216 related articles for article (PubMed ID: 33487592)
1. Targeting cancer stem cells with a pan-BCL-2 inhibitor in preclinical and clinical settings in patients with gastroesophageal carcinoma.
Song S; Chen Q; Li Y; Lei G; Scott A; Huo L; Li CY; Estrella JS; Correa A; Pizzi MP; Ma L; Jin J; Liu B; Wang Y; Xiao L; Hofstetter WL; Lee JH; Weston B; Bhutani M; Shanbhag N; Johnson RL; Gan B; Wei S; Ajani JA
Gut; 2021 Dec; 70(12):2238-2248. PubMed ID: 33487592
[TBL] [Abstract][Full Text] [Related]
2. The pan-Bcl2 Inhibitor AT101 Activates the Intrinsic Apoptotic Pathway and Causes DNA Damage in Acute Myeloid Leukemia Stem-Like Cells.
Zhang L; Zhou Y; Chen K; Shi P; Li Y; Deng M; Jiang Z; Wang X; Li P; Xu B
Target Oncol; 2017 Oct; 12(5):677-687. PubMed ID: 28710745
[TBL] [Abstract][Full Text] [Related]
3. Inhibition of Mcl-1 with the pan-Bcl-2 family inhibitor (-)BI97D6 overcomes ABT-737 resistance in acute myeloid leukemia.
Pan R; Ruvolo VR; Wei J; Konopleva M; Reed JC; Pellecchia M; Andreeff M; Ruvolo PP
Blood; 2015 Jul; 126(3):363-72. PubMed ID: 26045609
[TBL] [Abstract][Full Text] [Related]
4. Proapoptotic protein Smac mediates apoptosis in cisplatin-resistant ovarian cancer cells when treated with the anti-tumor agent AT101.
Hu W; Wang F; Tang J; Liu X; Yuan Z; Nie C; Wei Y
J Biol Chem; 2012 Jan; 287(1):68-80. PubMed ID: 22052903
[TBL] [Abstract][Full Text] [Related]
5. AT101 exerts a synergetic efficacy in gastric cancer patients with 5-FU based treatment through promoting apoptosis and autophagy.
Wei X; Duan W; Li Y; Zhang S; Xin X; Sun L; Gao M; Li Q; Wang D
Oncotarget; 2016 Jun; 7(23):34430-41. PubMed ID: 27144437
[TBL] [Abstract][Full Text] [Related]
6. Sabutoclax, pan-active BCL-2 protein family antagonist, overcomes drug resistance and eliminates cancer stem cells in breast cancer.
Hu Y; Yagüe E; Zhao J; Wang L; Bai J; Yang Q; Pan T; Zhao H; Liu J; Zhang J
Cancer Lett; 2018 Jun; 423():47-59. PubMed ID: 29496539
[TBL] [Abstract][Full Text] [Related]
7. AT-101, a pan-Bcl-2 inhibitor, leads to radiosensitization of non-small cell lung cancer.
Moretti L; Li B; Kim KW; Chen H; Lu B
J Thorac Oncol; 2010 May; 5(5):680-7. PubMed ID: 20354451
[TBL] [Abstract][Full Text] [Related]
8. Targeting anti-apoptotic Bcl-2 by AT-101 to increase radiation efficacy: data from in vitro and clinical pharmacokinetic studies in head and neck cancer.
Zerp SF; Stoter TR; Hoebers FJ; van den Brekel MW; Dubbelman R; Kuipers GK; Lafleur MV; Slotman BJ; Verheij M
Radiat Oncol; 2015 Jul; 10():158. PubMed ID: 26223311
[TBL] [Abstract][Full Text] [Related]
9. In vivo evaluation of AT-101 (R-(-)-gossypol acetic acid) in androgen-independent growth of VCaP prostate cancer cells in combination with surgical castration.
Loberg RD; McGregor N; Ying C; Sargent E; Pienta KJ
Neoplasia; 2007 Dec; 9(12):1030-7. PubMed ID: 18084610
[TBL] [Abstract][Full Text] [Related]
10. Induction of apoptosis and antitumor effects of a small molecule inhibitor of Bcl-2 and Bcl-xl, gossypol acetate, in multiple myeloma in vitro and in vivo.
Lin J; Wu Y; Yang D; Zhao Y
Oncol Rep; 2013 Aug; 30(2):731-8. PubMed ID: 23708869
[TBL] [Abstract][Full Text] [Related]
11. Targeting Bcl-2 family members with the BH3 mimetic AT-101 markedly enhances the therapeutic effects of chemotherapeutic agents in in vitro and in vivo models of B-cell lymphoma.
Paoluzzi L; Gonen M; Gardner JR; Mastrella J; Yang D; Holmlund J; Sorensen M; Leopold L; Manova K; Marcucci G; Heaney ML; O'Connor OA
Blood; 2008 Jun; 111(11):5350-8. PubMed ID: 18292288
[TBL] [Abstract][Full Text] [Related]
12. Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.
Meng Y; Tang W; Dai Y; Wu X; Liu M; Ji Q; Ji M; Pienta K; Lawrence T; Xu L
Mol Cancer Ther; 2008 Jul; 7(7):2192-202. PubMed ID: 18645028
[TBL] [Abstract][Full Text] [Related]
13. AT101-Loaded Cubosomes as an Alternative for Improved Glioblastoma Therapy.
Flak DK; Adamski V; Nowaczyk G; Szutkowski K; Synowitz M; Jurga S; Held-Feindt J
Int J Nanomedicine; 2020; 15():7415-7431. PubMed ID: 33116479
[TBL] [Abstract][Full Text] [Related]
14. ApoG2 as the most potent gossypol derivatives inhibits cell growth and induces apoptosis on gastric cancer cells.
Xin J; Zhan YH; Xia LM; Zhu HW; Nie YZ; Liang JM; Tian J
Biomed Pharmacother; 2013 Feb; 67(1):88-95. PubMed ID: 23201009
[TBL] [Abstract][Full Text] [Related]
15. ABT-263 induces apoptosis and synergizes with chemotherapy by targeting stemness pathways in esophageal cancer.
Chen Q; Song S; Wei S; Liu B; Honjo S; Scott A; Jin J; Ma L; Zhu H; Skinner HD; Johnson RL; Ajani JA
Oncotarget; 2015 Sep; 6(28):25883-96. PubMed ID: 26317542
[TBL] [Abstract][Full Text] [Related]
16. Synergistic antitumoral activity and induction of apoptosis by novel pan Bcl-2 proteins inhibitor apogossypolone with adriamycin in human hepatocellular carcinoma.
Mi JX; Wang GF; Wang HB; Sun XQ; Ni XY; Zhang XW; Tang JM; Yang DJ
Acta Pharmacol Sin; 2008 Dec; 29(12):1467-77. PubMed ID: 19026166
[TBL] [Abstract][Full Text] [Related]
17. AT-101 enhances gefitinib sensitivity in non-small cell lung cancer with EGFR T790M mutations.
Zhao R; Zhou S; Xia B; Zhang CY; Hai P; Zhe H; Wang YY
BMC Cancer; 2016 Jul; 16():491. PubMed ID: 27431492
[TBL] [Abstract][Full Text] [Related]
18. AT-101, a small molecule inhibitor of anti-apoptotic Bcl-2 family members, activates the SAPK/JNK pathway and enhances radiation-induced apoptosis.
Zerp SF; Stoter R; Kuipers G; Yang D; Lippman ME; van Blitterswijk WJ; Bartelink H; Rooswinkel R; Lafleur V; Verheij M
Radiat Oncol; 2009 Oct; 4():47. PubMed ID: 19852810
[TBL] [Abstract][Full Text] [Related]
19. BNIP3 regulates AT101 [(-)-gossypol] induced death in malignant peripheral nerve sheath tumor cells.
Kaza N; Kohli L; Graham CD; Klocke BJ; Carroll SL; Roth KA
PLoS One; 2014; 9(5):e96733. PubMed ID: 24824755
[TBL] [Abstract][Full Text] [Related]
20. Glucocorticoid sensitisation in Mixed Lineage Leukaemia-rearranged acute lymphoblastic leukaemia by the pan-BCL-2 family inhibitors gossypol and AT-101.
Spijkers-Hagelstein JA; Schneider P; Pinhanços SM; Garrido Castro P; Pieters R; Stam RW
Eur J Cancer; 2014 Jun; 50(9):1665-74. PubMed ID: 24703900
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]