BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

184 related articles for article (PubMed ID: 33199508)

  • 1. Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers.
    Newman JA; Gavard AE; Lieb S; Ravichandran MC; Hauer K; Werni P; Geist L; Böttcher J; Engen JR; Rumpel K; Samwer M; Petronczki M; Gileadi O
    Life Sci Alliance; 2021 Jan; 4(1):. PubMed ID: 33199508
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells.
    Lieb S; Blaha-Ostermann S; Kamper E; Rippka J; Schwarz C; Ehrenhöfer-Wölfer K; Schlattl A; Wernitznig A; Lipp JJ; Nagasaka K; van der Lelij P; Bader G; Koi M; Goel A; Neumüller RA; Peters JM; Kraut N; Pearson MA; Petronczki M; Wöhrle S
    Elife; 2019 Mar; 8():. PubMed ID: 30910006
    [TBL] [Abstract][Full Text] [Related]  

  • 3. WRN Is a Promising Synthetic Lethal Target for Cancers with Microsatellite Instability (MSI).
    Chan EM; Foster KJ; Bass AJ
    Cancer Treat Res; 2023; 186():313-328. PubMed ID: 37978143
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Targeting ATP-binding site of WRN Helicase: Identification of novel inhibitors through pocket analysis and Molecular Dynamics-Enhanced virtual screening.
    Yuan H; Liu RD; Gao ZY; Zhong LT; Zhou YC; Tan JH; Huang ZS; Li Z; Chen SB
    Bioorg Med Chem Lett; 2024 May; 104():129711. PubMed ID: 38521175
    [TBL] [Abstract][Full Text] [Related]  

  • 5. WRN helicase is a synthetic lethal target in microsatellite unstable cancers.
    Chan EM; Shibue T; McFarland JM; Gaeta B; Ghandi M; Dumont N; Gonzalez A; McPartlan JS; Li T; Zhang Y; Bin Liu J; Lazaro JB; Gu P; Piett CG; Apffel A; Ali SO; Deasy R; Keskula P; Ng RWS; Roberts EA; Reznichenko E; Leung L; Alimova M; Schenone M; Islam M; Maruvka YE; Liu Y; Roper J; Raghavan S; Giannakis M; Tseng YY; Nagel ZD; D'Andrea A; Root DE; Boehm JS; Getz G; Chang S; Golub TR; Tsherniak A; Vazquez F; Bass AJ
    Nature; 2019 Apr; 568(7753):551-556. PubMed ID: 30971823
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers.
    Ferretti S; Hamon J; de Kanter R; Scheufler C; Andraos-Rey R; Barbe S; Bechter E; Blank J; Bordas V; Dammassa E; Decker A; Di Nanni N; Dourdoigne M; Gavioli E; Hattenberger M; Heuser A; Hemmerlin C; Hinrichs J; Kerr G; Laborde L; Jaco I; Núñez EJ; Martus HJ; Quadt C; Reschke M; Romanet V; Schaeffer F; Schoepfer J; Schrapp M; Strang R; Voshol H; Wartmann M; Welly S; Zécri F; Hofmann F; Möbitz H; Cortés-Cros M
    Nature; 2024 May; 629(8011):443-449. PubMed ID: 38658754
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase.
    Baltgalvis KA; Lamb KN; Symons KT; Wu CC; Hoffman MA; Snead AN; Song X; Glaza T; Kikuchi S; Green JC; Rogness DC; Lam B; Rodriguez-Aguirre ME; Woody DR; Eissler CL; Rodiles S; Negron SM; Bernard SM; Tran E; Pollock J; Tabatabaei A; Contreras V; Williams HN; Pastuszka MK; Sigler JJ; Pettazzoni P; Rudolph MG; Classen M; Brugger D; Claiborne C; Plancher JM; Cuartas I; Seoane J; Burgess LE; Abraham RT; Weinstein DS; Simon GM; Patricelli MP; Kinsella TM
    Nature; 2024 May; 629(8011):435-442. PubMed ID: 38658751
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Crystal structure of the HRDC domain of human Werner syndrome protein, WRN.
    Kitano K; Yoshihara N; Hakoshima T
    J Biol Chem; 2007 Jan; 282(4):2717-28. PubMed ID: 17148451
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Werner Helicase Is a Synthetic-Lethal Vulnerability in Mismatch Repair-Deficient Colorectal Cancer Refractory to Targeted Therapies, Chemotherapy, and Immunotherapy.
    Picco G; Cattaneo CM; van Vliet EJ; Crisafulli G; Rospo G; Consonni S; Vieira SF; Rodríguez IS; Cancelliere C; Banerjee R; Schipper LJ; Oddo D; Dijkstra KK; Cinatl J; Michaelis M; Yang F; Di Nicolantonio F; Sartore-Bianchi A; Siena S; Arena S; Voest EE; Bardelli A; Garnett MJ;
    Cancer Discov; 2021 Aug; 11(8):1923-1937. PubMed ID: 33837064
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Residues in the RecQ C-terminal Domain of the Human Werner Syndrome Helicase Are Involved in Unwinding G-quadruplex DNA.
    Ketkar A; Voehler M; Mukiza T; Eoff RL
    J Biol Chem; 2017 Feb; 292(8):3154-3163. PubMed ID: 28069813
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthetical lethality of Werner helicase and mismatch repair deficiency is mediated by p53 and PUMA in colon cancer.
    Hao S; Tong J; Jha A; Risnik D; Lizardo D; Lu X; Goel A; Opresko PL; Yu J; Zhang L
    Proc Natl Acad Sci U S A; 2022 Dec; 119(51):e2211775119. PubMed ID: 36508676
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The enzymatic activities of the Werner syndrome protein are disabled by the amino acid polymorphism R834C.
    Kamath-Loeb AS; Welcsh P; Waite M; Adman ET; Loeb LA
    J Biol Chem; 2004 Dec; 279(53):55499-505. PubMed ID: 15489508
    [TBL] [Abstract][Full Text] [Related]  

  • 13. WRN helicase and mismatch repair complexes independently and synergistically disrupt cruciform DNA structures.
    Mengoli V; Ceppi I; Sanchez A; Cannavo E; Halder S; Scaglione S; Gaillard PH; McHugh PJ; Riesen N; Pettazzoni P; Cejka P
    EMBO J; 2023 Feb; 42(3):e111998. PubMed ID: 36541070
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The WRN helicase: resolving a new target in microsatellite unstable cancers.
    van Wietmarschen N; Nathan WJ; Nussenzweig A
    Curr Opin Genet Dev; 2021 Dec; 71():34-38. PubMed ID: 34284257
    [TBL] [Abstract][Full Text] [Related]  

  • 15. WRN suppresses p53/PUMA-induced apoptosis in colorectal cancer with microsatellite instability/mismatch repair deficiency.
    Sobol RW
    Proc Natl Acad Sci U S A; 2023 Jan; 120(2):e2219963120. PubMed ID: 36598947
    [No Abstract]   [Full Text] [Related]  

  • 16. Discovery of thiophen-2-ylmethylene bis-dimedone derivatives as novel WRN inhibitors for treating cancers with microsatellite instability.
    Yang H; Kang M; Jang S; Baek SY; Kim J; Kim GU; Kim D; Ha J; Kim JS; Jung C; Kim NJ; Cho SY; Shin WH; Lee J; Ko J; Lee A; Keum G; Lee S; Kang T
    Bioorg Med Chem; 2024 Feb; 100():117588. PubMed ID: 38295487
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Biochemical and kinetic characterization of the DNA helicase and exonuclease activities of werner syndrome protein.
    Choudhary S; Sommers JA; Brosh RM
    J Biol Chem; 2004 Aug; 279(33):34603-13. PubMed ID: 15187093
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The Werner Syndrome Helicase Coordinates Sequential Strand Displacement and FEN1-Mediated Flap Cleavage during Polymerase δ Elongation.
    Li B; Reddy S; Comai L
    Mol Cell Biol; 2017 Feb; 37(3):. PubMed ID: 27849570
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Werner Syndrome Helicase Is Required for the Survival of Cancer Cells with Microsatellite Instability.
    Kategaya L; Perumal SK; Hager JH; Belmont LD
    iScience; 2019 Mar; 13():488-497. PubMed ID: 30898619
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Regulation of WRN helicase activity in human base excision repair.
    Ahn B; Harrigan JA; Indig FE; Wilson DM; Bohr VA
    J Biol Chem; 2004 Dec; 279(51):53465-74. PubMed ID: 15385537
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.