BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

118 related articles for article (PubMed ID: 33261899)

  • 1. Targeting the K
    van Veldhoven JPD; Campostrini G; van Gessel CJE; Ward-van Oostwaard D; Liu R; Mummery CL; Bellin M; IJzerman AP
    Eur J Med Chem; 2021 Feb; 212():113033. PubMed ID: 33261899
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis and biological evaluation of negative allosteric modulators of the Kv11.1(hERG) channel.
    Yu Z; van Veldhoven JP; 't Hart IM; Kopf AH; Heitman LH; IJzerman AP
    Eur J Med Chem; 2015 Dec; 106():50-9. PubMed ID: 26519929
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Allosteric modulators of the hERG K(+) channel: radioligand binding assays reveal allosteric characteristics of dofetilide analogs.
    Yu Z; Klaasse E; Heitman LH; Ijzerman AP
    Toxicol Appl Pharmacol; 2014 Jan; 274(1):78-86. PubMed ID: 24200993
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Functional Impact of BeKm-1, a High-Affinity hERG Blocker, on Cardiomyocytes Derived from Human-Induced Pluripotent Stem Cells.
    De Waard S; Montnach J; Ribeiro B; Nicolas S; Forest V; Charpentier F; Mangoni ME; Gaborit N; Ronjat M; Loussouarn G; Lemarchand P; De Waard M
    Int J Mol Sci; 2020 Sep; 21(19):. PubMed ID: 32998413
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Allosteric Modulation of Kv11.1 (hERG) Channels Protects Against Drug-Induced Ventricular Arrhythmias.
    Yu Z; Liu J; van Veldhoven JP; IJzerman AP; Schalij MJ; Pijnappels DA; Heitman LH; de Vries AA
    Circ Arrhythm Electrophysiol; 2016 Apr; 9(4):e003439. PubMed ID: 27071825
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Exploring chemical substructures essential for HERG k(+) channel blockade by synthesis and biological evaluation of dofetilide analogues.
    ; Guo D; Klaasse E; de Vries H; Brussee J; Nalos L; Rook MB; Vos MA; van der Heyden MA; Ijzerman AP
    ChemMedChem; 2009 Oct; 4(10):1722-32. PubMed ID: 19725081
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Strategies to reduce HERG K+ channel blockade. Exploring heteroaromaticity and rigidity in novel pyridine analogues of dofetilide.
    Carvalho JF; Louvel J; Doornbos ML; Klaasse E; Yu Z; Brussee J; IJzerman AP
    J Med Chem; 2013 Apr; 56(7):2828-40. PubMed ID: 23473309
    [TBL] [Abstract][Full Text] [Related]  

  • 8. LUF7244 plus Dofetilide Rescues Aberrant K
    Qile M; Ji Y; Golden TD; Houtman MJC; Romunde F; Fransen D; van Ham WB; IJzerman AP; January CT; Heitman LH; Stary-Weinzinger A; Delisle BP; van der Heyden MAG
    Mol Pharmacol; 2020 Jun; 97(6):355-364. PubMed ID: 32241959
    [TBL] [Abstract][Full Text] [Related]  

  • 9. TSSF-hERG: A machine-learning-based hERG potassium channel-specific scoring function for chemical cardiotoxicity prediction.
    Meng J; Zhang L; Wang L; Li S; Xie D; Zhang Y; Liu H
    Toxicology; 2021 Dec; 464():153018. PubMed ID: 34757159
    [TBL] [Abstract][Full Text] [Related]  

  • 10. LUF7244, an allosteric modulator/activator of K
    Qile M; Beekman HDM; Sprenkeler DJ; Houtman MJC; van Ham WB; Stary-Weinzinger A; Beyl S; Hering S; van den Berg DJ; de Lange ECM; Heitman LH; IJzerman AP; Vos MA; van der Heyden MAG
    Br J Pharmacol; 2019 Oct; 176(19):3871-3885. PubMed ID: 31339551
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Fluorescently labeled analogues of dofetilide as high-affinity fluorescence polarization ligands for the human ether-a-go-go-related gene (hERG) channel.
    Singleton DH; Boyd H; Steidl-Nichols JV; Deacon M; Groot MJ; Price D; Nettleton DO; Wallace NK; Troutman MD; Williams C; Boyd JG
    J Med Chem; 2007 Jun; 50(13):2931-41. PubMed ID: 17536794
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Molecular determinants of loperamide and N-desmethyl loperamide binding in the hERG cardiac K
    Vaz RJ; Kang J; Luo Y; Rampe D
    Bioorg Med Chem Lett; 2018 Feb; 28(3):446-451. PubMed ID: 29274816
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The [3H]dofetilide binding assay is a predictive screening tool for hERG blockade and proarrhythmia: Comparison of intact cell and membrane preparations and effects of altering [K+]o.
    Diaz GJ; Daniell K; Leitza ST; Martin RL; Su Z; McDermott JS; Cox BF; Gintant GA
    J Pharmacol Toxicol Methods; 2004; 50(3):187-99. PubMed ID: 15519905
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Characterization and structure-activity relationship of natural flavonoids as hERG K
    Sun X; Xu B; Xue Y; Li H; Zhang H; Zhang Y; Kang L; Zhang X; Zhang J; Jia Z; Zhang X
    Int Immunopharmacol; 2017 Apr; 45():187-193. PubMed ID: 28235721
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A new hERG allosteric modulator rescues genetic and drug-induced long-QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells.
    Sala L; Yu Z; Ward-van Oostwaard D; van Veldhoven JP; Moretti A; Laugwitz KL; Mummery CL; IJzerman AP; Bellin M
    EMBO Mol Med; 2016 Sep; 8(9):1065-81. PubMed ID: 27470144
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structure-Affinity Relationships (SARs) and Structure-Kinetics Relationships (SKRs) of Kv11.1 Blockers.
    Yu Z; van Veldhoven JP; Louvel J; 't Hart IM; Rook MB; van der Heyden MA; Heitman LH; IJzerman AP
    J Med Chem; 2015 Aug; 58(15):5916-29. PubMed ID: 26125327
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Facilitation of
    Furutani K; Tsumoto K; Chen IS; Handa K; Yamakawa Y; Sack JT; Kurachi Y
    J Gen Physiol; 2019 Feb; 151(2):214-230. PubMed ID: 30674563
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Cryo-EM Structure of K
    Asai T; Adachi N; Moriya T; Oki H; Maru T; Kawasaki M; Suzuki K; Chen S; Ishii R; Yonemori K; Igaki S; Yasuda S; Ogasawara S; Senda T; Murata T
    Structure; 2021 Mar; 29(3):203-212.e4. PubMed ID: 33450182
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Compilation and physicochemical classification analysis of a diverse hERG inhibition database.
    Didziapetris R; Lanevskij K
    J Comput Aided Mol Des; 2016 Dec; 30(12):1175-1188. PubMed ID: 27783199
    [TBL] [Abstract][Full Text] [Related]  

  • 20. [3H]dofetilide binding in SHSY5Y and HEK293 cells expressing a HERG-like K+ channel?
    Finlayson K; Pennington AJ; Kelly JS
    Eur J Pharmacol; 2001 Feb; 412(3):203-12. PubMed ID: 11166283
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.