BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

365 related articles for article (PubMed ID: 33296223)

  • 1. Cholesterol-lowering drugs reduce APP processing to Aβ by inducing APP dimerization.
    Langness VF; van der Kant R; Das U; Wang L; Chaves RDS; Goldstein LSB
    Mol Biol Cell; 2021 Feb; 32(3):247-259. PubMed ID: 33296223
    [TBL] [Abstract][Full Text] [Related]  

  • 2. APP-BACE1 Interaction and Intracellular Localization Regulate Aβ Production in iPSC-Derived Cortical Neurons.
    Roselli S; Satir TM; Camacho R; Fruhwürth S; Bergström P; Zetterberg H; Agholme L
    Cell Mol Neurobiol; 2023 Oct; 43(7):3653-3668. PubMed ID: 37355492
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.
    Deng Y; Wang Z; Wang R; Zhang X; Zhang S; Wu Y; Staufenbiel M; Cai F; Song W
    Eur J Neurosci; 2013 Jun; 37(12):1962-9. PubMed ID: 23773065
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Decrease in brain soluble amyloid precursor protein β (sAPPβ) in Alzheimer's disease cortex.
    Wu G; Sankaranarayanan S; Hsieh SH; Simon AJ; Savage MJ
    J Neurosci Res; 2011 Jun; 89(6):822-32. PubMed ID: 21433051
    [TBL] [Abstract][Full Text] [Related]  

  • 5. BACE1 Cleavage Site Selection Critical for Amyloidogenesis and Alzheimer's Pathogenesis.
    Zhang S; Wang Z; Cai F; Zhang M; Wu Y; Zhang J; Song W
    J Neurosci; 2017 Jul; 37(29):6915-6925. PubMed ID: 28626014
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Alternative Selection of β-Site APP-Cleaving Enzyme 1 (BACE1) Cleavage Sites in Amyloid β-Protein Precursor (APP) Harboring Protective and Pathogenic Mutations within the Aβ Sequence.
    Kimura A; Hata S; Suzuki T
    J Biol Chem; 2016 Nov; 291(46):24041-24053. PubMed ID: 27687728
    [TBL] [Abstract][Full Text] [Related]  

  • 7. BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice.
    Kim W; Ma L; Lomoio S; Willen R; Lombardo S; Dong J; Haydon PG; Tesco G
    Mol Neurodegener; 2018 Feb; 13(1):6. PubMed ID: 29391027
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The neuronal-specific isoform of BIN1 regulates β-secretase cleavage of APP and Aβ generation in a RIN3-dependent manner.
    Bhattacharyya R; Teves CAF; Long A; Hofert M; Tanzi RE
    Sci Rep; 2022 Mar; 12(1):3486. PubMed ID: 35241726
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Regulation of Synaptic Amyloid-β Generation through BACE1 Retrograde Transport in a Mouse Model of Alzheimer's Disease.
    Ye X; Feng T; Tammineni P; Chang Q; Jeong YY; Margolis DJ; Cai H; Kusnecov A; Cai Q
    J Neurosci; 2017 Mar; 37(10):2639-2655. PubMed ID: 28159908
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Molecular mechanisms of Alzheimer disease protection by the A673T allele of amyloid precursor protein.
    Maloney JA; Bainbridge T; Gustafson A; Zhang S; Kyauk R; Steiner P; van der Brug M; Liu Y; Ernst JA; Watts RJ; Atwal JK
    J Biol Chem; 2014 Nov; 289(45):30990-1000. PubMed ID: 25253696
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Cross-linking of cell surface amyloid precursor protein leads to increased β-amyloid peptide production in hippocampal neurons: implications for Alzheimer's disease.
    Lefort R; Pozueta J; Shelanski M
    J Neurosci; 2012 Aug; 32(31):10674-85. PubMed ID: 22855816
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models.
    Natunen T; Takalo M; Kemppainen S; Leskelä S; Marttinen M; Kurkinen KMA; Pursiheimo JP; Sarajärvi T; Viswanathan J; Gabbouj S; Solje E; Tahvanainen E; Pirttimäki T; Kurki M; Paananen J; Rauramaa T; Miettinen P; Mäkinen P; Leinonen V; Soininen H; Airenne K; Tanzi RE; Tanila H; Haapasalo A; Hiltunen M
    Neurobiol Dis; 2016 Jan; 85():187-205. PubMed ID: 26563932
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The Golgi-Localized γ-Ear-Containing ARF-Binding (GGA) Proteins Alter Amyloid-β Precursor Protein (APP) Processing through Interaction of Their GAE Domain with the Beta-Site APP Cleaving Enzyme 1 (BACE1).
    von Einem B; Wahler A; Schips T; Serrano-Pozo A; Proepper C; Boeckers TM; Rueck A; Wirth T; Hyman BT; Danzer KM; Thal DR; von Arnim CA
    PLoS One; 2015; 10(6):e0129047. PubMed ID: 26053850
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Altered amyloid-beta metabolism and deposition in genomic-based beta-secretase transgenic mice.
    Chiocco MJ; Kulnane LS; Younkin L; Younkin S; Evin G; Lamb BT
    J Biol Chem; 2004 Dec; 279(50):52535-42. PubMed ID: 15452128
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by γ-Secretase and Amyloid-β Peptide Production.
    Gerber H; Wu F; Dimitrov M; Garcia Osuna GM; Fraering PC
    J Biol Chem; 2017 Mar; 292(9):3751-3767. PubMed ID: 28096459
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Reduction of the expression of the late-onset Alzheimer's disease (AD) risk-factor
    Andrew RJ; De Rossi P; Nguyen P; Kowalski HR; Recupero AJ; Guerbette T; Krause SV; Rice RC; Laury-Kleintop L; Wagner SL; Thinakaran G
    J Biol Chem; 2019 Mar; 294(12):4477-4487. PubMed ID: 30692199
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Swedish mutant APP-based BACE1 binding site peptide reduces APP β-cleavage and cerebral Aβ levels in Alzheimer's mice.
    Li S; Hou H; Mori T; Sawmiller D; Smith A; Tian J; Wang Y; Giunta B; Sanberg PR; Zhang S; Tan J
    Sci Rep; 2015 Jun; 5():11322. PubMed ID: 26091071
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The role of membrane trafficking in the processing of amyloid precursor protein and production of amyloid peptides in Alzheimer's disease.
    Tan JZA; Gleeson PA
    Biochim Biophys Acta Biomembr; 2019 Apr; 1861(4):697-712. PubMed ID: 30639513
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Endoplasmic reticulum stress induces Alzheimer disease-like phenotypes in the neuron derived from the induced pluripotent stem cell with D678H mutation on amyloid precursor protein.
    Devina T; Wong YH; Hsiao CW; Li YJ; Lien CC; Cheng IH
    J Neurochem; 2022 Oct; 163(1):26-39. PubMed ID: 35943292
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Enhanced cleavage of APP by co-expressed Bace1 alters the distribution of APP and its fragments in neuronal and non-neuronal cells.
    Aow J; Huang TR; Thinakaran G; Koo EH
    Mol Neurobiol; 2022 May; 59(5):3073-3090. PubMed ID: 35266114
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 19.