BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

410 related articles for article (PubMed ID: 33492644)

  • 1. Inhibition of p38 Mitogen-Activated Protein Kinase Ameliorates HAP40 Depletion-Induced Toxicity and Proteasomal Defect in Huntington's Disease Model.
    Huang ZN; Chen JM; Huang LC; Fang YH; Her LS
    Mol Neurobiol; 2021 Jun; 58(6):2704-2723. PubMed ID: 33492644
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The Ubiquitin Receptor ADRM1 Modulates HAP40-Induced Proteasome Activity.
    Huang ZN; Her LS
    Mol Neurobiol; 2017 Nov; 54(9):7382-7400. PubMed ID: 27815841
    [TBL] [Abstract][Full Text] [Related]  

  • 3. HAP40 modulates mutant Huntingtin aggregation and toxicity in Huntington's disease mice.
    Chen L; Qin Y; Guo T; Zhu W; Lin J; Xing T; Duan X; Zhang Y; Ruan E; Li X; Yin P; Li S; Li XJ; Yang S
    Cell Death Dis; 2024 May; 15(5):337. PubMed ID: 38744826
    [TBL] [Abstract][Full Text] [Related]  

  • 4. HAP40 is a conserved central regulator of Huntingtin and a potential modulator of Huntington's disease pathogenesis.
    Xu S; Li G; Ye X; Chen D; Chen Z; Xu Z; Daniele M; Tambone S; Ceccacci A; Tomei L; Ye L; Yu Y; Solbach A; Farmer SM; Stimming EF; McAllister G; Marchionini DM; Zhang S
    PLoS Genet; 2022 Jul; 18(7):e1010302. PubMed ID: 35853002
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Herp Promotes Degradation of Mutant Huntingtin: Involvement of the Proteasome and Molecular Chaperones.
    Luo H; Cao L; Liang X; Du A; Peng T; Li H
    Mol Neurobiol; 2018 Oct; 55(10):7652-7668. PubMed ID: 29430620
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Pathological polyQ expansion does not alter the conformation of the Huntingtin-HAP40 complex.
    Huang B; Guo Q; Niedermeier ML; Cheng J; Engler T; Maurer M; Pautsch A; Baumeister W; Stengel F; Kochanek S; Fernández-Busnadiego R
    Structure; 2021 Aug; 29(8):804-809.e5. PubMed ID: 33909994
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Ubiquitin-proteasome system alterations in a striatal cell model of Huntington's disease.
    Hunter JM; Lesort M; Johnson GV
    J Neurosci Res; 2007 Jun; 85(8):1774-88. PubMed ID: 17455294
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Huntingtin and Its Partner Huntingtin-Associated Protein 40: Structural and Functional Considerations in Health and Disease.
    Seefelder M; Klein FAC; Landwehrmeyer B; Fernández-Busnadiego R; Kochanek S
    J Huntingtons Dis; 2022; 11(3):227-242. PubMed ID: 35871360
    [TBL] [Abstract][Full Text] [Related]  

  • 9. P38 MAPK is involved in enhanced NMDA receptor-dependent excitotoxicity in YAC transgenic mouse model of Huntington disease.
    Fan J; Gladding CM; Wang L; Zhang LY; Kaufman AM; Milnerwood AJ; Raymond LA
    Neurobiol Dis; 2012 Mar; 45(3):999-1009. PubMed ID: 22198502
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Atypical ubiquitination by E3 ligase WWP1 inhibits the proteasome-mediated degradation of mutant huntingtin.
    Lin L; Jin Z; Tan H; Xu Q; Peng T; Li H
    Brain Res; 2016 Jul; 1643():103-12. PubMed ID: 27107943
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Striatal Mutant Huntingtin Protein Levels Decline with Age in Homozygous Huntington's Disease Knock-In Mouse Models.
    Franich NR; Basso M; André EA; Ochaba J; Kumar A; Thein S; Fote G; Kachemov M; Lau AL; Yeung SY; Osmand A; Zeitlin SO; Ratan RR; Thompson LM; Steffan JS
    J Huntingtons Dis; 2018; 7(2):137-150. PubMed ID: 29843246
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Deletion of the huntingtin polyglutamine stretch enhances neuronal autophagy and longevity in mice.
    Zheng S; Clabough EB; Sarkar S; Futter M; Rubinsztein DC; Zeitlin SO
    PLoS Genet; 2010 Feb; 6(2):e1000838. PubMed ID: 20140187
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Pramipexole reduces soluble mutant huntingtin and protects striatal neurons through dopamine D3 receptors in a genetic model of Huntington's disease.
    Luis-Ravelo D; Estévez-Silva H; Barroso-Chinea P; Afonso-Oramas D; Salas-Hernández J; Rodríguez-Núñez J; Acevedo-Arozena A; Marcellino D; González-Hernández T
    Exp Neurol; 2018 Jan; 299(Pt A):137-147. PubMed ID: 29056363
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Full length mutant huntingtin is required for altered Ca2+ signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington's disease.
    Zhang H; Li Q; Graham RK; Slow E; Hayden MR; Bezprozvanny I
    Neurobiol Dis; 2008 Jul; 31(1):80-8. PubMed ID: 18502655
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The ubiquitin conjugating enzyme Ube2W regulates solubility of the Huntington's disease protein, huntingtin.
    Wang B; Zeng L; Merillat SA; Fischer S; Ochaba J; Thompson LM; Barmada SJ; Scaglione KM; Paulson HL
    Neurobiol Dis; 2018 Jan; 109(Pt A):127-136. PubMed ID: 28986324
    [TBL] [Abstract][Full Text] [Related]  

  • 16. HAP40 protein levels are huntingtin-dependent and decrease in Huntington disease.
    Huang B; Seefelder M; Buck E; Engler T; Lindenberg KS; Klein F; Landwehrmeyer GB; Kochanek S
    Neurobiol Dis; 2021 Oct; 158():105476. PubMed ID: 34390835
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The Differential Profiling of Ubiquitin-Proteasome and Autophagy Systems in Different Tissues before the Onset of Huntington's Disease Models.
    Her LS; Lin JY; Fu MH; Chang YF; Li CL; Tang TY; Jhang YL; Chang CY; Shih MC; Cheng PH; Yang SH
    Brain Pathol; 2015 Jul; 25(4):481-90. PubMed ID: 25178567
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Depletion of p62 reduces nuclear inclusions and paradoxically ameliorates disease phenotypes in Huntington's model mice.
    Kurosawa M; Matsumoto G; Kino Y; Okuno M; Kurosawa-Yamada M; Washizu C; Taniguchi H; Nakaso K; Yanagawa T; Warabi E; Shimogori T; Sakurai T; Hattori N; Nukina N
    Hum Mol Genet; 2015 Feb; 24(4):1092-105. PubMed ID: 25305080
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Inhibiting the ubiquitin-proteasome system leads to preferential accumulation of toxic N-terminal mutant huntingtin fragments.
    Li X; Wang CE; Huang S; Xu X; Li XJ; Li H; Li S
    Hum Mol Genet; 2010 Jun; 19(12):2445-55. PubMed ID: 20354076
    [TBL] [Abstract][Full Text] [Related]  

  • 20. IKKβ slows Huntington's disease progression in R6/1 mice.
    Ochaba J; Fote G; Kachemov M; Thein S; Yeung SY; Lau AL; Hernandez S; Lim RG; Casale M; Neel MJ; Monuki ES; Reidling J; Housman DE; Thompson LM; Steffan JS
    Proc Natl Acad Sci U S A; 2019 May; 116(22):10952-10961. PubMed ID: 31088970
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 21.