BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

247 related articles for article (PubMed ID: 33468664)

  • 1. Mdm2 phosphorylation by Akt regulates the p53 response to oxidative stress to promote cell proliferation and tumorigenesis.
    Chibaya L; Karim B; Zhang H; Jones SN
    Proc Natl Acad Sci U S A; 2021 Jan; 118(4):. PubMed ID: 33468664
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Phosphorylation of the Mdm2 oncoprotein by the c-Abl tyrosine kinase regulates p53 tumor suppression and the radiosensitivity of mice.
    Carr MI; Roderick JE; Zhang H; Woda BA; Kelliher MA; Jones SN
    Proc Natl Acad Sci U S A; 2016 Dec; 113(52):15024-15029. PubMed ID: 27956626
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Mdm2 Phosphorylation Regulates Its Stability and Has Contrasting Effects on Oncogene and Radiation-Induced Tumorigenesis.
    Carr MI; Roderick JE; Gannon HS; Kelliher MA; Jones SN
    Cell Rep; 2016 Sep; 16(10):2618-2629. PubMed ID: 27568562
    [TBL] [Abstract][Full Text] [Related]  

  • 4. p53 stabilization in response to DNA damage requires Akt/PKB and DNA-PK.
    Boehme KA; Kulikov R; Blattner C
    Proc Natl Acad Sci U S A; 2008 Jun; 105(22):7785-90. PubMed ID: 18505846
    [TBL] [Abstract][Full Text] [Related]  

  • 5. SPARC functions as an anti-stress factor by inactivating p53 through Akt-mediated MDM2 phosphorylation to promote melanoma cell survival.
    Fenouille N; Puissant A; Tichet M; Zimniak G; Abbe P; Mallavialle A; Rocchi S; Ortonne JP; Deckert M; Ballotti R; Tartare-Deckert S
    Oncogene; 2011 Dec; 30(49):4887-900. PubMed ID: 21685937
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Cooperation between p21 and Akt is required for p53-dependent cellular senescence.
    Kim YY; Jee HJ; Um JH; Kim YM; Bae SS; Yun J
    Aging Cell; 2017 Oct; 16(5):1094-1103. PubMed ID: 28691365
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Ret finger protein 2 enhances ionizing radiation-induced apoptosis via degradation of AKT and MDM2.
    Joo HM; Kim JY; Jeong JB; Seong KM; Nam SY; Yang KH; Kim CS; Kim HS; Jeong M; An S; Jin YW
    Eur J Cell Biol; 2011 May; 90(5):420-31. PubMed ID: 21333377
    [TBL] [Abstract][Full Text] [Related]  

  • 8. RBM38 plays a tumor-suppressor role via stabilizing the p53-mdm2 loop function in hepatocellular carcinoma.
    Ye J; Liang R; Bai T; Lin Y; Mai R; Wei M; Ye X; Li L; Wu F
    J Exp Clin Cancer Res; 2018 Sep; 37(1):212. PubMed ID: 30176896
    [TBL] [Abstract][Full Text] [Related]  

  • 9. ATM phosphorylation of Mdm2 Ser394 regulates the amplitude and duration of the DNA damage response in mice.
    Gannon HS; Woda BA; Jones SN
    Cancer Cell; 2012 May; 21(5):668-679. PubMed ID: 22624716
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Small Molecule Inhibition of MDM2-p53 Interaction Augments Radiation Response in Human Tumors.
    Werner LR; Huang S; Francis DM; Armstrong EA; Ma F; Li C; Iyer G; Canon J; Harari PM
    Mol Cancer Ther; 2015 Sep; 14(9):1994-2003. PubMed ID: 26162687
    [TBL] [Abstract][Full Text] [Related]  

  • 11. LRRK2 interacts with ATM and regulates Mdm2-p53 cell proliferation axis in response to genotoxic stress.
    Chen Z; Cao Z; Zhang W; Gu M; Zhou ZD; Li B; Li J; Tan EK; Zeng L
    Hum Mol Genet; 2017 Nov; 26(22):4494-4505. PubMed ID: 28973420
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The p53-Mdm2 feedback loop protects against DNA damage by inhibiting p53 activity but is dispensable for p53 stability, development, and longevity.
    Pant V; Xiong S; Jackson JG; Post SM; Abbas HA; Quintás-Cardama A; Hamir AN; Lozano G
    Genes Dev; 2013 Sep; 27(17):1857-67. PubMed ID: 23973961
    [TBL] [Abstract][Full Text] [Related]  

  • 13. ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage.
    Maya R; Balass M; Kim ST; Shkedy D; Leal JF; Shifman O; Moas M; Buschmann T; Ronai Z; Shiloh Y; Kastan MB; Katzir E; Oren M
    Genes Dev; 2001 May; 15(9):1067-77. PubMed ID: 11331603
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Hepatitis C virus core protein overcomes H2O2-induced apoptosis by downregulating p14 expression via DNA methylation.
    Seo YL; Heo S; Jang KL
    J Gen Virol; 2015 Apr; 96(Pt 4):822-832. PubMed ID: 25535325
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Akt enhances Mdm2-mediated ubiquitination and degradation of p53.
    Ogawara Y; Kishishita S; Obata T; Isazawa Y; Suzuki T; Tanaka K; Masuyama N; Gotoh Y
    J Biol Chem; 2002 Jun; 277(24):21843-50. PubMed ID: 11923280
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage.
    Khosravi R; Maya R; Gottlieb T; Oren M; Shiloh Y; Shkedy D
    Proc Natl Acad Sci U S A; 1999 Dec; 96(26):14973-7. PubMed ID: 10611322
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The role of AKT/mTOR pathway in stress response to UV-irradiation: implication in skin carcinogenesis by regulation of apoptosis, autophagy and senescence.
    Strozyk E; Kulms D
    Int J Mol Sci; 2013 Jul; 14(8):15260-85. PubMed ID: 23887651
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Analysis of the K-ras and p53 pathways in X-ray-induced lung tumors in the rat.
    Belinsky SA; Middleton SK; Picksley SM; Hahn FF; Nikula KJ
    Radiat Res; 1996 Apr; 145(4):449-56. PubMed ID: 8600505
    [TBL] [Abstract][Full Text] [Related]  

  • 19. AKT regulates NPM dependent ARF localization and p53mut stability in tumors.
    Hamilton G; Abraham AG; Morton J; Sampson O; Pefani DE; Khoronenkova S; Grawenda A; Papaspyropoulos A; Jamieson N; McKay C; Sansom O; Dianov GL; O'Neill E
    Oncotarget; 2014 Aug; 5(15):6142-67. PubMed ID: 25071014
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Activation of AKT and nuclear accumulation of wild type TP53 and MDM2 in anal squamous cell carcinoma.
    Patel H; Polanco-Echeverry G; Segditsas S; Volikos E; McCart A; Lai C; Guenther T; Zaitoun A; Sieber O; Ilyas M; Northover J; Silver A
    Int J Cancer; 2007 Dec; 121(12):2668-73. PubMed ID: 17721920
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.