409 related articles for article (PubMed ID: 33168729)
1. Reversing the direction of drug transport mediated by the human multidrug transporter P-glycoprotein.
Sajid A; Lusvarghi S; Murakami M; Chufan EE; Abel B; Gottesman MM; Durell SR; Ambudkar SV
Proc Natl Acad Sci U S A; 2020 Nov; 117(47):29609-29617. PubMed ID: 33168729
[TBL] [Abstract][Full Text] [Related]
2. Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin, a major metabolite of curcumin.
Limtrakul P; Chearwae W; Shukla S; Phisalphong C; Ambudkar SV
Mol Cell Biochem; 2007 Feb; 296(1-2):85-95. PubMed ID: 16960658
[TBL] [Abstract][Full Text] [Related]
3. Evidence for the critical role of transmembrane helices 1 and 7 in substrate transport by human P-glycoprotein (ABCB1).
Sajid A; Lusvarghi S; Chufan EE; Ambudkar SV
PLoS One; 2018; 13(9):e0204693. PubMed ID: 30265721
[TBL] [Abstract][Full Text] [Related]
4. Global alteration of the drug-binding pocket of human P-glycoprotein (ABCB1) by substitution of fifteen conserved residues reveals a negative correlation between substrate size and transport efficiency.
Vahedi S; Chufan EE; Ambudkar SV
Biochem Pharmacol; 2017 Nov; 143():53-64. PubMed ID: 28728917
[TBL] [Abstract][Full Text] [Related]
5. Multiple transport-active binding sites are available for a single substrate on human P-glycoprotein (ABCB1).
Chufan EE; Kapoor K; Sim HM; Singh S; Talele TT; Durell SR; Ambudkar SV
PLoS One; 2013; 8(12):e82463. PubMed ID: 24349290
[TBL] [Abstract][Full Text] [Related]
6. Residues from Homologous Transmembrane Helices 4 and 10 Are Critical for P-Glycoprotein (ABCB1)-Mediated Drug Transport.
Rahman H; Ware MJ; Sajid A; Lusvarghi S; Durell SR; Ambudkar SV
Cancers (Basel); 2023 Jul; 15(13):. PubMed ID: 37444569
[TBL] [Abstract][Full Text] [Related]
7. Use of shape similarities for the classification of P-glycoprotein substrates and nonsubstrates.
Schwaha R; Ecker GF
Future Med Chem; 2011 Jul; 3(9):1117-28. PubMed ID: 21806376
[TBL] [Abstract][Full Text] [Related]
8. Dacomitinib antagonizes multidrug resistance (MDR) in cancer cells by inhibiting the efflux activity of ABCB1 and ABCG2 transporters.
Fan YF; Zhang W; Zeng L; Lei ZN; Cai CY; Gupta P; Yang DH; Cui Q; Qin ZD; Chen ZS; Trombetta LD
Cancer Lett; 2018 May; 421():186-198. PubMed ID: 29331420
[TBL] [Abstract][Full Text] [Related]
9. Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity.
Esser L; Zhou F; Pluchino KM; Shiloach J; Ma J; Tang WK; Gutierrez C; Zhang A; Shukla S; Madigan JP; Zhou T; Kwong PD; Ambudkar SV; Gottesman MM; Xia D
J Biol Chem; 2017 Jan; 292(2):446-461. PubMed ID: 27864369
[TBL] [Abstract][Full Text] [Related]
10. Multidrug ABC transporter Cdr1 of Candida albicans harbors specific and overlapping binding sites for human steroid hormones transport.
Baghel P; Rawal MK; Khan MF; Sen S; Siddiqui MH; Chaptal V; Falson P; Prasad R
Biochim Biophys Acta Biomembr; 2017 Oct; 1859(10):1778-1789. PubMed ID: 28559186
[TBL] [Abstract][Full Text] [Related]
11. A novel flavonoid from Fissistigma cupreonitens, 5‑hydroxy‑7,8‑dimethoxyflavanone, competitively inhibited the efflux function of human P-glycoprotein and reversed cancer multi-drug resistance.
Teng YN; Lin KI; Lin YC; Thang TD; Lan YH; Hung CC
Phytomedicine; 2021 May; 85():153528. PubMed ID: 33735724
[TBL] [Abstract][Full Text] [Related]
12. Sunitinib (Sutent, SU11248), a small-molecule receptor tyrosine kinase inhibitor, blocks function of the ATP-binding cassette (ABC) transporters P-glycoprotein (ABCB1) and ABCG2.
Shukla S; Robey RW; Bates SE; Ambudkar SV
Drug Metab Dispos; 2009 Feb; 37(2):359-65. PubMed ID: 18971320
[TBL] [Abstract][Full Text] [Related]
13. Drug-protein hydrogen bonds govern the inhibition of the ATP hydrolysis of the multidrug transporter P-glycoprotein.
Chufan EE; Kapoor K; Ambudkar SV
Biochem Pharmacol; 2016 Feb; 101():40-53. PubMed ID: 26686578
[TBL] [Abstract][Full Text] [Related]
14. Kuguacin J isolated from Momordica charantia leaves inhibits P-glycoprotein (ABCB1)-mediated multidrug resistance.
Pitchakarn P; Ohnuma S; Pintha K; Pompimon W; Ambudkar SV; Limtrakul P
J Nutr Biochem; 2012 Jan; 23(1):76-84. PubMed ID: 21414769
[TBL] [Abstract][Full Text] [Related]
15. Modulation by flavonoids of cell multidrug resistance mediated by P-glycoprotein and related ABC transporters.
Di Pietro A; Conseil G; Pérez-Victoria JM; Dayan G; Baubichon-Cortay H; Trompier D; Steinfels E; Jault JM; de Wet H; Maitrejean M; Comte G; Boumendjel A; Mariotte AM; Dumontet C; McIntosh DB; Goffeau A; Castanys S; Gamarro F; Barron D
Cell Mol Life Sci; 2002 Feb; 59(2):307-22. PubMed ID: 11915946
[TBL] [Abstract][Full Text] [Related]
16. Efflux ratio cannot assess P-glycoprotein-mediated attenuation of absorptive transport: asymmetric effect of P-glycoprotein on absorptive and secretory transport across Caco-2 cell monolayers.
Troutman MD; Thakker DR
Pharm Res; 2003 Aug; 20(8):1200-9. PubMed ID: 12948018
[TBL] [Abstract][Full Text] [Related]
17. Molecular basis of the polyspecificity of P-glycoprotein (ABCB1): recent biochemical and structural studies.
Chufan EE; Sim HM; Ambudkar SV
Adv Cancer Res; 2015; 125():71-96. PubMed ID: 25640267
[TBL] [Abstract][Full Text] [Related]
18. Tenulin and isotenulin inhibit P-glycoprotein function and overcome multidrug resistance in cancer cells.
Chang YT; Wang CCN; Wang JY; Lee TE; Cheng YY; Morris-Natschke SL; Lee KH; Hung CC
Phytomedicine; 2019 Feb; 53():252-262. PubMed ID: 30668405
[TBL] [Abstract][Full Text] [Related]
19. Identification of proline residues in or near the transmembrane helices of the human breast cancer resistance protein (BCRP/ABCG2) that are important for transport activity and substrate specificity.
Ni Z; Bikadi Z; Shuster DL; Zhao C; Rosenberg MF; Mao Q
Biochemistry; 2011 Sep; 50(37):8057-66. PubMed ID: 21854076
[TBL] [Abstract][Full Text] [Related]
20. β-carotene reverses multidrug resistant cancer cells by selectively modulating human P-glycoprotein function.
Teng YN; Sheu MJ; Hsieh YW; Wang RY; Chiang YC; Hung CC
Phytomedicine; 2016 Mar; 23(3):316-23. PubMed ID: 26969385
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
