BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

228 related articles for article (PubMed ID: 33454015)

  • 1. Polymerase γ efficiently replicates through many natural template barriers but stalls at the HSP1 quadruplex.
    Sullivan ED; Longley MJ; Copeland WC
    J Biol Chem; 2020 Dec; 295(51):17802-17815. PubMed ID: 33454015
    [TBL] [Abstract][Full Text] [Related]  

  • 2. DNA sequences proximal to human mitochondrial DNA deletion breakpoints prevalent in human disease form G-quadruplexes, a class of DNA structures inefficiently unwound by the mitochondrial replicative Twinkle helicase.
    Bharti SK; Sommers JA; Zhou J; Kaplan DL; Spelbrink JN; Mergny JL; Brosh RM
    J Biol Chem; 2014 Oct; 289(43):29975-93. PubMed ID: 25193669
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Oxidative DNA damage stalls the human mitochondrial replisome.
    Stojkovič G; Makarova AV; Wanrooij PH; Forslund J; Burgers PM; Wanrooij S
    Sci Rep; 2016 Jul; 6():28942. PubMed ID: 27364318
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Consequences of compromised mitochondrial genome integrity.
    Gustafson MA; Sullivan ED; Copeland WC
    DNA Repair (Amst); 2020 Sep; 93():102916. PubMed ID: 33087282
    [TBL] [Abstract][Full Text] [Related]  

  • 5. In vivo occupancy of mitochondrial single-stranded DNA binding protein supports the strand displacement mode of DNA replication.
    Miralles Fusté J; Shi Y; Wanrooij S; Zhu X; Jemt E; Persson Ö; Sabouri N; Gustafsson CM; Falkenberg M
    PLoS Genet; 2014 Dec; 10(12):e1004832. PubMed ID: 25474639
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Enhanced mitochondrial G-quadruplex formation impedes replication fork progression leading to mtDNA loss in human cells.
    Doimo M; Chaudhari N; Abrahamsson S; L'Hôte V; Nguyen TVH; Berner A; Ndi M; Abrahamsson A; Das RN; Aasumets K; Goffart S; Pohjoismäki JLO; López MD; Chorell E; Wanrooij S
    Nucleic Acids Res; 2023 Aug; 51(14):7392-7408. PubMed ID: 37351621
    [TBL] [Abstract][Full Text] [Related]  

  • 7. MMS exposure promotes increased MtDNA mutagenesis in the presence of replication-defective disease-associated DNA polymerase γ variants.
    Stumpf JD; Copeland WC
    PLoS Genet; 2014 Oct; 10(10):e1004748. PubMed ID: 25340760
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Ultrasensitive deletion detection links mitochondrial DNA replication, disease, and aging.
    Lujan SA; Longley MJ; Humble MH; Lavender CA; Burkholder A; Blakely EL; Alston CL; Gorman GS; Turnbull DM; McFarland R; Taylor RW; Kunkel TA; Copeland WC
    Genome Biol; 2020 Sep; 21(1):248. PubMed ID: 32943091
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Human mitochondrial DNA replication machinery and disease.
    Young MJ; Copeland WC
    Curr Opin Genet Dev; 2016 Jun; 38():52-62. PubMed ID: 27065468
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Complementary roles of Pif1 helicase and single stranded DNA binding proteins in stimulating DNA replication through G-quadruplexes.
    Sparks MA; Singh SP; Burgers PM; Galletto R
    Nucleic Acids Res; 2019 Sep; 47(16):8595-8605. PubMed ID: 31340040
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Mitochondrial genetic variation is enriched in G-quadruplex regions that stall DNA synthesis in vitro.
    Butler TJ; Estep KN; Sommers JA; Maul RW; Moore AZ; Bandinelli S; Cucca F; Tuke MA; Wood AR; Bharti SK; Bogenhagen DF; Yakubovskaya E; Garcia-Diaz M; Guilliam TA; Byrd AK; Raney KD; Doherty AJ; Ferrucci L; Schlessinger D; Ding J; Brosh RM
    Hum Mol Genet; 2020 May; 29(8):1292-1309. PubMed ID: 32191790
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Characterization of G4 DNA formation in mitochondrial DNA and their potential role in mitochondrial genome instability.
    Dahal S; Siddiqua H; Katapadi VK; Iyer D; Raghavan SC
    FEBS J; 2022 Jan; 289(1):163-182. PubMed ID: 34228888
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Mechanisms and pathologies of human mitochondrial DNA replication and deletion formation.
    Bernardino Gomes TM; Vincent AE; Menger KE; Stewart JB; Nicholls TJ
    Biochem J; 2024 Jun; 481(11):683-715. PubMed ID: 38804971
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Defects in mitochondrial DNA replication and human disease.
    Copeland WC
    Crit Rev Biochem Mol Biol; 2012; 47(1):64-74. PubMed ID: 22176657
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synergistic Effects of the
    DeBalsi KL; Longley MJ; Hoff KE; Copeland WC
    J Biol Chem; 2017 Mar; 292(10):4198-4209. PubMed ID: 28154168
    [TBL] [Abstract][Full Text] [Related]  

  • 16. In Vitro Analysis of mtDNA Replication.
    Uhler JP; Falkenberg M
    Methods Mol Biol; 2021; 2192():1-20. PubMed ID: 33230761
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Reduced stimulation of recombinant DNA polymerase γ and mitochondrial DNA (mtDNA) helicase by variants of mitochondrial single-stranded DNA-binding protein (mtSSB) correlates with defects in mtDNA replication in animal cells.
    Oliveira MT; Kaguni LS
    J Biol Chem; 2011 Nov; 286(47):40649-58. PubMed ID: 21953457
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The mitochondrial DNA polymerase gamma degrades linear DNA fragments precluding the formation of deletions.
    Nissanka N; Bacman SR; Plastini MJ; Moraes CT
    Nat Commun; 2018 Jun; 9(1):2491. PubMed ID: 29950568
    [TBL] [Abstract][Full Text] [Related]  

  • 19. RAD51C/XRCC3 Facilitates Mitochondrial DNA Replication and Maintains Integrity of the Mitochondrial Genome.
    Mishra A; Saxena S; Kaushal A; Nagaraju G
    Mol Cell Biol; 2018 Feb; 38(3):. PubMed ID: 29158291
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Depletion of mtDNA: syndromes and genes.
    Alberio S; Mineri R; Tiranti V; Zeviani M
    Mitochondrion; 2007; 7(1-2):6-12. PubMed ID: 17280874
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.