These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

127 related articles for article (PubMed ID: 33261314)

  • 1. Biologic-like In Vivo Efficacy with Small Molecule Inhibitors of TNFα Identified Using Scaffold Hopping and Structure-Based Drug Design Approaches.
    Xiao HY; Li N; Duan JJ; Jiang B; Lu Z; Ngu K; Tino J; Kopcho LM; Lu H; Chen J; Tebben AJ; Sheriff S; Chang CY; Yanchunas J; Calambur D; Gao M; Shuster DJ; Susulic V; Xie JH; Guarino VR; Wu DR; Gregor KR; Goldstine CB; Hynes J; Macor JE; Salter-Cid L; Burke JR; Shaw PJ; Dhar TGM
    J Med Chem; 2020 Dec; 63(23):15050-15071. PubMed ID: 33261314
    [TBL] [Abstract][Full Text] [Related]  

  • 2. 1,7-Naphthyridine 1-oxides as novel potent and selective inhibitors of p38 mitogen activated protein kinase.
    Lumeras W; Vidal L; Vidal B; Balagué C; Orellana A; Maldonado M; Domínguez M; Segarra V; Caturla F
    J Med Chem; 2011 Nov; 54(22):7899-910. PubMed ID: 21999461
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Inhibition of Tpl2 kinase and TNF-alpha production with 1,7-naphthyridine-3-carbonitriles: synthesis and structure-activity relationships.
    Gavrin LK; Green N; Hu Y; Janz K; Kaila N; Li HQ; Tam SY; Thomason JR; Gopalsamy A; Ciszewski G; Cuozzo JW; Hall JP; Hsu S; Telliez JB; Lin LL
    Bioorg Med Chem Lett; 2005 Dec; 15(23):5288-92. PubMed ID: 16165349
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Pharmacokinetics and pharmacodynamics of DPC 333 ((2R)-2-((3R)-3-amino-3{4-[2-methyl-4-quinolinyl) methoxy] phenyl}-2-oxopyrrolidinyl)-N-hydroxy-4-methylpentanamide)), a potent and selective inhibitor of tumor necrosis factor alpha-converting enzyme in rodents, dogs, chimpanzees, and humans.
    Qian M; Bai SA; Brogdon B; Wu JT; Liu RQ; Covington MB; Vaddi K; Newton RC; Fossler MJ; Garner CE; Deng Y; Maduskuie T; Trzaskos J; Duan JJ; Decicco CP; Christ DD
    Drug Metab Dispos; 2007 Oct; 35(10):1916-25. PubMed ID: 17656469
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Novel tumor necrosis factor-α (TNF-α) inhibitors from small molecule library screening for their therapeutic activity profiles against rheumatoid arthritis using target-driven approaches and binary QSAR models.
    Zaka M; Abbasi BH; Durdagi S
    J Biomol Struct Dyn; 2019 Jun; 37(9):2464-2476. PubMed ID: 30047845
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Novel inhibitor of p38 MAP kinase as an anti-TNF-alpha drug: discovery of N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a potent and orally active anti-rheumatoid arthritis agent.
    Miwatashi S; Arikawa Y; Kotani E; Miyamoto M; Naruo K; Kimura H; Tanaka T; Asahi S; Ohkawa S
    J Med Chem; 2005 Sep; 48(19):5966-79. PubMed ID: 16162000
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structure-activity relationships and pharmacokinetic parameters of quinoline acylsulfonamides as potent and selective antagonists of the EP(4) receptor.
    Burch JD; Belley M; Fortin R; Deschênes D; Girard M; Colucci J; Farand J; Therien AG; Mathieu MC; Denis D; Vigneault E; Lévesque JF; Gagné S; Wrona M; Xu D; Clark P; Rowland S; Han Y
    Bioorg Med Chem Lett; 2008 Mar; 18(6):2048-54. PubMed ID: 18291643
    [TBL] [Abstract][Full Text] [Related]  

  • 8. 6-Benzylamino 4-oxo-1,4-dihydro-1,8-naphthyridines and 4-oxo-1,4-dihydroquinolines as HIV integrase inhibitors.
    Nagasawa JY; Song J; Chen H; Kim HW; Blazel J; Ouk S; Groschel B; Borges V; Ong V; Yeh LT; Girardet JL; Vernier JM; Raney AK; Pinkerton AB
    Bioorg Med Chem Lett; 2011 Jan; 21(2):760-3. PubMed ID: 21185178
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Design and Synthesis of a Novel and Selective Kappa Opioid Receptor (KOR) Antagonist (BTRX-335140).
    Guerrero M; Urbano M; Kim EK; Gamo AM; Riley S; Abgaryan L; Leaf N; Van Orden LJ; Brown SJ; Xie JY; Porreca F; Cameron MD; Rosen H; Roberts E
    J Med Chem; 2019 Feb; 62(4):1761-1780. PubMed ID: 30707578
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Trivalent soluble TNF Receptor, a potent TNF-α antagonist for the treatment collagen-induced arthritis.
    Cui X; Chang L; Li Y; Lv Q; Wang F; Lin Y; Li W; Meade JD; Walden JC; Liang P
    Sci Rep; 2018 May; 8(1):7327. PubMed ID: 29743640
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design.
    Dietrich JD; Longenecker KL; Wilson NS; Goess C; Panchal SC; Swann SL; Petros AM; Hobson AD; Ihle D; Song D; Richardson P; Comess KM; Cox PB; Dombrowski A; Sarris K; Donnelly-Roberts DL; Duignan DB; Gomtsyan A; Jung P; Krueger AC; Mathieu S; McClure A;