BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

254 related articles for article (PubMed ID: 33277368)

  • 21. MDM2 E3 ligase activity is essential for p53 regulation and cell cycle integrity.
    Chinnam M; Xu C; Lama R; Zhang X; Cedeno CD; Wang Y; Stablewski AB; Goodrich DW; Wang X
    PLoS Genet; 2022 May; 18(5):e1010171. PubMed ID: 35588102
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Mdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligase.
    Okamoto K; Taya Y; Nakagama H
    FEBS Lett; 2009 Sep; 583(17):2710-4. PubMed ID: 19619542
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Context-dependent roles of MDMX (MDM4) and MDM2 in breast cancer proliferation and circulating tumor cells.
    Gao C; Xiao G; Piersigilli A; Gou J; Ogunwobi O; Bargonetti J
    Breast Cancer Res; 2019 Jan; 21(1):5. PubMed ID: 30642351
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Regulation of p53 by Mdm2 E3 ligase function is dispensable in embryogenesis and development, but essential in response to DNA damage.
    Tollini LA; Jin A; Park J; Zhang Y
    Cancer Cell; 2014 Aug; 26(2):235-47. PubMed ID: 25117711
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Regulation of Mdm2 protein stability and the p53 response by NEDD4-1 E3 ligase.
    Xu C; Fan CD; Wang X
    Oncogene; 2015 Jan; 34(3):281-9. PubMed ID: 24413081
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Elevated MDM2 boosts the apoptotic activity of p53-MDM2 binding inhibitors by facilitating MDMX degradation.
    Xia M; Knezevic D; Tovar C; Huang B; Heimbrook DC; Vassilev LT
    Cell Cycle; 2008 Jun; 7(11):1604-12. PubMed ID: 18520179
    [TBL] [Abstract][Full Text] [Related]  

  • 27. The MDM2 RING domain and central acidic domain play distinct roles in MDM2 protein homodimerization and MDM2-MDMX protein heterodimerization.
    Leslie PL; Ke H; Zhang Y
    J Biol Chem; 2015 May; 290(20):12941-50. PubMed ID: 25809483
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans.
    Linke K; Mace PD; Smith CA; Vaux DL; Silke J; Day CL
    Cell Death Differ; 2008 May; 15(5):841-8. PubMed ID: 18219319
    [TBL] [Abstract][Full Text] [Related]  

  • 29. ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage.
    Chen L; Gilkes DM; Pan Y; Lane WS; Chen J
    EMBO J; 2005 Oct; 24(19):3411-22. PubMed ID: 16163388
    [TBL] [Abstract][Full Text] [Related]  

  • 30. MDMX exerts its oncogenic activity via suppression of retinoblastoma protein.
    Zhang H; Hu L; Qiu W; Deng T; Zhang Y; Bergholz J; Xiao ZX
    Oncogene; 2015 Oct; 34(44):5560-9. PubMed ID: 25703327
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Auto-ubiquitination of Mdm2 enhances its substrate ubiquitin ligase activity.
    Ranaweera RS; Yang X
    J Biol Chem; 2013 Jun; 288(26):18939-46. PubMed ID: 23671280
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Mdmx promotes genomic instability independent of p53 and Mdm2.
    Carrillo AM; Bouska A; Arrate MP; Eischen CM
    Oncogene; 2015 Feb; 34(7):846-56. PubMed ID: 24608433
    [TBL] [Abstract][Full Text] [Related]  

  • 33. ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activation.
    Meulmeester E; Pereg Y; Shiloh Y; Jochemsen AG
    Cell Cycle; 2005 Sep; 4(9):1166-70. PubMed ID: 16082221
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Targeting RING domains of Mdm2-MdmX E3 complex activates apoptotic arm of the p53 pathway in leukemia/lymphoma cells.
    Wu W; Xu C; Ling X; Fan C; Buckley BP; Chernov MV; Ellis L; Li F; Muñoz IG; Wang X
    Cell Death Dis; 2015 Dec; 6(12):e2035. PubMed ID: 26720344
    [TBL] [Abstract][Full Text] [Related]  

  • 35. p53 ubiquitination: Mdm2 and beyond.
    Brooks CL; Gu W
    Mol Cell; 2006 Feb; 21(3):307-15. PubMed ID: 16455486
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Critical role for a central part of Mdm2 in the ubiquitylation of p53.
    Meulmeester E; Frenk R; Stad R; de Graaf P; Marine JC; Vousden KH; Jochemsen AG
    Mol Cell Biol; 2003 Jul; 23(14):4929-38. PubMed ID: 12832478
    [TBL] [Abstract][Full Text] [Related]  

  • 37. A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network.
    Toledo F; Krummel KA; Lee CJ; Liu CW; Rodewald LW; Tang M; Wahl GM
    Cancer Cell; 2006 Apr; 9(4):273-85. PubMed ID: 16616333
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Validation of MdmX as a therapeutic target for reactivating p53 in tumors.
    Garcia D; Warr MR; Martins CP; Brown Swigart L; Passegué E; Evan GI
    Genes Dev; 2011 Aug; 25(16):1746-57. PubMed ID: 21852537
    [TBL] [Abstract][Full Text] [Related]  

  • 39. An essential function of the extreme C-terminus of MDM2 can be provided by MDMX.
    Uldrijan S; Pannekoek WJ; Vousden KH
    EMBO J; 2007 Jan; 26(1):102-12. PubMed ID: 17159902
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Regulation of the Mdm2-p53 pathway by the ubiquitin E3 ligase MARCH7.
    Zhao K; Yang Y; Zhang G; Wang C; Wang D; Wu M; Mei Y
    EMBO Rep; 2018 Feb; 19(2):305-319. PubMed ID: 29295817
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 13.