BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

125 related articles for article (PubMed ID: 33092905)

  • 1. Design and synthesis of novel fluorescently labeled analogs of vemurafenib targeting MKK4.
    Kircher T; Pantsar T; Oder A; Peter von Kries J; Juchum M; Pfaffenrot B; Kloevekorn P; Albrecht W; Selig R; Laufer S
    Eur J Med Chem; 2021 Jan; 209():112901. PubMed ID: 33092905
    [TBL] [Abstract][Full Text] [Related]  

  • 2. From off-to on-target: New BRAF-inhibitor-template-derived compounds selectively targeting mitogen activated protein kinase kinase 4 (MKK4).
    Klövekorn P; Pfaffenrot B; Juchum M; Selig R; Albrecht W; Zender L; Laufer SA
    Eur J Med Chem; 2021 Jan; 210():112963. PubMed ID: 33199152
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Design and synthesis of 1H-pyrazolo[3,4-b]pyridines targeting mitogen-activated protein kinase kinase 4 (MKK4) - A promising target for liver regeneration.
    Pfaffenrot B; Klövekorn P; Juchum M; Selig R; Albrecht W; Zender L; Laufer SA
    Eur J Med Chem; 2021 Jun; 218():113371. PubMed ID: 33794385
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Scaffold modified Vemurafenib analogues as highly selective mitogen activated protein kinase kinase 4 (MKK4) inhibitors.
    Juchum M; Pfaffenrot B; Klövekorn P; Selig R; Albrecht W; Zender L; Laufer SA
    Eur J Med Chem; 2022 Oct; 240():114584. PubMed ID: 35868124
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Docking-based structural splicing and reassembly strategy to develop novel deazapurine derivatives as potent B-Raf
    Wang GM; Wang X; Zhu JM; Guo BB; Yang Z; Xu ZJ; Li B; Wang HY; Meng LH; Zhu WL; Ding J
    Acta Pharmacol Sin; 2017 Jul; 38(7):1059-1068. PubMed ID: 28414204
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Discovery of Covalent MKK4/7 Dual Inhibitor.
    Jiang J; Jiang B; He Z; Ficarro SB; Che J; Marto JA; Gao Y; Zhang T; Gray NS
    Cell Chem Biol; 2020 Dec; 27(12):1553-1560.e8. PubMed ID: 32916088
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A fluorescence-based thermal shift assay identifies inhibitors of mitogen activated protein kinase kinase 4.
    Krishna SN; Luan CH; Mishra RK; Xu L; Scheidt KA; Anderson WF; Bergan RC
    PLoS One; 2013; 8(12):e81504. PubMed ID: 24339940
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Development of a non-radioactive, 384-well format assay to detect inhibitors of the mitogen-activated protein kinase kinase 4.
    Togame H; Fuchikami K; Sagara A; Inbe H; Ziegelbauer K
    Assay Drug Dev Technol; 2005 Feb; 3(1):65-76. PubMed ID: 15798397
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Mitochondrial complex I inhibitor deguelin induces metabolic reprogramming and sensitizes vemurafenib-resistant BRAF
    Carpenter EL; Chagani S; Nelson D; Cassidy PB; Laws M; Ganguli-Indra G; Indra AK
    Mol Carcinog; 2019 Sep; 58(9):1680-1690. PubMed ID: 31211467
    [TBL] [Abstract][Full Text] [Related]  

  • 10. A high-throughput screen reveals new small-molecule activators and inhibitors of pantothenate kinases.
    Sharma LK; Leonardi R; Lin W; Boyd VA; Goktug A; Shelat AA; Chen T; Jackowski S; Rock CO
    J Med Chem; 2015 Feb; 58(3):1563-8. PubMed ID: 25569308
    [TBL] [Abstract][Full Text] [Related]  

  • 11. 7-Azaindole: A Versatile Scaffold for Developing Kinase Inhibitors.
    Irie T; Sawa M
    Chem Pharm Bull (Tokyo); 2018; 66(1):29-36. PubMed ID: 29311509
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Live-cell imaging and profiling of c-Jun N-terminal kinases using covalent inhibitor-derived probes.
    Qian L; Pan S; Lee JS; Ge J; Li L; Yao SQ
    Chem Commun (Camb); 2019 Jan; 55(8):1092-1095. PubMed ID: 30620026
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Identification, structure modification, and characterization of potential small-molecule SGK3 inhibitors with novel scaffolds.
    Gong GQ; Wang K; Dai XC; Zhou Y; Basnet R; Chen Y; Yang DH; Lee WJ; Buchanan CM; Flanagan JU; Shepherd PR; Chen Y; Wang MW
    Acta Pharmacol Sin; 2018 Dec; 39(12):1902-1912. PubMed ID: 30038340
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Discovery and characterization of non-ATP site inhibitors of the mitogen activated protein (MAP) kinases.
    Comess KM; Sun C; Abad-Zapatero C; Goedken ER; Gum RJ; Borhani DW; Argiriadi M; Groebe DR; Jia Y; Clampit JE; Haasch DL; Smith HT; Wang S; Song D; Coen ML; Cloutier TE; Tang H; Cheng X; Quinn C; Liu B; Xin Z; Liu G; Fry EH; Stoll V; Ng TI; Banach D; Marcotte D; Burns DJ; Calderwood DJ; Hajduk PJ
    ACS Chem Biol; 2011 Mar; 6(3):234-44. PubMed ID: 21090814
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Identification, synthesis and evaluation of CSF1R inhibitors using fragment based drug design.
    Machiraju PK; Yedla P; Gubbala SP; Bohari T; Abdul JKV; Xu S; Patel R; Chittireddy VRR; Boppana K; Jagarlapudi SARP; Neamati N; Syed R; Amanchy R
    Comput Biol Chem; 2019 Jun; 80():374-383. PubMed ID: 31103918
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Small molecule inhibitors of IκB kinase β: A chip-based screening and molecular docking simulation.
    Cho YW; Lim HJ; Han MH; Kim BC; Han S
    Bioorg Med Chem; 2020 May; 28(9):115440. PubMed ID: 32205046
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Design and synthesis of novel 2,3-dihydropyrazino[1,2-a]indole-1,4-dione derivatives as antiproliferative EGFR and BRAF
    Al-Wahaibi LH; Gouda AM; Abou-Ghadir OF; Salem OIA; Ali AT; Farghaly HS; Abdelrahman MH; Trembleau L; Abdu-Allah HHM; Youssif BGM
    Bioorg Chem; 2020 Nov; 104():104260. PubMed ID: 32920363
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The first small molecules capable of strongly suppressing proliferation of cancer cells harboring BRAF class I/II/III mutations.
    Choi SH; Shin I; Kim N; Nam Y; Sim T
    Biochem Biophys Res Commun; 2020 Nov; 532(2):315-320. PubMed ID: 32873393
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Searching new structural scaffolds for BRAF inhibitors. An integrative study using theoretical and experimental techniques.
    Campos LE; Garibotto FM; Angelina E; Kos J; Tomašič T; Zidar N; Kikelj D; Gonec T; Marvanova P; Mokry P; Jampilek J; Alvarez SE; Enriz RD
    Bioorg Chem; 2019 Oct; 91():103125. PubMed ID: 31401373
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Fluorescence Polarization Screening Assays for Small Molecule Allosteric Modulators of ABL Kinase Function.
    Grover P; Shi H; Baumgartner M; Camacho CJ; Smithgall TE
    PLoS One; 2015; 10(7):e0133590. PubMed ID: 26222440
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.