543 related articles for article (PubMed ID: 33308480)
1. NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C.
Davis OB; Shin HR; Lim CY; Wu EY; Kukurugya M; Maher CF; Perera RM; Ordonez MP; Zoncu R
Dev Cell; 2021 Feb; 56(3):260-276.e7. PubMed ID: 33308480
[TBL] [Abstract][Full Text] [Related]
2. ER-lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann-Pick type C.
Lim CY; Davis OB; Shin HR; Zhang J; Berdan CA; Jiang X; Counihan JL; Ory DS; Nomura DK; Zoncu R
Nat Cell Biol; 2019 Oct; 21(10):1206-1218. PubMed ID: 31548609
[TBL] [Abstract][Full Text] [Related]
3. NPC1 regulates the distribution of phosphatidylinositol 4-kinases at Golgi and lysosomal membranes.
Kutchukian C; Vivas O; Casas M; Jones JG; Tiscione SA; Simó S; Ory DS; Dixon RE; Dickson EJ
EMBO J; 2021 Jul; 40(13):e105990. PubMed ID: 34019311
[TBL] [Abstract][Full Text] [Related]
4. Impaired Retromer Function in Niemann-Pick Type C Disease Is Dependent on Intracellular Cholesterol Accumulation.
Dominko K; Rastija A; Sobocanec S; Vidatic L; Meglaj S; Lovincic Babic A; Hutter-Paier B; Colombo AV; Lichtenthaler SF; Tahirovic S; Hecimovic S
Int J Mol Sci; 2021 Dec; 22(24):. PubMed ID: 34948052
[TBL] [Abstract][Full Text] [Related]
5. Targeting defective sphingosine kinase 1 in Niemann-Pick type C disease with an activator mitigates cholesterol accumulation.
Newton J; Palladino END; Weigel C; Maceyka M; Gräler MH; Senkal CE; Enriz RD; Marvanova P; Jampilek J; Lima S; Milstien S; Spiegel S
J Biol Chem; 2020 Jul; 295(27):9121-9133. PubMed ID: 32385114
[TBL] [Abstract][Full Text] [Related]
6. Trehalose enhances mitochondria deficits in human NPC1 mutant fibroblasts but disrupts mouse Purkinje cell dendritic growth ex vivo.
MacLeod CM; Yousufzai FAK; Spencer LT; Kim S; Rivera-Rosario LA; Barrera ZD; Walsh L; Krummenacher C; Carone B; Soto I
PLoS One; 2023; 18(11):e0294312. PubMed ID: 38033125
[TBL] [Abstract][Full Text] [Related]
7. Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium.
Lloyd-Evans E; Morgan AJ; He X; Smith DA; Elliot-Smith E; Sillence DJ; Churchill GC; Schuchman EH; Galione A; Platt FM
Nat Med; 2008 Nov; 14(11):1247-55. PubMed ID: 18953351
[TBL] [Abstract][Full Text] [Related]
8. Impaired proteolysis underlies autophagic dysfunction in Niemann-Pick type C disease.
Elrick MJ; Yu T; Chung C; Lieberman AP
Hum Mol Genet; 2012 Nov; 21(22):4876-87. PubMed ID: 22872701
[TBL] [Abstract][Full Text] [Related]
9. Enrichment of NPC1-deficient cells with the lipid LBPA stimulates autophagy, improves lysosomal function, and reduces cholesterol storage.
Ilnytska O; Lai K; Gorshkov K; Schultz ML; Tran BN; Jeziorek M; Kunkel TJ; Azaria RD; McLoughlin HS; Waghalter M; Xu Y; Schlame M; Altan-Bonnet N; Zheng W; Lieberman AP; Dobrowolski R; Storch J
J Biol Chem; 2021 Jul; 297(1):100813. PubMed ID: 34023384
[TBL] [Abstract][Full Text] [Related]
10. Beneficial effects of primidone in Niemann-Pick disease type C (NPC)-model cells and mice: Reduction of unesterified cholesterol levels in cells and extension of lifespan in mice.
Ashikawa H; Mogi H; Honda T; Nakamura H; Murayama T
Eur J Pharmacol; 2021 Apr; 896():173907. PubMed ID: 33503462
[TBL] [Abstract][Full Text] [Related]
11. Mitochondrial GSH replenishment as a potential therapeutic approach for Niemann Pick type C disease.
Torres S; Matías N; Baulies A; Nuñez S; Alarcon-Vila C; Martinez L; Nuño N; Fernandez A; Caballeria J; Levade T; Gonzalez-Franquesa A; Garcia-Rovés P; Balboa E; Zanlungo S; Fabrías G; Casas J; Enrich C; Garcia-Ruiz C; Fernández-Checa JC
Redox Biol; 2017 Apr; 11():60-72. PubMed ID: 27888692
[TBL] [Abstract][Full Text] [Related]
12. Endo-lysosomal dysfunction and neuronal-glial crosstalk in Niemann-Pick type C disease.
Malara M; Prestel M; Tahirovic S
Philos Trans R Soc Lond B Biol Sci; 2024 Apr; 379(1899):20220388. PubMed ID: 38368932
[TBL] [Abstract][Full Text] [Related]
13. Niemann-Pick C1 protein: obligatory roles for N-terminal domains and lysosomal targeting in cholesterol mobilization.
Watari H; Blanchette-Mackie EJ; Dwyer NK; Glick JM; Patel S; Neufeld EB; Brady RO; Pentchev PG; Strauss JF
Proc Natl Acad Sci U S A; 1999 Feb; 96(3):805-10. PubMed ID: 9927649
[TBL] [Abstract][Full Text] [Related]
14. Finding pathogenic commonalities between Niemann-Pick type C and other lysosomal storage disorders: Opportunities for shared therapeutic interventions.
Yañez MJ; Marín T; Balboa E; Klein AD; Alvarez AR; Zanlungo S
Biochim Biophys Acta Mol Basis Dis; 2020 Oct; 1866(10):165875. PubMed ID: 32522631
[TBL] [Abstract][Full Text] [Related]
15. Unbiased yeast screens identify cellular pathways affected in Niemann-Pick disease type C.
Colaco A; Fernández-Suárez ME; Shepherd D; Gal L; Bibi C; Chuartzman S; Diot A; Morten K; Eden E; Porter FD; Poulton J; Platt N; Schuldiner M; Platt FM
Life Sci Alliance; 2020 Jul; 3(7):. PubMed ID: 32487688
[TBL] [Abstract][Full Text] [Related]
16. Hydroxypropyl-beta and -gamma cyclodextrins rescue cholesterol accumulation in Niemann-Pick C1 mutant cell via lysosome-associated membrane protein 1.
Singhal A; Szente L; Hildreth JEK; Song B
Cell Death Dis; 2018 Oct; 9(10):1019. PubMed ID: 30282967
[TBL] [Abstract][Full Text] [Related]
17. Lipid-mediated motor-adaptor sequestration impairs axonal lysosome delivery leading to autophagic stress and dystrophy in Niemann-Pick type C.
Roney JC; Li S; Farfel-Becker T; Huang N; Sun T; Xie Y; Cheng XT; Lin MY; Platt FM; Sheng ZH
Dev Cell; 2021 May; 56(10):1452-1468.e8. PubMed ID: 33878344
[TBL] [Abstract][Full Text] [Related]
18. NPC1-dependent alterations in K
Casas M; Murray KD; Hino K; Vierra NC; Simó S; Trimmer JS; Dixon RE; Dickson EJ
Nat Commun; 2023 Jul; 14(1):4553. PubMed ID: 37507375
[TBL] [Abstract][Full Text] [Related]
19. Endosomal/lysosomal processing of gangliosides affects neuronal cholesterol sequestration in Niemann-Pick disease type C.
Zhou S; Davidson C; McGlynn R; Stephney G; Dobrenis K; Vanier MT; Walkley SU
Am J Pathol; 2011 Aug; 179(2):890-902. PubMed ID: 21708114
[TBL] [Abstract][Full Text] [Related]
20. NPC1-like phenotype, with intracellular cholesterol accumulation and altered mTORC1 signaling in models of Parkinson's disease.
Caria I; Nunes MJ; Ciraci V; Carvalho AN; Ranito C; Santos SG; Gama MJ; Castro-Caldas M; Rodrigues CMP; Ruas JL; Rodrigues E
Biochim Biophys Acta Mol Basis Dis; 2024 Feb; 1870(2):166980. PubMed ID: 38061599
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
