137 related articles for article (PubMed ID: 33433933)
1. p53-mediated regulation of mitochondrial dynamics plays a pivotal role in the senescence of various normal cells as well as cancer cells.
Kim YY; Um JH; Shin DJ; Jeong DJ; Hong YB; Yun J
FASEB J; 2021 Feb; 35(2):e21319. PubMed ID: 33433933
[TBL] [Abstract][Full Text] [Related]
2. p53 regulates mitochondrial dynamics by inhibiting Drp1 translocation into mitochondria during cellular senescence.
Kim YY; Um JH; Yoon JH; Lee DY; Lee YJ; Kim DH; Park JI; Yun J
FASEB J; 2020 Feb; 34(2):2451-2464. PubMed ID: 31908078
[TBL] [Abstract][Full Text] [Related]
3. Reduced transcriptional activity in the p53 pathway of senescent cells revealed by the MDM2 antagonist nutlin-3.
Huang B; Vassilev LT
Aging (Albany NY); 2009 Sep; 1(10):845-54. PubMed ID: 20157557
[TBL] [Abstract][Full Text] [Related]
4. Activation of p53 by Nutlin-3a, an antagonist of MDM2, induces apoptosis and cellular senescence in adult T-cell leukemia cells.
Hasegawa H; Yamada Y; Iha H; Tsukasaki K; Nagai K; Atogami S; Sugahara K; Tsuruda K; Ishizaki A; Kamihira S
Leukemia; 2009 Nov; 23(11):2090-101. PubMed ID: 19710698
[TBL] [Abstract][Full Text] [Related]
5. Cellular quiescence caused by the Mdm2 inhibitor nutlin-3A.
Korotchkina LG; Demidenko ZN; Gudkov AV; Blagosklonny MV
Cell Cycle; 2009 Nov; 8(22):3777-81. PubMed ID: 19855165
[TBL] [Abstract][Full Text] [Related]
6. Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence.
Kumamoto K; Spillare EA; Fujita K; Horikawa I; Yamashita T; Appella E; Nagashima M; Takenoshita S; Yokota J; Harris CC
Cancer Res; 2008 May; 68(9):3193-203. PubMed ID: 18451145
[TBL] [Abstract][Full Text] [Related]
7. Inhibition of DYRK1A-EGFR axis by p53-MDM2 cascade mediates the induction of cellular senescence.
Xu X; Liu Q; Zhang C; Ren S; Xu L; Zhao Z; Dou H; Li P; Zhang X; Gong Y; Shao C
Cell Death Dis; 2019 Mar; 10(4):282. PubMed ID: 30910997
[TBL] [Abstract][Full Text] [Related]
8. Awakening p53 in senescent cells using nutlin-3.
Schug TT
Aging (Albany NY); 2009 Oct; 1(10):842-4. PubMed ID: 20157556
[No Abstract] [Full Text] [Related]
9. Cooperation of Nutlin-3a and a Wip1 inhibitor to induce p53 activity.
Sriraman A; Radovanovic M; Wienken M; Najafova Z; Li Y; Dobbelstein M
Oncotarget; 2016 May; 7(22):31623-38. PubMed ID: 27183917
[TBL] [Abstract][Full Text] [Related]
10. p53 Regulates Mitochondrial Dynamics in Vascular Smooth Muscle Cell Calcification.
Phadwal K; Tang QY; Luijten I; Zhao JF; Corcoran B; Semple RK; Ganley IG; MacRae VE
Int J Mol Sci; 2023 Jan; 24(2):. PubMed ID: 36675156
[TBL] [Abstract][Full Text] [Related]
11. UBTD1 induces cellular senescence through an UBTD1-Mdm2/p53 positive feedback loop.
Zhang XW; Wang XF; Ni SJ; Qin W; Zhao LQ; Hua RX; Lu YW; Li J; Dimri GP; Guo WJ
J Pathol; 2015 Mar; 235(4):656-67. PubMed ID: 25382750
[TBL] [Abstract][Full Text] [Related]
12. Induction of p53-dependent senescence by the MDM2 antagonist nutlin-3a in mouse cells of fibroblast origin.
Efeyan A; Ortega-Molina A; Velasco-Miguel S; Herranz D; Vassilev LT; Serrano M
Cancer Res; 2007 Aug; 67(15):7350-7. PubMed ID: 17671205
[TBL] [Abstract][Full Text] [Related]
13. E2F-1 transcriptional activity is a critical determinant of Mdm2 antagonist-induced apoptosis in human tumor cell lines.
Kitagawa M; Aonuma M; Lee SH; Fukutake S; McCormick F
Oncogene; 2008 Sep; 27(40):5303-14. PubMed ID: 18521084
[TBL] [Abstract][Full Text] [Related]
14. The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway.
Korotchkina LG; Leontieva OV; Bukreeva EI; Demidenko ZN; Gudkov AV; Blagosklonny MV
Aging (Albany NY); 2010 Jun; 2(6):344-52. PubMed ID: 20606252
[TBL] [Abstract][Full Text] [Related]
15. Pharmacologic p53 activation blocks cell cycle progression but fails to induce senescence in epithelial cancer cells.
Huang B; Deo D; Xia M; Vassilev LT
Mol Cancer Res; 2009 Sep; 7(9):1497-509. PubMed ID: 19737973
[TBL] [Abstract][Full Text] [Related]
16. Cooperation between p21 and Akt is required for p53-dependent cellular senescence.
Kim YY; Jee HJ; Um JH; Kim YM; Bae SS; Yun J
Aging Cell; 2017 Oct; 16(5):1094-1103. PubMed ID: 28691365
[TBL] [Abstract][Full Text] [Related]
17. Small-molecule MDM2 antagonists attenuate the senescence-associated secretory phenotype.
Wiley CD; Schaum N; Alimirah F; Lopez-Dominguez JA; Orjalo AV; Scott G; Desprez PY; Benz C; Davalos AR; Campisi J
Sci Rep; 2018 Feb; 8(1):2410. PubMed ID: 29402901
[TBL] [Abstract][Full Text] [Related]
18. 20(S)-ginsenoside Rg3 promotes senescence and apoptosis in gallbladder cancer cells via the p53 pathway.
Zhang F; Li M; Wu X; Hu Y; Cao Y; Wang X; Xiang S; Li H; Jiang L; Tan Z; Lu W; Weng H; Shu Y; Gong W; Wang X; Zhang Y; Shi W; Dong P; Gu J; Liu Y
Drug Des Devel Ther; 2015; 9():3969-87. PubMed ID: 26309394
[TBL] [Abstract][Full Text] [Related]
19. p53-regulated autophagy is controlled by glycolysis and determines cell fate.
Duan L; Perez RE; Davaadelger B; Dedkova EN; Blatter LA; Maki CG
Oncotarget; 2015 Sep; 6(27):23135-56. PubMed ID: 26337205
[TBL] [Abstract][Full Text] [Related]
20. Mitochondrial stress induces cellular senescence in an mTORC1-dependent manner.
Nacarelli T; Azar A; Sell C
Free Radic Biol Med; 2016 Jun; 95():133-54. PubMed ID: 27016071
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]