244 related articles for article (PubMed ID: 33436626)
1. Structural insights into TSC complex assembly and GAP activity on Rheb.
Yang H; Yu Z; Chen X; Li J; Li N; Cheng J; Gao N; Yuan HX; Ye D; Guan KL; Xu Y
Nat Commun; 2021 Jan; 12(1):339. PubMed ID: 33436626
[TBL] [Abstract][Full Text] [Related]
2. Architecture of the Tuberous Sclerosis Protein Complex.
Ramlaul K; Fu W; Li H; de Martin Garrido N; He L; Trivedi M; Cui W; Aylett CHS; Wu G
J Mol Biol; 2021 Jan; 433(2):166743. PubMed ID: 33307091
[TBL] [Abstract][Full Text] [Related]
3. Structure of the TSC2 GAP Domain: Mechanistic Insight into Catalysis and Pathogenic Mutations.
Hansmann P; Brückner A; Kiontke S; Berkenfeld B; Seebohm G; Brouillard P; Vikkula M; Jansen FE; Nellist M; Oeckinghaus A; Kümmel D
Structure; 2020 Aug; 28(8):933-942.e4. PubMed ID: 32502382
[TBL] [Abstract][Full Text] [Related]
4. TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1.
Dibble CC; Elis W; Menon S; Qin W; Klekota J; Asara JM; Finan PM; Kwiatkowski DJ; Murphy LO; Manning BD
Mol Cell; 2012 Aug; 47(4):535-46. PubMed ID: 22795129
[TBL] [Abstract][Full Text] [Related]
5. Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity.
Li Y; Inoki K; Guan KL
Mol Cell Biol; 2004 Sep; 24(18):7965-75. PubMed ID: 15340059
[TBL] [Abstract][Full Text] [Related]
6. CBAP regulates the function of Akt-associated TSC protein complexes to modulate mTORC1 signaling.
Liao WT; Chiang YJ; Yang-Yen HF; Hsu LC; Chang ZF; Yen JJY
J Biol Chem; 2023 Dec; 299(12):105455. PubMed ID: 37949232
[TBL] [Abstract][Full Text] [Related]
7. Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb.
Tee AR; Manning BD; Roux PP; Cantley LC; Blenis J
Curr Biol; 2003 Aug; 13(15):1259-68. PubMed ID: 12906785
[TBL] [Abstract][Full Text] [Related]
8. Structure of the Tuberous Sclerosis Complex 2 (TSC2) N Terminus Provides Insight into Complex Assembly and Tuberous Sclerosis Pathogenesis.
Zech R; Kiontke S; Mueller U; Oeckinghaus A; Kümmel D
J Biol Chem; 2016 Sep; 291(38):20008-20. PubMed ID: 27493206
[TBL] [Abstract][Full Text] [Related]
9. Amino Acid-Mediated Intracellular Ca
Amemiya Y; Nakamura N; Ikeda N; Sugiyama R; Ishii C; Maki M; Shibata H; Takahara T
Int J Mol Sci; 2021 Jun; 22(13):. PubMed ID: 34198993
[TBL] [Abstract][Full Text] [Related]
10. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.
Inoki K; Li Y; Xu T; Guan KL
Genes Dev; 2003 Aug; 17(15):1829-34. PubMed ID: 12869586
[TBL] [Abstract][Full Text] [Related]
11. Structural basis for the unique biological function of small GTPase RHEB.
Yu Y; Li S; Xu X; Li Y; Guan K; Arnold E; Ding J
J Biol Chem; 2005 Apr; 280(17):17093-100. PubMed ID: 15728574
[TBL] [Abstract][Full Text] [Related]
12. TSC-insensitive Rheb mutations induce oncogenic transformation through a combination of constitutively active mTORC1 signalling and proteome remodelling.
Xie J; De Poi SP; Humphrey SJ; Hein LK; Bruning JB; Pan W; Selth LA; Sargeant TJ; Proud CG
Cell Mol Life Sci; 2021 Apr; 78(8):4035-4052. PubMed ID: 33834258
[TBL] [Abstract][Full Text] [Related]
13. TSC2: filling the GAP in the mTOR signaling pathway.
Li Y; Corradetti MN; Inoki K; Guan KL
Trends Biochem Sci; 2004 Jan; 29(1):32-8. PubMed ID: 14729330
[TBL] [Abstract][Full Text] [Related]
14. The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis.
Kang YJ; Lu MK; Guan KL
Cell Death Differ; 2011 Jan; 18(1):133-44. PubMed ID: 20616807
[TBL] [Abstract][Full Text] [Related]
15. Design of negative-regulating proteins of Rheb/mTORC1 with much-reduced sizes of the tuberous sclerosis protein complex.
Fu W; Wu G
Protein Sci; 2023 Aug; 32(8):e4731. PubMed ID: 37462942
[TBL] [Abstract][Full Text] [Related]
16. Activation of Rheb, but not of mTORC1, impairs spine synapse morphogenesis in tuberous sclerosis complex.
Yasuda S; Sugiura H; Katsurabayashi S; Shimada T; Tanaka H; Takasaki K; Iwasaki K; Kobayashi T; Hino O; Yamagata K
Sci Rep; 2014 Jun; 4():5155. PubMed ID: 24889507
[TBL] [Abstract][Full Text] [Related]
17. Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis.
Neuman NA; Henske EP
EMBO Mol Med; 2011 Apr; 3(4):189-200. PubMed ID: 21412983
[TBL] [Abstract][Full Text] [Related]
18. The TSC1-TSC2 complex: a molecular switchboard controlling cell growth.
Huang J; Manning BD
Biochem J; 2008 Jun; 412(2):179-90. PubMed ID: 18466115
[TBL] [Abstract][Full Text] [Related]
19. Redox regulates mammalian target of rapamycin complex 1 (mTORC1) activity by modulating the TSC1/TSC2-Rheb GTPase pathway.
Yoshida S; Hong S; Suzuki T; Nada S; Mannan AM; Wang J; Okada M; Guan KL; Inoki K
J Biol Chem; 2011 Sep; 286(37):32651-60. PubMed ID: 21784859
[TBL] [Abstract][Full Text] [Related]
20. VPS34 regulates TSC1/TSC2 heterodimer to mediate RheB and mTORC1/S6K1 activation and cellular transformation.
Mohan N; Shen Y; Dokmanovic M; Endo Y; Hirsch DS; Wu WJ
Oncotarget; 2016 Aug; 7(32):52239-52254. PubMed ID: 27409169
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
