255 related articles for article (PubMed ID: 33196949)
1. Albumin-Mediated Uptake Improves Human Clearance Prediction for Hepatic Uptake Transporter Substrates Aiding a Mechanistic In Vitro-In Vivo Extrapolation (IVIVE) Strategy in Discovery Research.
Li N; Badrinarayanan A; Ishida K; Li X; Roberts J; Wang S; Hayashi M; Gupta A
AAPS J; 2020 Nov; 23(1):1. PubMed ID: 33196949
[TBL] [Abstract][Full Text] [Related]
2. Comparison of In Vitro to In Vivo Extrapolation Approaches for Predicting Transporter-Mediated Hepatic Uptake Clearance Using Suspended Rat Hepatocytes.
Li N; Badrinarayanan A; Li X; Roberts J; Hayashi M; Virk M; Gupta A
Drug Metab Dispos; 2020 Oct; 48(10):861-872. PubMed ID: 32759366
[TBL] [Abstract][Full Text] [Related]
3. Comparison of the Predictability of Human Hepatic Clearance for Organic Anion Transporting Polypeptide Substrate Drugs Between Different In Vitro-In Vivo Extrapolation Approaches.
Izumi S; Nozaki Y; Komori T; Takenaka O; Maeda K; Kusuhara H; Sugiyama Y
J Pharm Sci; 2017 Sep; 106(9):2678-2687. PubMed ID: 28238896
[TBL] [Abstract][Full Text] [Related]
4. Extrapolation of In Vivo Hepatic Clearance from In Vitro Uptake Clearance by Suspended Human Hepatocytes for Anionic Drugs with High Binding to Human Albumin: Improvement of In Vitro-to-In Vivo Extrapolation by Considering the "Albumin-Mediated" Hepatic Uptake Mechanism on the Basis of the "Facilitated-Dissociation Model".
Kim SJ; Lee KR; Miyauchi S; Sugiyama Y
Drug Metab Dispos; 2019 Feb; 47(2):94-103. PubMed ID: 30504137
[TBL] [Abstract][Full Text] [Related]
5. Extrapolation of the Hepatic Clearance of Drugs in the Absence of Albumin In Vitro to That in the Presence of Albumin In Vivo: Comparative Assessement of 2 Extrapolation Models Based on the Albumin-Mediated Hepatic Uptake Theory and Limitations and Mechanistic Insights.
Poulin P; Haddad S
J Pharm Sci; 2018 Jul; 107(7):1791-1797. PubMed ID: 29567347
[TBL] [Abstract][Full Text] [Related]
6. Hepatic Organic Anion Transporting Polypeptide-Mediated Clearance in the Beagle Dog: Assessing In Vitro-In Vivo Relationships and Applying Cross-Species Empirical Scaling Factors to Improve Prediction of Human Clearance.
Matsunaga N; Ufuk A; Morse BL; Bedwell DW; Bao J; Mohutsky MA; Hillgren KM; Hall SD; Houston JB; Galetin A
Drug Metab Dispos; 2019 Mar; 47(3):215-226. PubMed ID: 30593544
[TBL] [Abstract][Full Text] [Related]
7. Effect of Human Plasma on Hepatic Uptake of Organic Anion-Transporting Polypeptide 1B Substrates: Studies Using Transfected Cells and Primary Human Hepatocytes.
Bi YA; Ryu S; Tess DA; Rodrigues AD; Varma MVS
Drug Metab Dispos; 2021 Jan; 49(1):72-83. PubMed ID: 33139461
[TBL] [Abstract][Full Text] [Related]
8. In Vitro Hepatic Uptake in Human and Monkey Hepatocytes in the Presence and Absence of Serum Protein and Its In Vitro to In Vivo Extrapolation.
Liang X; Park Y; DeForest N; Hao J; Zhao X; Niu C; Wang K; Smith B; Lai Y
Drug Metab Dispos; 2020 Dec; 48(12):1283-1292. PubMed ID: 33037043
[TBL] [Abstract][Full Text] [Related]
9. Prediction of total hepatic clearance by combining metabolism, transport, and permeability data in the in vitro-in vivo extrapolation methods: emphasis on an apparent fraction unbound in liver for drugs.
Poulin P
J Pharm Sci; 2013 Jul; 102(7):2085-95. PubMed ID: 23613473
[TBL] [Abstract][Full Text] [Related]
10. Strategies to improve the prediction accuracy of hepatic intrinsic clearance of three antidiabetic drugs: Application of the extended clearance concept and consideration of the effect of albumin on CYP2C metabolism and OATP1B-mediated hepatic uptake.
Fujino R; Hashizume K; Aoyama S; Maeda K; Ito K; Toshimoto K; Lee W; Ninomiya SI; Sugiyama Y
Eur J Pharm Sci; 2018 Dec; 125():181-192. PubMed ID: 30287410
[TBL] [Abstract][Full Text] [Related]
11. The Phenomenon of Albumin-Mediated Hepatic Uptake of Organic Anion Transport Polypeptide Substrates: Prediction of the In Vivo Uptake Clearance from the In Vitro Uptake by Isolated Hepatocytes Using a Facilitated-Dissociation Model.
Miyauchi S; Masuda M; Kim SJ; Tanaka Y; Lee KR; Iwakado S; Nemoto M; Sasaki S; Shimono K; Tanaka Y; Sugiyama Y
Drug Metab Dispos; 2018 Mar; 46(3):259-267. PubMed ID: 29298773
[TBL] [Abstract][Full Text] [Related]
12. Predicting Human Clearance of Organic Anion Transporting Polypeptide Substrates Using Cynomolgus Monkey: In Vitro-In Vivo Scaling of Hepatic Uptake Clearance.
De Bruyn T; Ufuk A; Cantrill C; Kosa RE; Bi YA; Niosi M; Modi S; Rodrigues AD; Tremaine LM; Varma MVS; Galetin A; Houston JB
Drug Metab Dispos; 2018 Jul; 46(7):989-1000. PubMed ID: 29720472
[TBL] [Abstract][Full Text] [Related]
13. Evaluation of the Utility of PXB Chimeric Mice for Predicting Human Liver Partitioning of Hepatic Organic Anion-Transporting Polypeptide Transporter Substrates.
Feng B; Pemberton R; Dworakowski W; Ye Z; Zetterberg C; Wang G; Morikawa Y; Kumar S
Drug Metab Dispos; 2021 Mar; 49(3):254-264. PubMed ID: 33376106
[TBL] [Abstract][Full Text] [Related]
14. Toward a new paradigm for the efficient in vitro-in vivo extrapolation of metabolic clearance in humans from hepatocyte data.
Poulin P; Haddad S
J Pharm Sci; 2013 Sep; 102(9):3239-51. PubMed ID: 23494893
[TBL] [Abstract][Full Text] [Related]
15. Physiologically Based Pharmacokinetic Modeling of Transporter-Mediated Hepatic Clearance and Liver Partitioning of OATP and OCT Substrates in Cynomolgus Monkeys.
Morse BL; MacGuire JG; Marino AM; Zhao Y; Fox M; Zhang Y; Shen H; Griffith Humphreys W; Marathe P; Lai Y
AAPS J; 2017 Nov; 19(6):1878-1889. PubMed ID: 29019117
[TBL] [Abstract][Full Text] [Related]
16. Prediction of Transporter-Mediated Rosuvastatin Hepatic Uptake Clearance and Drug Interaction in Humans Using Proteomics-Informed REF Approach.
Kumar V; Yin M; Ishida K; Salphati L; Hop CECA; Rowbottom C; Xiao G; Lai Y; Mathias A; Chu X; Humphreys WG; Liao M; Nerada Z; Szilvásy N; Heyward S; Unadkat JD
Drug Metab Dispos; 2021 Feb; 49(2):159-168. PubMed ID: 33051248
[TBL] [Abstract][Full Text] [Related]
17. Impact of Plasma Protein Binding in Drug Clearance Prediction: A Data Base Analysis of Published Studies and Implications for In Vitro-In Vivo Extrapolation.
Francis LJ; Houston JB; Hallifax D
Drug Metab Dispos; 2021 Mar; 49(3):188-201. PubMed ID: 33355201
[TBL] [Abstract][Full Text] [Related]
18. Novel Method to Predict In Vivo Liver-to-Plasma K
Riccardi K; Lin J; Li Z; Niosi M; Ryu S; Hua W; Atkinson K; Kosa RE; Litchfield J; Di L
Drug Metab Dispos; 2017 May; 45(5):576-580. PubMed ID: 28258068
[TBL] [Abstract][Full Text] [Related]
19. Improving Prediction of Metabolic Clearance Using Quantitative Extrapolation of Results Obtained From Human Hepatic Micropatterned Cocultures Model and by Considering the Impact of Albumin Binding.
Da-Silva F; Boulenc X; Vermet H; Compigne P; Gerbal-Chaloin S; Daujat-Chavanieu M; Klieber S; Poulin P
J Pharm Sci; 2018 Jul; 107(7):1957-1972. PubMed ID: 29524447
[TBL] [Abstract][Full Text] [Related]
20. Uridine 5'-Diphospho-glucuronosyltransferase 1A3 (UGT1A3) Prediction of Hepatic Clearance of Organic Anion Transporting Polypeptide 1B3 (OATP1B3) Substrate Telmisartan by Glucuronidation Using In Vitro-In Vivo Extrapolation (IVIVE).
Gabor-Worwa E; Kowal-Chwast A; Gaud N; Gogola D; Littlewood P; Smoluch M; Brzózka K; Kus K
Eur J Drug Metab Pharmacokinet; 2024 May; 49(3):393-403. PubMed ID: 38642299
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]