306 related articles for article (PubMed ID: 33290831)
1. Mitochondrial protein adduct and superoxide generation are prerequisites for early activation of c-jun N-terminal kinase within the cytosol after an acetaminophen overdose in mice.
Nguyen NT; Du K; Akakpo JY; Umbaugh DS; Jaeschke H; Ramachandran A
Toxicol Lett; 2021 Mar; 338():21-31. PubMed ID: 33290831
[TBL] [Abstract][Full Text] [Related]
2. Editor's Highlight: Metformin Protects Against Acetaminophen Hepatotoxicity by Attenuation of Mitochondrial Oxidant Stress and Dysfunction.
Du K; Ramachandran A; Weemhoff JL; Chavan H; Xie Y; Krishnamurthy P; Jaeschke H
Toxicol Sci; 2016 Dec; 154(2):214-226. PubMed ID: 27562556
[TBL] [Abstract][Full Text] [Related]
3. Low Dose Acetaminophen Induces Reversible Mitochondrial Dysfunction Associated with Transient c-Jun N-Terminal Kinase Activation in Mouse Liver.
Hu J; Ramshesh VK; McGill MR; Jaeschke H; Lemasters JJ
Toxicol Sci; 2016 Mar; 150(1):204-15. PubMed ID: 26721299
[TBL] [Abstract][Full Text] [Related]
4. Purinergic receptor antagonist A438079 protects against acetaminophen-induced liver injury by inhibiting p450 isoenzymes, not by inflammasome activation.
Xie Y; Williams CD; McGill MR; Lebofsky M; Ramachandran A; Jaeschke H
Toxicol Sci; 2013 Jan; 131(1):325-35. PubMed ID: 22986947
[TBL] [Abstract][Full Text] [Related]
5. Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation.
Nakagawa H; Maeda S; Hikiba Y; Ohmae T; Shibata W; Yanai A; Sakamoto K; Ogura K; Noguchi T; Karin M; Ichijo H; Omata M
Gastroenterology; 2008 Oct; 135(4):1311-21. PubMed ID: 18700144
[TBL] [Abstract][Full Text] [Related]
6. The impact of partial manganese superoxide dismutase (SOD2)-deficiency on mitochondrial oxidant stress, DNA fragmentation and liver injury during acetaminophen hepatotoxicity.
Ramachandran A; Lebofsky M; Weinman SA; Jaeschke H
Toxicol Appl Pharmacol; 2011 Mar; 251(3):226-33. PubMed ID: 21241727
[TBL] [Abstract][Full Text] [Related]
7. Mechanisms of acetaminophen-induced cell death in primary human hepatocytes.
Xie Y; McGill MR; Dorko K; Kumer SC; Schmitt TM; Forster J; Jaeschke H
Toxicol Appl Pharmacol; 2014 Sep; 279(3):266-274. PubMed ID: 24905542
[TBL] [Abstract][Full Text] [Related]
8. Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytes.
Xie Y; McGill MR; Du K; Dorko K; Kumer SC; Schmitt TM; Ding WX; Jaeschke H
Toxicol Appl Pharmacol; 2015 Dec; 289(2):213-22. PubMed ID: 26431796
[TBL] [Abstract][Full Text] [Related]
9. Silencing glycogen synthase kinase-3beta inhibits acetaminophen hepatotoxicity and attenuates JNK activation and loss of glutamate cysteine ligase and myeloid cell leukemia sequence 1.
Shinohara M; Ybanez MD; Win S; Than TA; Jain S; Gaarde WA; Han D; Kaplowitz N
J Biol Chem; 2010 Mar; 285(11):8244-55. PubMed ID: 20061376
[TBL] [Abstract][Full Text] [Related]
10. c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity.
Gunawan BK; Liu ZX; Han D; Hanawa N; Gaarde WA; Kaplowitz N
Gastroenterology; 2006 Jul; 131(1):165-78. PubMed ID: 16831600
[TBL] [Abstract][Full Text] [Related]
11. Protein kinase C (PKC) participates in acetaminophen hepatotoxicity through c-jun-N-terminal kinase (JNK)-dependent and -independent signaling pathways.
Saberi B; Ybanez MD; Johnson HS; Gaarde WA; Han D; Kaplowitz N
Hepatology; 2014 Apr; 59(4):1543-1554. PubMed ID: 23873604
[TBL] [Abstract][Full Text] [Related]
12. Inhibitor of apoptosis signal-regulating kinase 1 protects against acetaminophen-induced liver injury.
Xie Y; Ramachandran A; Breckenridge DG; Liles JT; Lebofsky M; Farhood A; Jaeschke H
Toxicol Appl Pharmacol; 2015 Jul; 286(1):1-9. PubMed ID: 25818599
[TBL] [Abstract][Full Text] [Related]
13. 4-Methylpyrazole protects against acetaminophen hepatotoxicity in mice and in primary human hepatocytes.
Akakpo JY; Ramachandran A; Kandel SE; Ni HM; Kumer SC; Rumack BH; Jaeschke H
Hum Exp Toxicol; 2018 Dec; 37(12):1310-1322. PubMed ID: 29739258
[TBL] [Abstract][Full Text] [Related]
14. c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity.
Saito C; Lemasters JJ; Jaeschke H
Toxicol Appl Pharmacol; 2010 Jul; 246(1-2):8-17. PubMed ID: 20423716
[TBL] [Abstract][Full Text] [Related]
15. Apoptosis-inducing factor modulates mitochondrial oxidant stress in acetaminophen hepatotoxicity.
Bajt ML; Ramachandran A; Yan HM; Lebofsky M; Farhood A; Lemasters JJ; Jaeschke H
Toxicol Sci; 2011 Aug; 122(2):598-605. PubMed ID: 21572097
[TBL] [Abstract][Full Text] [Related]
16. Impaired protein adduct removal following repeat administration of subtoxic doses of acetaminophen enhances liver injury in fed mice.
Nguyen NT; Akakpo JY; Weemhoff JL; Ramachandran A; Ding WX; Jaeschke H
Arch Toxicol; 2021 Apr; 95(4):1463-1473. PubMed ID: 33458793
[TBL] [Abstract][Full Text] [Related]
17. A mitochondrial journey through acetaminophen hepatotoxicity.
Ramachandran A; Jaeschke H
Food Chem Toxicol; 2020 Jun; 140():111282. PubMed ID: 32209353
[TBL] [Abstract][Full Text] [Related]
18. Dual Role of Epidermal Growth Factor Receptor in Liver Injury and Regeneration after Acetaminophen Overdose in Mice.
Bhushan B; Chavan H; Borude P; Xie Y; Du K; McGill MR; Lebofsky M; Jaeschke H; Krishnamurthy P; Apte U
Toxicol Sci; 2017 Feb; 155(2):363-378. PubMed ID: 28123000
[TBL] [Abstract][Full Text] [Related]
19. Lower susceptibility of female mice to acetaminophen hepatotoxicity: Role of mitochondrial glutathione, oxidant stress and c-jun N-terminal kinase.
Du K; Williams CD; McGill MR; Jaeschke H
Toxicol Appl Pharmacol; 2014 Nov; 281(1):58-66. PubMed ID: 25218290
[TBL] [Abstract][Full Text] [Related]
20. Acetaminophen hepatotoxicity: A mitochondrial perspective.
Ramachandran A; Jaeschke H
Adv Pharmacol; 2019; 85():195-219. PubMed ID: 31307587
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
