These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

70 related articles for article (PubMed ID: 3325050)

  • 1. Kinetic isotope effects and 'metabolic switching' in cytochrome P450-catalyzed reactions.
    Miwa GT; Lu AY
    Bioessays; 1987 Nov; 7(5):215-9. PubMed ID: 3325050
    [No Abstract]   [Full Text] [Related]  

  • 2. Kinetic deuterium isotope effects for 7-alkoxycoumarin O-dealkylation reactions catalyzed by human cytochromes P450 and in liver microsomes. Rate-limiting C-H bond breaking in cytochrome P450 1A2 substrate oxidation.
    Kim KH; Isin EM; Yun CH; Kim DH; Guengerich FP
    FEBS J; 2006 May; 273(10):2223-31. PubMed ID: 16649998
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The use of deuterium isotope effects to probe the active site properties, mechanism of cytochrome P450-catalyzed reactions, and mechanisms of metabolically dependent toxicity.
    Nelson SD; Trager WF
    Drug Metab Dispos; 2003 Dec; 31(12):1481-98. PubMed ID: 14625345
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Kinetic isotope effects implicate two electrophilic oxidants in cytochrome p450-catalyzed hydroxylations.
    Newcomb M; Aebisher D; Shen R; Chandrasena RE; Hollenberg PF; Coon MJ
    J Am Chem Soc; 2003 May; 125(20):6064-5. PubMed ID: 12785830
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Effects of added albumin on the kinetic isotope effect observed in the microsomal oxidative demethylation of the methoxyl group.
    Kurihara N
    Biochem Biophys Res Commun; 1993 Aug; 195(1):47-52. PubMed ID: 8363623
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Evaluation of cytochrome P450 mechanism and kinetics using kinetic deuterium isotope effects.
    Higgins L; Bennett GA; Shimoji M; Jones JP
    Biochemistry; 1998 May; 37(19):7039-46. PubMed ID: 9578592
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Generation of human metabolites of 7-ethoxycoumarin by bacterial cytochrome P450 BM3.
    Kim DH; Kim KH; Kim DH; Liu KH; Jung HC; Pan JG; Yun CH
    Drug Metab Dispos; 2008 Nov; 36(11):2166-70. PubMed ID: 18669587
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Mechanism of cytochrome P450 2D6-catalyzed sparteine metabolism in humans.
    Ebner T; Meese CO; Eichelbaum M
    Mol Pharmacol; 1995 Dec; 48(6):1078-86. PubMed ID: 8848008
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Interpretations of cytochrome P450 mechanisms from kinetic studies.
    Guengerich FP; Bell LC; Okazaki O
    Biochimie; 1995; 77(7-8):573-80. PubMed ID: 8589068
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Intramolecular isotope effects for benzylic hydroxylation of isomeric xylenes and 4,4'-dimethylbiphenyl by cytochrome P450: relationship between distance of methyl groups and masking of the intrinsic isotope effect.
    Iyer KR; Jones JP; Darbyshire JF; Trager WF
    Biochemistry; 1997 Jun; 36(23):7136-43. PubMed ID: 9188713
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Deuterium and tritium isotope effects on the microsomal N-demethylation of ethylmorphine.
    Thompson JA; Holtzman JL
    Drug Metab Dispos; 1974; 2(6):577-82. PubMed ID: 4156318
    [No Abstract]   [Full Text] [Related]  

  • 12. The mechanism of oxidation of allylic alcohols to alpha,beta-unsaturated ketones by cytochrome P450.
    Bellucci G; Chiappe C; Pucci L; Gervasi PG
    Chem Res Toxicol; 1996; 9(5):871-4. PubMed ID: 8828923
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Use of kinetic isotope effects to delineate the role of phenylalanine 87 in P450(BM-3).
    Rock DA; Boitano AE; Wahlstrom JL; Rock DA; Jones JP
    Bioorg Chem; 2002 Apr; 30(2):107-18. PubMed ID: 12020135
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Novel metabolic pathway of arylethers by cytochrome P450: cleavage of the oxygen-aromatic ring bond accompanying ipso-substitution by the oxygen atom of the active species in cytochrome P450 models and cytochrome P450.
    Ohe T; Mashino T; Hirobe M
    Arch Biochem Biophys; 1994 May; 310(2):402-9. PubMed ID: 8179325
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Reconstitution of the isobutene-forming reaction catalyzed by cytochrome P450 and P450 reductase from Rhodotorula minuta: decarboxylation with the formation of isobutene.
    Fukuda H; Fujii T; Sukita E; Tazaki M; Nagahama S; Ogawa T
    Biochem Biophys Res Commun; 1994 Jun; 201(2):516-22. PubMed ID: 8002981
    [TBL] [Abstract][Full Text] [Related]  

  • 16. An assessment of the reaction energetics for cytochrome P450-mediated reactions.
    Higgins L; Korzekwa KR; Rao S; Shou M; Jones JP
    Arch Biochem Biophys; 2001 Jan; 385(1):220-30. PubMed ID: 11361021
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Oxidation of caffeine by CYP1A2: isotope effects and metabolic switching.
    Regal KA; Kunze KL; Peter RM; Nelson SD
    Drug Metab Dispos; 2005 Dec; 33(12):1837-44. PubMed ID: 16135658
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Substrate inhibition kinetics for cytochrome P450-catalyzed reactions.
    Lin Y; Lu P; Tang C; Mei Q; Sandig G; Rodrigues AD; Rushmore TH; Shou M
    Drug Metab Dispos; 2001 Apr; 29(4 Pt 1):368-74. PubMed ID: 11259318
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Stereoselectivity and isotope effects associated with cytochrome P450-catalyzed oxidation of (S)-nicotine. The possibility of initial hydrogen atom abstraction in the formation of the delta 1', 5-nicotinium ion.
    Carlson TJ; Jones JP; Peterson L; Castagnoli N; Iyer KR; Trager WF
    Drug Metab Dispos; 1995 Jul; 23(7):749-56. PubMed ID: 7587964
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Substrate probe for the mechanism of aromatic hydroxylation catalyzed by cytochrome P450.
    Darbyshire JF; Iyer KR; Grogan J; Korzekwa KR; Trager WF
    Drug Metab Dispos; 1996 Sep; 24(9):1038-45. PubMed ID: 8886617
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 4.