Increased degradation of FMRP contributes to neuronal hyperexcitability in tuberous sclerosis complex.
    Winden KD; Pham TT; Teaney NA; Ruiz J; Chen R; Chen C; Sahin M
    Cell Rep; 2023 Aug; 42(8):112838. PubMed ID: 37494191
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A Farnesyltransferase Inhibitor Restores Cognitive Deficits in
    Sugiura H; Shimada T; Moriya-Ito K; Goto JI; Fujiwara H; Ishii R; Shitara H; Taya C; Fujii S; Kobayashi T; Hino O; Worley PF; Yamagata K
    J Neurosci; 2022 Mar; 42(12):2598-2612. PubMed ID: 35121635
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Tuberous sclerosis complex activity is required to control neuronal stress responses in an mTOR-dependent manner.
    Di Nardo A; Kramvis I; Cho N; Sadowski A; Meikle L; Kwiatkowski DJ; Sahin M
    J Neurosci; 2009 May; 29(18):5926-37. PubMed ID: 19420259
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Evaluation of Hsp90 and mTOR inhibitors as potential drugs for the treatment of TSC1/TSC2 deficient cancer.
    Mrozek EM; Bajaj V; Guo Y; Malinowska IA; Zhang J; Kwiatkowski DJ
    PLoS One; 2021; 16(4):e0248380. PubMed ID: 33891611
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A new homozygous HERC1 gain-of-function variant in MDFPMR syndrome leads to mTORC1 hyperactivation and reduced autophagy during cell catabolism.
    Schwarz JM; Pedrazza L; Stenzel W; Rosa JL; Schuelke M; Straussberg R
    Mol Genet Metab; 2020; 131(1-2):126-134. PubMed ID: 32921582
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Tsc2 mutation rather than Tsc1 mutation dominantly causes a social deficit in a mouse model of tuberous sclerosis complex.
    Kashii H; Kasai S; Sato A; Hagino Y; Nishito Y; Kobayashi T; Hino O; Mizuguchi M; Ikeda K
    Hum Genomics; 2023 Feb; 17(1):4. PubMed ID: 36732866
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Dampened VEPH1 activates mTORC1 signaling by weakening the TSC1/TSC2 association in hepatocellular carcinoma.
    Dong P; Wang X; Liu L; Tang W; Ma L; Zeng W; Sun S; Zhang L; Zhang N; Shen X; Janssen HLA; Dong L; Zhang S; Chen S
    J Hepatol; 2020 Dec; 73(6):1446-1459. PubMed ID: 32610114
    [TBL] [Abstract][Full Text] [Related]  

  • 20. PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress.
    Ranek MJ; Kokkonen-Simon KM; Chen A; Dunkerly-Eyring BL; Vera MP; Oeing CU; Patel CH; Nakamura T; Zhu G; Bedja D; Sasaki M; Holewinski RJ; Van Eyk JE; Powell JD; Lee DI; Kass DA
    Nature; 2019 Feb; 566(7743):264-269. PubMed ID: 30700906
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 17.