These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
4. Discovery of Novel Pyrazole-Based Selective Aldosterone Synthase (CYP11B2) Inhibitors: A New Template to Coordinate the Heme-Iron Motif of CYP11B2. Sakakibara R; Sasaki W; Onda Y; Yamaguchi M; Ushirogochi H; Hiraga Y; Sato K; Nishio M; Egi Y; Takedomi K; Shimizu H; Ohbora T; Akahoshi F J Med Chem; 2018 Jul; 61(13):5594-5608. PubMed ID: 29878770 [TBL] [Abstract][Full Text] [Related]
5. A novel aldosterone synthase inhibitor ameliorates mortality in pressure-overload mice with heart failure. Furuzono S; Meguro M; Miyauchi S; Inoue S; Homma T; Yamada K; Tagawa YI; Nara F; Nagayama T Eur J Pharmacol; 2017 Jan; 795():58-65. PubMed ID: 27915044 [TBL] [Abstract][Full Text] [Related]
6. Emerging trends in small molecule inhibitors targeting aldosterone synthase: A new paradigm in cardiovascular disease treatment. Guo C; Zhang G; Wu C; Lei Y; Wang Y; Yang J Eur J Med Chem; 2024 Aug; 274():116521. PubMed ID: 38820853 [TBL] [Abstract][Full Text] [Related]
7. Synthesis of annulated pyridines as inhibitors of aldosterone synthase (CYP11B2). Martin RE; Lehmann J; Alzieu T; Lenz M; Carnero Corrales MA; Aebi JD; Märki HP; Kuhn B; Amrein K; Mayweg AV; Britton R Org Biomol Chem; 2016 Jul; 14(25):5922-7. PubMed ID: 27245438 [TBL] [Abstract][Full Text] [Related]
9. Aldosterone synthase inhibitors in cardiovascular and renal diseases. Namsolleck P; Unger T Nephrol Dial Transplant; 2014 Feb; 29 Suppl 1():i62-i68. PubMed ID: 24493871 [TBL] [Abstract][Full Text] [Related]
10. Discovery of Potential Inhibitors of Aldosterone Synthase from Chinese Herbs Using Pharmacophore Modeling, Molecular Docking, and Molecular Dynamics Simulation Studies. Luo G; Lu F; Qiao L; Chen X; Li G; Zhang Y Biomed Res Int; 2016; 2016():4182595. PubMed ID: 27781210 [TBL] [Abstract][Full Text] [Related]
11. A patent review of aldosterone synthase inhibitors (2014-present). Wu J; Ding X; Tan X Expert Opin Ther Pat; 2022 Jan; 32(1):13-28. PubMed ID: 34365871 [TBL] [Abstract][Full Text] [Related]
12. The adrenocortical tumor cell line NCI-H295R as an in vitro screening system for the evaluation of CYP11B2 (aldosterone synthase) and CYP11B1 (steroid-11beta-hydroxylase) inhibitors. Müller-Vieira U; Angotti M; Hartmann RW J Steroid Biochem Mol Biol; 2005 Aug; 96(3-4):259-70. PubMed ID: 15985365 [TBL] [Abstract][Full Text] [Related]
13. Salt-dependent Blood Pressure in Human Aldosterone Synthase-Transgenic Mice. Gu H; Ma Z; Wang J; Zhu T; Du N; Shatara A; Yi X; Kowala MC; Du Y Sci Rep; 2017 Mar; 7(1):492. PubMed ID: 28352088 [TBL] [Abstract][Full Text] [Related]
14. Rhesus monkey model for concurrent analyses of in vivo selectivity, pharmacokinetics and pharmacodynamics of aldosterone synthase inhibitors. Cai TQ; Stribling S; Tong X; Xu L; Wisniewski T; Fontenot JA; Struthers M; Akinsanya KO J Pharmacol Toxicol Methods; 2015; 71():137-46. PubMed ID: 25304940 [TBL] [Abstract][Full Text] [Related]
15. The Aldosterone Synthase Inhibitor FAD286 is Suitable for Lowering Aldosterone Levels in ZDF Rats but not in db/db Mice. Hofmann A; Brunssen C; Peitzsch M; Balyura M; Mittag J; Frenzel A; Jannasch A; Brown NF; Weldon SM; Gueneva-Boucheva KK; Eisenhofer G; Bornstein SR; Morawietz H Horm Metab Res; 2017 Jun; 49(6):466-471. PubMed ID: 28427090 [TBL] [Abstract][Full Text] [Related]
16. The development of a whole-cell based medium throughput screening system for the discovery of human aldosterone synthase (CYP11B2) inhibitors: old drugs disclose new applications for the therapy of congestive heart failure, myocardial fibrosis and hypertension. Hakki T; Hübel K; Waldmann H; Bernhardt R J Steroid Biochem Mol Biol; 2011 May; 125(1-2):120-8. PubMed ID: 21193036 [TBL] [Abstract][Full Text] [Related]
17. Aldosterone synthase inhibitors as promising treatments for mineralocorticoid dependent cardiovascular and renal diseases. Hu Q; Yin L; Hartmann RW J Med Chem; 2014 Jun; 57(12):5011-22. PubMed ID: 24422519 [TBL] [Abstract][Full Text] [Related]
18. Aldosterone and cardiovascular disease: the heart of the matter. He BJ; Anderson ME Trends Endocrinol Metab; 2013 Jan; 24(1):21-30. PubMed ID: 23040074 [TBL] [Abstract][Full Text] [Related]
19. Discovery of N-[5-(6-Chloro-3-cyano-1-methyl-1H-indol-2-yl)-pyridin-3-ylmethyl]-ethanesulfonamide, a Cortisol-Sparing CYP11B2 Inhibitor that Lowers Aldosterone in Human Subjects. Papillon JP; Lou C; Singh AK; Adams CM; Ksander GM; Beil ME; Chen W; Leung-Chu J; Fu F; Gan L; Hu CW; Jeng AY; LaSala D; Liang G; Rigel DF; Russell KS; Vest JA; Watson C J Med Chem; 2015 Dec; 58(23):9382-94. PubMed ID: 26540564 [TBL] [Abstract][Full Text] [Related]
20. Heteroatom insertion into 3,4-dihydro-1H-quinolin-2-ones leads to potent and selective inhibitors of human and rat aldosterone synthase. Grombein CM; Hu Q; Rau S; Zimmer C; Hartmann RW Eur J Med Chem; 2015 Jan; 90():788-96. PubMed ID: 25528333 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]