These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

276 related articles for article (PubMed ID: 33479693)

  • 21. Synergistic inhibition of Aβ production by combinations of γ-secretase modulators.
    Robertson AS; Iben LG; Wei C; Meredith JE; Drexler DM; Banks M; Vite GD; Olson RE; Thompson LA; Albright CF; Ahlijanian MK; Toyn JH
    Eur J Pharmacol; 2017 Oct; 812():104-112. PubMed ID: 28690193
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Targeting Amyloidogenic Processing of APP in Alzheimer's Disease.
    Zhao J; Liu X; Xia W; Zhang Y; Wang C
    Front Mol Neurosci; 2020; 13():137. PubMed ID: 32848600
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Gamma-secretase modulators: a promising route for the treatment of Alzheimer's disease.
    Nordvall G; Lundkvist J; Sandin J
    Front Mol Neurosci; 2023; 16():1279740. PubMed ID: 37908487
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Advances in gamma-secretase modulation.
    Pissarnitski D
    Curr Opin Drug Discov Devel; 2007 Jul; 10(4):392-402. PubMed ID: 17659480
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects.
    Toyn JH; Boy KM; Raybon J; Meredith JE; Robertson AS; Guss V; Hoque N; Sweeney F; Zhuo X; Clarke W; Snow K; Denton RR; Zuev D; Thompson LA; Morrison J; Grace J; Berisha F; Furlong M; Wang JS; Lentz KA; Padmanabha R; Cook L; Wei C; Drexler DM; Macor JE; Albright CF; Gasior M; Olson RE; Hong Q; Soares HD; AbuTarif M; Ahlijanian MK
    J Pharmacol Exp Ther; 2016 Jul; 358(1):125-37. PubMed ID: 27189974
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Independent generation of Abeta42 and Abeta38 peptide species by gamma-secretase.
    Czirr E; Cottrell BA; Leuchtenberger S; Kukar T; Ladd TB; Esselmann H; Paul S; Schubenel R; Torpey JW; Pietrzik CU; Golde TE; Wiltfang J; Baumann K; Koo EH; Weggen S
    J Biol Chem; 2008 Jun; 283(25):17049-54. PubMed ID: 18426795
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Turning the tide on Alzheimer's disease: modulation of γ-secretase.
    Luo JE; Li YM
    Cell Biosci; 2022 Jan; 12(1):2. PubMed ID: 34983641
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Combining an amyloid-beta (Aβ) cleaving enzyme inhibitor with a γ-secretase modulator results in an additive reduction of Aβ production.
    Strömberg K; Eketjäll S; Georgievska B; Tunblad K; Eliason K; Olsson F; Radesäter AC; Klintenberg R; Arvidsson PI; von Berg S; Fälting J; Cowburn RF; Dabrowski M
    FEBS J; 2015 Jan; 282(1):65-73. PubMed ID: 25303711
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Modulation of gamma-secretase for the treatment of Alzheimer's disease.
    Tate B; McKee TD; Loureiro RM; Dumin JA; Xia W; Pojasek K; Austin WF; Fuller NO; Hubbs JL; Shen R; Jonker J; Ives J; Bronk BS
    Int J Alzheimers Dis; 2012; 2012():210756. PubMed ID: 23320246
    [TBL] [Abstract][Full Text] [Related]  

  • 30. CTF1-51, a truncated carboxyl-terminal fragment of amyloid precursor protein, suppresses the effects of Aβ42-lowering γ-secretase modulators.
    Watahiki H; Yagishita S; Futai E; Ishiura S
    Neurosci Lett; 2012 Sep; 526(2):96-9. PubMed ID: 22940081
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Presenilin-1 but not amyloid precursor protein mutations present in mouse models of Alzheimer's disease attenuate the response of cultured cells to γ-secretase modulators regardless of their potency and structure.
    Hahn S; Brüning T; Ness J; Czirr E; Baches S; Gijsen H; Korth C; Pietrzik CU; Bulic B; Weggen S
    J Neurochem; 2011 Feb; 116(3):385-95. PubMed ID: 21091478
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Highlights in BACE1 Inhibitors for Alzheimer's Disease Treatment.
    Coimbra JRM; Marques DFF; Baptista SJ; Pereira CMF; Moreira PI; Dinis TCP; Santos AE; Salvador JAR
    Front Chem; 2018; 6():178. PubMed ID: 29881722
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Interacting with γ-secretase for treating Alzheimer's disease: from inhibition to modulation.
    Panza F; Frisardi V; Solfrizzi V; Imbimbo BP; Logroscino G; Santamato A; Greco A; Seripa D; Pilotto A
    Curr Med Chem; 2011; 18(35):5430-47. PubMed ID: 22087836
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Identification of new Presenilin-1 phosphosites: implication for γ-secretase activity and Aβ production.
    Matz A; Halamoda-Kenzaoui B; Hamelin R; Mosser S; Alattia JR; Dimitrov M; Moniatte M; Fraering PC
    J Neurochem; 2015 May; 133(3):409-21. PubMed ID: 25458374
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Analyzing Amyloid-β Peptide Modulation Profiles and Binding Sites of γ-Secretase Modulators.
    Trambauer J; Fukumori A; Kretner B; Steiner H
    Methods Enzymol; 2017; 584():157-183. PubMed ID: 28065262
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Novel γ-secretase modulators: a review of patents from 2008 to 2010.
    Pettersson M; Kauffman GW; am Ende CW; Patel NC; Stiff C; Tran TP; Johnson DS
    Expert Opin Ther Pat; 2011 Feb; 21(2):205-26. PubMed ID: 21231889
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Scope of β-Secretase (BACE1)-Targeted Therapy in Alzheimer's Disease: Emphasizing the Flavonoid Based Natural Scaffold for BACE1 Inhibition.
    Das S; Sengupta S; Chakraborty S
    ACS Chem Neurosci; 2020 Nov; 11(21):3510-3522. PubMed ID: 33073981
    [TBL] [Abstract][Full Text] [Related]  

  • 38. γ-secretase inhibitors and modulators for the treatment of Alzheimer's disease: disappointments and hopes.
    Imbimbo BP; Giardina GA
    Curr Top Med Chem; 2011; 11(12):1555-70. PubMed ID: 21510832
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Disease-modifying therapies in Alzheimer's disease: how far have we come?
    Hüll M; Berger M; Heneka M
    Drugs; 2006; 66(16):2075-93. PubMed ID: 17112302
    [TBL] [Abstract][Full Text] [Related]  

  • 40. A γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP.
    Weissmiller AM; Natera-Naranjo O; Reyna SM; Pearn ML; Zhao X; Nguyen P; Cheng S; Goldstein LS; Tanzi RE; Wagner SL; Mobley WC; Wu C
    PLoS One; 2015; 10(2):e0118379. PubMed ID: 25710492
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 14.