BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

208 related articles for article (PubMed ID: 33228353)

  • 1. L-Type Amino Acid Transporter 1 Enables the Efficient Brain Delivery of Small-Sized Prodrug across the Blood-Brain Barrier and into Human and Mouse Brain Parenchymal Cells.
    Montaser AB; Järvinen J; Löffler S; Huttunen J; Auriola S; Lehtonen M; Jalkanen A; Huttunen KM
    ACS Chem Neurosci; 2020 Dec; 11(24):4301-4315. PubMed ID: 33228353
    [TBL] [Abstract][Full Text] [Related]  

  • 2. L-type amino acid transporter 1 utilizing prodrugs of ferulic acid revealed structural features supporting the design of prodrugs for brain delivery.
    Puris E; Gynther M; Huttunen J; Auriola S; Huttunen KM
    Eur J Pharm Sci; 2019 Mar; 129():99-109. PubMed ID: 30625368
    [TBL] [Abstract][Full Text] [Related]  

  • 3. L-type amino acid transporter 1 utilizing prodrugs: How to achieve effective brain delivery and low systemic exposure of drugs.
    Puris E; Gynther M; Huttunen J; Petsalo A; Huttunen KM
    J Control Release; 2017 Sep; 261():93-104. PubMed ID: 28662899
    [TBL] [Abstract][Full Text] [Related]  

  • 4. L-Type Amino Acid Transporter 1 (LAT1/Lat1)-Utilizing Prodrugs Can Improve the Delivery of Drugs into Neurons, Astrocytes and Microglia.
    Huttunen J; Peltokangas S; Gynther M; Natunen T; Hiltunen M; Auriola S; Ruponen M; Vellonen KS; Huttunen KM
    Sci Rep; 2019 Sep; 9(1):12860. PubMed ID: 31492955
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Mechanistic Study on the Use of the l-Type Amino Acid Transporter 1 for Brain Intracellular Delivery of Ketoprofen via Prodrug: A Novel Approach Supporting the Development of Prodrugs for Intracellular Targets.
    Puris E; Gynther M; de Lange ECM; Auriola S; Hammarlund-Udenaes M; Huttunen KM; Loryan I
    Mol Pharm; 2019 Jul; 16(7):3261-3274. PubMed ID: 31180686
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Large amino acid transporter 1 (LAT1) prodrugs of valproic acid: new prodrug design ideas for central nervous system delivery.
    Peura L; Malmioja K; Laine K; Leppänen J; Gynther M; Isotalo A; Rautio J
    Mol Pharm; 2011 Oct; 8(5):1857-66. PubMed ID: 21770378
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Improved l-Type amino acid transporter 1 (LAT1)-mediated delivery of anti-inflammatory drugs into astrocytes and microglia with reduced prostaglandin production.
    Tampio J; Löffler S; Guillon M; Hugele A; Huttunen J; Huttunen KM
    Int J Pharm; 2021 May; 601():120565. PubMed ID: 33812973
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Design, synthesis and brain uptake of LAT1-targeted amino acid prodrugs of dopamine.
    Peura L; Malmioja K; Huttunen K; Leppänen J; Hämäläinen M; Forsberg MM; Gynther M; Rautio J; Laine K
    Pharm Res; 2013 Oct; 30(10):2523-37. PubMed ID: 24137801
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Quantitative insight into the design of compounds recognized by the L-type amino acid transporter 1 (LAT1).
    Ylikangas H; Malmioja K; Peura L; Gynther M; Nwachukwu EO; Leppänen J; Laine K; Rautio J; Lahtela-Kakkonen M; Huttunen KM; Poso A
    ChemMedChem; 2014 Dec; 9(12):2699-707. PubMed ID: 25205473
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Large neutral amino acid transporter enables brain drug delivery via prodrugs.
    Gynther M; Laine K; Ropponen J; Leppänen J; Mannila A; Nevalainen T; Savolainen J; Järvinen T; Rautio J
    J Med Chem; 2008 Feb; 51(4):932-6. PubMed ID: 18217702
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Brain uptake of ketoprofen-lysine prodrug in rats.
    Gynther M; Jalkanen A; Lehtonen M; Forsberg M; Laine K; Ropponen J; Leppänen J; Knuuti J; Rautio J
    Int J Pharm; 2010 Oct; 399(1-2):121-8. PubMed ID: 20727958
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Hemocompatible L-Type amino acid transporter 1 (LAT1)-Utilizing prodrugs of perforin inhibitors can accumulate into the pancreas and alleviate inflammation-induced apoptosis.
    Tampio J; Markowicz-Piasecka M; Huttunen KM
    Chem Biol Interact; 2021 Aug; 345():109560. PubMed ID: 34153225
    [TBL] [Abstract][Full Text] [Related]  

  • 13. L-Type amino acid transporter 1 (LAT1)-utilizing prodrugs are carrier-selective despite having low affinity for organic anion transporting polypeptides (OATPs).
    Huttunen J; Gynther M; Vellonen KS; Huttunen KM
    Int J Pharm; 2019 Nov; 571():118714. PubMed ID: 31610281
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Amino Acid Promoieties Alter Valproic Acid Pharmacokinetics and Enable Extended Brain Exposure.
    Gynther M; Peura L; Vernerová M; Leppänen J; Kärkkäinen J; Lehtonen M; Rautio J; Huttunen KM
    Neurochem Res; 2016 Oct; 41(10):2797-2809. PubMed ID: 27412117
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Amino acid ester prodrugs conjugated to the α-carboxylic acid group do not display affinity for the L-type amino acid transporter 1 (LAT1).
    Rautio J; Kärkkäinen J; Huttunen KM; Gynther M
    Eur J Pharm Sci; 2015 Jan; 66():36-40. PubMed ID: 25305508
    [TBL] [Abstract][Full Text] [Related]  

  • 16. L-Type amino acid transporter 1 as a target for drug delivery.
    Puris E; Gynther M; Auriola S; Huttunen KM
    Pharm Res; 2020 May; 37(5):88. PubMed ID: 32377929
    [TBL] [Abstract][Full Text] [Related]  

  • 17. L-Type amino acid transporter 1 (lat1)-mediated targeted delivery of perforin inhibitors.
    Huttunen KM; Huttunen J; Aufderhaar I; Gynther M; Denny WA; Spicer JA
    Int J Pharm; 2016 Feb; 498(1-2):205-16. PubMed ID: 26705152
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Targeting of Perforin Inhibitor into the Brain Parenchyma Via a Prodrug Approach Can Decrease Oxidative Stress and Neuroinflammation and Improve Cell Survival.
    Tampio J; Huttunen J; Montaser A; Huttunen KM
    Mol Neurobiol; 2020 Nov; 57(11):4563-4577. PubMed ID: 32754897
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Transport of Pregabalin Via L-Type Amino Acid Transporter 1 (SLC7A5) in Human Brain Capillary Endothelial Cell Line.
    Takahashi Y; Nishimura T; Higuchi K; Noguchi S; Tega Y; Kurosawa T; Deguchi Y; Tomi M
    Pharm Res; 2018 Oct; 35(12):246. PubMed ID: 30374619
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The Effects of Prodrug Size and a Carbonyl Linker on l-Type Amino Acid Transporter 1-Targeted Cellular and Brain Uptake.
    Venteicher B; Merklin K; Ngo HX; Chien HC; Hutchinson K; Campbell J; Way H; Griffith J; Alvarado C; Chandra S; Hill E; Schlessinger A; Thomas AA
    ChemMedChem; 2021 Mar; 16(5):869-880. PubMed ID: 33230949
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.