BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

324 related articles for article (PubMed ID: 33301977)

  • 1. Allosteric binding sites at the receptor-lipid bilayer interface: novel targets for GPCR drug discovery.
    Wang Y; Yu Z; Xiao W; Lu S; Zhang J
    Drug Discov Today; 2021 Mar; 26(3):690-703. PubMed ID: 33301977
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The impact of cryo-EM on determining allosteric modulator-bound structures of G protein-coupled receptors.
    Zhang L; Mobbs JI; May LT; Glukhova A; Thal DM
    Curr Opin Struct Biol; 2023 Apr; 79():102560. PubMed ID: 36848776
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Does the Lipid Bilayer Orchestrate Access and Binding of Ligands to Transmembrane Orthosteric/Allosteric Sites of G Protein-Coupled Receptors?
    Szlenk CT; Gc JB; Natesan S
    Mol Pharmacol; 2019 Nov; 96(5):527-541. PubMed ID: 30967440
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Bitopic Ligands and Metastable Binding Sites: Opportunities for G Protein-Coupled Receptor (GPCR) Medicinal Chemistry.
    Fronik P; Gaiser BI; Sejer Pedersen D
    J Med Chem; 2017 May; 60(10):4126-4134. PubMed ID: 28140580
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Strategies for the identification of allosteric modulators of G-protein-coupled receptors.
    Burford NT; Watson J; Bertekap R; Alt A
    Biochem Pharmacol; 2011 Mar; 81(6):691-702. PubMed ID: 21184747
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Pharmacologically targeting intracellular allosteric sites of GPCRs for drug discovery.
    Zhang M; Lan X; Li X; Lu S
    Drug Discov Today; 2023 Dec; 28(12):103803. PubMed ID: 37852356
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Is there a common allosteric binding site for G-protein coupled receptors?
    Malik F; Li Z
    J Comput Aided Mol Des; 2022 Jun; 36(6):405-413. PubMed ID: 35507106
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Pharmacology of Free Fatty Acid Receptors and Their Allosteric Modulators.
    Grundmann M; Bender E; Schamberger J; Eitner F
    Int J Mol Sci; 2021 Feb; 22(4):. PubMed ID: 33578942
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Covalent allosteric modulation: An emerging strategy for GPCRs drug discovery.
    Bian Y; Jun JJ; Cuyler J; Xie XQ
    Eur J Med Chem; 2020 Nov; 206():112690. PubMed ID: 32818870
    [TBL] [Abstract][Full Text] [Related]  

  • 10. GPCR Allosteric Modulator Discovery.
    Wu Y; Tong J; Ding K; Zhou Q; Zhao S
    Adv Exp Med Biol; 2019; 1163():225-251. PubMed ID: 31707706
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Allosteric modulation of GPCRs: From structural insights to in silico drug discovery.
    Persechino M; Hedderich JB; Kolb P; Hilger D
    Pharmacol Ther; 2022 Sep; 237():108242. PubMed ID: 35863587
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Small Molecule Allosteric Modulators of G-Protein-Coupled Receptors: Drug-Target Interactions.
    Lu S; Zhang J
    J Med Chem; 2019 Jan; 62(1):24-45. PubMed ID: 29457894
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Current and Future Challenges in GPCR Drug Discovery.
    Topiol S
    Methods Mol Biol; 2018; 1705():1-21. PubMed ID: 29188556
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Recent advances in drug discovery of GPCR allosteric modulators for neurodegenerative disorders.
    Lütjens R; Rocher JP
    Curr Opin Pharmacol; 2017 Feb; 32():91-95. PubMed ID: 28135635
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Allosteric Modulation of Class A GPCRs: Targets, Agents, and Emerging Concepts.
    Wold EA; Chen J; Cunningham KA; Zhou J
    J Med Chem; 2019 Jan; 62(1):88-127. PubMed ID: 30106578
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Unmasking allosteric-binding sites: novel targets for GPCR drug discovery.
    Casadó-Anguera V; Casadó V
    Expert Opin Drug Discov; 2022 Aug; 17(8):897-923. PubMed ID: 35649692
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Emerging paradigms in GPCR allostery: implications for drug discovery.
    Wootten D; Christopoulos A; Sexton PM
    Nat Rev Drug Discov; 2013 Aug; 12(8):630-44. PubMed ID: 23903222
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Allosteric Regulation of G-Protein-Coupled Receptors: From Diversity of Molecular Mechanisms to Multiple Allosteric Sites and Their Ligands.
    Shpakov AO
    Int J Mol Sci; 2023 Mar; 24(7):. PubMed ID: 37047169
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Leveraging allostery to improve G protein-coupled receptor (GPCR)-directed therapeutics: cannabinoid receptor 1 as discovery target.
    Janero DR; Thakur GA
    Expert Opin Drug Discov; 2016 Dec; 11(12):1223-1237. PubMed ID: 27712124
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Membrane Lipids Are an Integral Part of Transmembrane Allosteric Sites in GPCRs: A Case Study of Cannabinoid CB1 Receptor Bound to a Negative Allosteric Modulator, ORG27569, and Analogs.
    Obi P; Natesan S
    J Med Chem; 2022 Sep; 65(18):12240-12255. PubMed ID: 36066412
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 17.