BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

537 related articles for article (PubMed ID: 33197925)

  • 1. CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells.
    Surka C; Jin L; Mbong N; Lu CC; Jang IS; Rychak E; Mendy D; Clayton T; Tindall E; Hsu C; Fontanillo C; Tran E; Contreras A; Ng SWK; Matyskiela M; Wang K; Chamberlain P; Cathers B; Carmichael J; Hansen J; Wang JCY; Minden MD; Fan J; Pierce DW; Pourdehnad M; Rolfe M; Lopez-Girona A; Dick JE; Lu G
    Blood; 2021 Feb; 137(5):661-677. PubMed ID: 33197925
    [TBL] [Abstract][Full Text] [Related]  

  • 2. CC-90009: A Cereblon E3 Ligase Modulating Drug That Promotes Selective Degradation of GSPT1 for the Treatment of Acute Myeloid Leukemia.
    Hansen JD; Correa M; Alexander M; Nagy M; Huang D; Sapienza J; Lu G; LeBrun LA; Cathers BE; Zhang W; Tang Y; Ammirante M; Narla RK; Piccotti JR; Pourdehnad M; Lopez-Girona A
    J Med Chem; 2021 Feb; 64(4):1835-1843. PubMed ID: 33591756
    [TBL] [Abstract][Full Text] [Related]  

  • 3. A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase.
    Matyskiela ME; Lu G; Ito T; Pagarigan B; Lu CC; Miller K; Fang W; Wang NY; Nguyen D; Houston J; Carmel G; Tran T; Riley M; Nosaka L; Lander GC; Gaidarova S; Xu S; Ruchelman AL; Handa H; Carmichael J; Daniel TO; Cathers BE; Lopez-Girona A; Chamberlain PP
    Nature; 2016 Jul; 535(7611):252-7. PubMed ID: 27338790
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Cereblon Promotes the Ubiquitination and Proteasomal Degradation of Interleukin Enhancer-Binding Factor 2.
    Lian Q; Gao Y; Li Q; He X; Jiang X; Pu Z; Xu G
    Protein J; 2020 Oct; 39(5):411-421. PubMed ID: 33009960
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The novel cereblon modulator CC-885 inhibits mitophagy via selective degradation of BNIP3L.
    Hao BB; Li XJ; Jia XL; Wang YX; Zhai LH; Li DZ; Liu J; Zhang D; Chen YL; Xu YH; Lee SK; Xu GF; Chen XH; Dang YJ; Liu B; Tan MJ
    Acta Pharmacol Sin; 2020 Sep; 41(9):1246-1254. PubMed ID: 32210356
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Exploiting ubiquitin ligase cereblon as a target for small-molecule compounds in medicine and chemical biology.
    Ito T; Yamaguchi Y; Handa H
    Cell Chem Biol; 2021 Jul; 28(7):987-999. PubMed ID: 34033753
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Cereblon modulator CC-885 induces CRBN-dependent ubiquitination and degradation of CDK4 in multiple myeloma.
    Zhao M; Hu M; Chen Y; Liu H; Chen Y; Liu B; Fang B
    Biochem Biophys Res Commun; 2021 Apr; 549():150-156. PubMed ID: 33676183
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Selective Degradation of GSPT1 by Cereblon Modulators Identified via a Focused Combinatorial Library.
    Powell CE; Du G; Che J; He Z; Donovan KA; Yue H; Wang ES; Nowak RP; Zhang T; Fischer ES; Gray NS
    ACS Chem Biol; 2020 Oct; 15(10):2722-2730. PubMed ID: 32865967
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Deciphering the mechanisms of CC-122 resistance in DLBCL via a genome-wide CRISPR screen.
    Mo Z; Wood S; Namiranian S; Mizukoshi R; Weng S; Jang IS; Fontanillo C; Baughman JM; Silva-Torres A; Slade M; Khater M; Wang K; Rolfe M; Lu G
    Blood Adv; 2021 Apr; 5(7):2027-2039. PubMed ID: 33847741
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Protein Degradation via CRL4
    Hansen JD; Condroski K; Correa M; Muller G; Man HW; Ruchelman A; Zhang W; Vocanson F; Crea T; Liu W; Lu G; Baculi F; LeBrun L; Mahmoudi A; Carmel G; Hickman M; Lu CC
    J Med Chem; 2018 Jan; 61(2):492-503. PubMed ID: 28358507
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon.
    Akuffo AA; Alontaga AY; Metcalf R; Beatty MS; Becker A; McDaniel JM; Hesterberg RS; Goodheart WE; Gunawan S; Ayaz M; Yang Y; Karim MR; Orobello ME; Daniel K; Guida W; Yoder JA; Rajadhyaksha AM; Schönbrunn E; Lawrence HR; Lawrence NJ; Epling-Burnette PK
    J Biol Chem; 2018 Apr; 293(16):6187-6200. PubMed ID: 29449372
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Degradation of GSPT1 causes TP53-independent cell death in leukemia while sparing normal hematopoietic stem cells.
    Sellar RS; Sperling AS; Słabicki M; Gasser JA; McConkey ME; Donovan KA; Mageed N; Adams DN; Zou C; Miller PG; Dutta RK; Boettcher S; Lin AE; Sandoval B; Quevedo Barrios VA; Kovalcik V; Koeppel J; Henderson EK; Fink EC; Yang L; Chan A; Pokharel SP; Bergstrom EJ; Burt R; Udeshi ND; Carr SA; Fischer ES; Chen CW; Ebert BL
    J Clin Invest; 2022 Aug; 132(16):. PubMed ID: 35763353
    [TBL] [Abstract][Full Text] [Related]  

  • 13. CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL.
    Hagner PR; Man HW; Fontanillo C; Wang M; Couto S; Breider M; Bjorklund C; Havens CG; Lu G; Rychak E; Raymon H; Narla RK; Barnes L; Khambatta G; Chiu H; Kosek J; Kang J; Amantangelo MD; Waldman M; Lopez-Girona A; Cai T; Pourdehnad M; Trotter M; Daniel TO; Schafer PH; Klippel A; Thakurta A; Chopra R; Gandhi AK
    Blood; 2015 Aug; 126(6):779-89. PubMed ID: 26002965
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The orally bioavailable GSPT1/2 degrader SJ6986 exhibits in vivo efficacy in acute lymphoblastic leukemia.
    Chang Y; Keramatnia F; Ghate PS; Nishiguchi G; Gao Q; Iacobucci I; Yang L; Chepyala D; Mishra A; High AA; Goto H; Akahane K; Peng J; Yang JJ; Fischer M; Rankovic Z; Mullighan CG
    Blood; 2023 Aug; 142(7):629-642. PubMed ID: 37172201
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Proximity interactome analysis of Lassa polymerase reveals eRF3a/GSPT1 as a druggable target for host-directed antivirals.
    Fang J; Pietzsch C; Witwit H; Tsaprailis G; Crynen G; Cho KF; Ting AY; Bukreyev A; Saphire EO; de la Torre JC
    Proc Natl Acad Sci U S A; 2022 Jul; 119(30):e2201208119. PubMed ID: 35858434
    [TBL] [Abstract][Full Text] [Related]  

  • 16. E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones.
    Ishida T; Ciulli A
    SLAS Discov; 2021 Apr; 26(4):484-502. PubMed ID: 33143537
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Identification of Potent, Selective, and Orally Bioavailable Small-Molecule GSPT1/2 Degraders from a Focused Library of Cereblon Modulators.
    Nishiguchi G; Keramatnia F; Min J; Chang Y; Jonchere B; Das S; Actis M; Price J; Chepyala D; Young B; McGowan K; Slavish PJ; Mayasundari A; Jarusiewicz JA; Yang L; Li Y; Fu X; Garrett SH; Papizan JB; Kodali K; Peng J; Pruett Miller SM; Roussel MF; Mullighan C; Fischer M; Rankovic Z
    J Med Chem; 2021 Jun; 64(11):7296-7311. PubMed ID: 34042448
    [TBL] [Abstract][Full Text] [Related]  

  • 18. UBE2G1 governs the destruction of cereblon neomorphic substrates.
    Lu G; Weng S; Matyskiela M; Zheng X; Fang W; Wood S; Surka C; Mizukoshi R; Lu CC; Mendy D; Jang IS; Wang K; Marella M; Couto S; Cathers B; Carmichael J; Chamberlain P; Rolfe M
    Elife; 2018 Sep; 7():. PubMed ID: 30234487
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Cereblon Modulators Target ZBTB16 and Its Oncogenic Fusion Partners for Degradation via Distinct Structural Degrons.
    Matyskiela ME; Zhu J; Baughman JM; Clayton T; Slade M; Wong HK; Danga K; Zheng X; Labow M; LeBrun L; Lu G; Chamberlain PP; Thompson JW
    ACS Chem Biol; 2020 Dec; 15(12):3149-3158. PubMed ID: 33206504
    [TBL] [Abstract][Full Text] [Related]  

  • 20. USP15 antagonizes CRL4
    Nguyen TV
    Proc Natl Acad Sci U S A; 2021 Oct; 118(40):. PubMed ID: 34583995
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 27.