BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

123 related articles for article (PubMed ID: 33124429)

  • 1. 5-Phenyl-1,3,4-oxadiazol-2(3
    Mahy W; Willis NJ; Zhao Y; Woodward HL; Svensson F; Sipthorp J; Vecchia L; Ruza RR; Hillier J; Kjær S; Frew S; Monaghan A; Bictash M; Salinas PC; Whiting P; Vincent JP; Jones EY; Fish PV
    J Med Chem; 2020 Nov; 63(21):12942-12956. PubMed ID: 33124429
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit.
    Willis NJ; Mahy W; Sipthorp J; Zhao Y; Woodward HL; Atkinson BN; Bayle ED; Svensson F; Frew S; Jeganathan F; Monaghan A; Benvegnù S; Jolly S; Vecchia L; Ruza RR; Kjær S; Howell S; Snijders AP; Bictash M; Salinas PC; Vincent JP; Jones EY; Whiting P; Fish PV
    J Med Chem; 2022 May; 65(10):7212-7230. PubMed ID: 35536179
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity.
    Steadman D; Atkinson BN; Zhao Y; Willis NJ; Frew S; Monaghan A; Patel C; Armstrong E; Costelloe K; Magno L; Bictash M; Jones EY; Fish PV; Svensson F
    J Med Chem; 2022 Jan; 65(1):562-578. PubMed ID: 34939789
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors.
    Atkinson BN; Steadman D; Mahy W; Zhao Y; Sipthorp J; Bayle ED; Svensson F; Papageorgiou G; Jeganathan F; Frew S; Monaghan A; Bictash M; Jones EY; Fish PV
    Bioorg Med Chem Lett; 2020 Feb; 30(3):126751. PubMed ID: 31862412
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling.
    Bayle ED; Svensson F; Atkinson BN; Steadman D; Willis NJ; Woodward HL; Whiting P; Vincent JP; Fish PV
    J Med Chem; 2021 Apr; 64(8):4289-4311. PubMed ID: 33783220
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Small-molecule inhibitors of carboxylesterase Notum.
    Zhao Y; Jolly S; Benvegnu S; Jones EY; Fish PV
    Future Med Chem; 2021 Jun; 13(11):1001-1015. PubMed ID: 33882714
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structural characterization of melatonin as an inhibitor of the Wnt deacylase Notum.
    Zhao Y; Ren J; Hillier J; Jones M; Lu W; Jones EY
    J Pineal Res; 2020 Mar; 68(2):e12630. PubMed ID: 31876313
    [TBL] [Abstract][Full Text] [Related]  

  • 8. 4H-Thieno[3,2-c]chromene based inhibitors of Notum Pectinacetylesterase.
    Han Q; Pabba PK; Barbosa J; Mabon R; Healy JP; Gardyan MW; Terranova KM; Brommage R; Thompson AY; Schmidt JM; Wilson AG; Xu X; Tarver JE; Carson KG
    Bioorg Med Chem Lett; 2016 Feb; 26(4):1184-7. PubMed ID: 26821819
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structural Analysis and Development of Notum Fragment Screening Hits.
    Zhao Y; Mahy W; Willis NJ; Woodward HL; Steadman D; Bayle ED; Atkinson BN; Sipthorp J; Vecchia L; Ruza RR; Harlos K; Jeganathan F; Constantinou S; Costa A; Kjær S; Bictash M; Salinas PC; Whiting P; Vincent JP; Fish PV; Jones EY
    ACS Chem Neurosci; 2022 Jul; 13(13):2060-2077. PubMed ID: 35731924
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity.
    Mahy W; Patel M; Steadman D; Woodward HL; Atkinson BN; Svensson F; Willis NJ; Flint A; Papatheodorou D; Zhao Y; Vecchia L; Ruza RR; Hillier J; Frew S; Monaghan A; Costa A; Bictash M; Walter MW; Jones EY; Fish PV
    J Med Chem; 2020 Sep; 63(17):9464-9483. PubMed ID: 32787107
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen.
    Atkinson BN; Steadman D; Zhao Y; Sipthorp J; Vecchia L; Ruza RR; Jeganathan F; Lines G; Frew S; Monaghan A; Kjær S; Bictash M; Jones EY; Fish PV
    Medchemcomm; 2019 Aug; 10(8):1361-1369. PubMed ID: 31534655
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structural Insights into Notum Covalent Inhibition.
    Zhao Y; Svensson F; Steadman D; Frew S; Monaghan A; Bictash M; Moreira T; Chalk R; Lu W; Fish PV; Jones EY
    J Med Chem; 2021 Aug; 64(15):11354-11363. PubMed ID: 34292747
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity.
    Atkinson BN; Willis NJ; Zhao Y; Patel C; Frew S; Costelloe K; Magno L; Svensson F; Jones EY; Fish PV
    Eur J Med Chem; 2023 May; 251():115132. PubMed ID: 36934521
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Notum palmitoleoyl-protein carboxylesterase regulates Fas cell surface death receptor-mediated apoptosis via the Wnt signaling pathway in colon adenocarcinoma.
    Gong H; Niu Q; Zhou Y; Wang YX; Xu XF; Hou KZ
    Bioengineered; 2021 Dec; 12(1):5241-5252. PubMed ID: 34402722
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Stimulation of cortical bone formation with thienopyrimidine based inhibitors of Notum Pectinacetylesterase.
    Tarver JE; Pabba PK; Barbosa J; Han Q; Gardyan MW; Brommage R; Thompson AY; Schmidt JM; Wilson AGE; He W; Lombardo VK; Carson KG
    Bioorg Med Chem Lett; 2016 Mar; 26(6):1525-1528. PubMed ID: 26897593
    [TBL] [Abstract][Full Text] [Related]  

  • 16. [1,2,4]triazol-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: antagonists of the Wnt pathway that inhibit tankyrases 1 and 2 via novel adenosine pocket binding.
    Shultz MD; Kirby CA; Stams T; Chin DN; Blank J; Charlat O; Cheng H; Cheung A; Cong F; Feng Y; Fortin PD; Hood T; Tyagi V; Xu M; Zhang B; Shao W
    J Med Chem; 2012 Feb; 55(3):1127-36. PubMed ID: 22260203
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Notum deacylates Wnt proteins to suppress signalling activity.
    Kakugawa S; Langton PF; Zebisch M; Howell S; Chang TH; Liu Y; Feizi T; Bineva G; O'Reilly N; Snijders AP; Jones EY; Vincent JP
    Nature; 2015 Mar; 519(7542):187-192. PubMed ID: 25731175
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Novel 3-[4-alkoxy-3-(1H-tetrazol-1-yl) phenyl]-1,2,4-oxadiazol-5(4H)-ones as promising xanthine oxidase inhibitors: Design, synthesis and biological evaluation.
    Gao J; Zhang Z; Zhang B; Mao Q; Dai X; Zou Q; Lei Y; Feng Y; Wang S
    Bioorg Chem; 2020 Jan; 95():103564. PubMed ID: 31927335
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Caffeine inhibits Notum activity by binding at the catalytic pocket.
    Zhao Y; Ren J; Hillier J; Lu W; Jones EY
    Commun Biol; 2020 Oct; 3(1):555. PubMed ID: 33033363
    [TBL] [Abstract][Full Text] [Related]  

  • 20. NOTUM is a potential pharmacodynamic biomarker of Wnt pathway inhibition.
    Madan B; Ke Z; Lei ZD; Oliver FA; Oshima M; Lee MA; Rozen S; Virshup DM
    Oncotarget; 2016 Mar; 7(11):12386-92. PubMed ID: 26848981
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.