These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

144 related articles for article (PubMed ID: 33497888)

  • 1. Discovery of 3-phenyl- and 3-N-piperidinyl-isothiazolo[4,3-b]pyridines as highly potent inhibitors of cyclin G-associated kinase.
    Martinez-Gualda B; Saul S; Froeyen M; Schols D; Herdewijn P; Einav S; De Jonghe S
    Eur J Med Chem; 2021 Mar; 213():113158. PubMed ID: 33497888
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structure-activity relationship study of the pyridine moiety of isothiazolo[4,3-b]pyridines as antiviral agents targeting cyclin G-associated kinase.
    Martinez-Gualda B; Pu SY; Froeyen M; Herdewijn P; Einav S; De Jonghe S
    Bioorg Med Chem; 2020 Jan; 28(1):115188. PubMed ID: 31757682
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Cyclin G-associated kinase (GAK) affinity and antiviral activity studies of a series of 3-C-substituted isothiazolo[4,3-b]pyridines.
    Wouters R; Pu SY; Froeyen M; Lescrinier E; Einav S; Herdewijn P; De Jonghe S
    Eur J Med Chem; 2019 Feb; 163():256-265. PubMed ID: 30529544
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Optimization of Isothiazolo[4,3- b]pyridine-Based Inhibitors of Cyclin G Associated Kinase (GAK) with Broad-Spectrum Antiviral Activity.
    Pu SY; Wouters R; Schor S; Rozenski J; Barouch-Bentov R; Prugar LI; O'Brien CM; Brannan JM; Dye JM; Herdewijn P; De Jonghe S; Einav S
    J Med Chem; 2018 Jul; 61(14):6178-6192. PubMed ID: 29953812
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Selective Inhibitors of Cyclin G Associated Kinase (GAK) as Anti-Hepatitis C Agents.
    Kovackova S; Chang L; Bekerman E; Neveu G; Barouch-Bentov R; Chaikuad A; Heroven C; Šála M; De Jonghe S; Knapp S; Einav S; Herdewijn P
    J Med Chem; 2015 Apr; 58(8):3393-410. PubMed ID: 25822739
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis and evaluation of isothiazolo[4,5-
    Ivanova Y; Spittaels S; Gao LJ; Schols D; Van Meervelt L; Froeyen M; Dehaen W; De Jonghe S
    Org Biomol Chem; 2024 Sep; 22(36):7373-7389. PubMed ID: 39171941
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A Scaffold-Hopping Strategy toward the Identification of Inhibitors of Cyclin G Associated Kinase.
    Wouters R; Tian J; Herdewijn P; De Jonghe S
    ChemMedChem; 2019 Jan; 14(2):237-254. PubMed ID: 30548533
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Targeting the Water Network in Cyclin G-Associated Kinase (GAK) with 4-Anilino-quin(az)oline Inhibitors.
    Asquith CRM; Tizzard GJ; Bennett JM; Wells CI; Elkins JM; Willson TM; Poso A; Laitinen T
    ChemMedChem; 2020 Jul; 15(13):1200-1215. PubMed ID: 32358915
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Design of a Cyclin G Associated Kinase (GAK)/Epidermal Growth Factor Receptor (EGFR) Inhibitor Set to Interrogate the Relationship of EGFR and GAK in Chordoma.
    Asquith CRM; Naegeli KM; East MP; Laitinen T; Havener TM; Wells CI; Johnson GL; Drewry DH; Zuercher WJ; Morris DC
    J Med Chem; 2019 May; 62(9):4772-4778. PubMed ID: 30973735
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects.
    Bekerman E; Neveu G; Shulla A; Brannan J; Pu SY; Wang S; Xiao F; Barouch-Bentov R; Bakken RR; Mateo R; Govero J; Nagamine CM; Diamond MS; De Jonghe S; Herdewijn P; Dye JM; Randall G; Einav S
    J Clin Invest; 2017 Apr; 127(4):1338-1352. PubMed ID: 28240606
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Identification and Optimization of 4-Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase.
    Asquith CRM; Laitinen T; Bennett JM; Godoi PH; East MP; Tizzard GJ; Graves LM; Johnson GL; Dornsife RE; Wells CI; Elkins JM; Willson TM; Zuercher WJ
    ChemMedChem; 2018 Jan; 13(1):48-66. PubMed ID: 29072804
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Discovery of a series of 1H-pyrrolo[2,3-b]pyridine compounds as potent TNIK inhibitors.
    Yang B; Wu Q; Huan X; Wang Y; Sun Y; Yang Y; Liu T; Wang X; Chen L; Xiong B; Zhao D; Miao Z; Chen D
    Bioorg Med Chem Lett; 2021 Feb; 33():127749. PubMed ID: 33340663
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis and Structure-Activity Relationships of 3,5-Disubstituted-pyrrolo[2,3- b]pyridines as Inhibitors of Adaptor-Associated Kinase 1 with Antiviral Activity.
    Verdonck S; Pu SY; Sorrell FJ; Elkins JM; Froeyen M; Gao LJ; Prugar LI; Dorosky DE; Brannan JM; Barouch-Bentov R; Knapp S; Dye JM; Herdewijn P; Einav S; De Jonghe S
    J Med Chem; 2019 Jun; 62(12):5810-5831. PubMed ID: 31136173
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Isothiazolo[4,3-
    Li J; Kovackova S; Pu S; Rozenski J; De Jonghe S; Einav S; Herdewijn P
    Medchemcomm; 2015 Sep; 6(9):1666-1672. PubMed ID: 26925208
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Design, Synthesis, and Biological Evaluation of Substituted 4,6-Dihydrospiro[[1,2,3]triazolo[4,5-
    Xu J; Xie X; Ye N; Zou J; Chen H; White MA; Shi PY; Zhou J
    J Med Chem; 2019 Sep; 62(17):7941-7960. PubMed ID: 31403780
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis and evaluation of 7-azaindole derivatives bearing benzocycloalkanone motifs as protein kinase inhibitors.
    Qhobosheane MA; Legoabe LJ; Josselin B; Bach S; Ruchaud S; Petzer JP; Beteck RM
    Bioorg Med Chem; 2020 Jun; 28(11):115468. PubMed ID: 32284225
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Potency switch between CHK1 and MK2: discovery of imidazo[1,2-a]pyrazine- and imidazo[1,2-c]pyrimidine-based kinase inhibitors.
    Meng Z; Ciavarri JP; McRiner A; Zhao Y; Zhao L; Reddy PA; Zhang X; Fischmann TO; Whitehurst C; Arshad Siddiqui M
    Bioorg Med Chem Lett; 2013 May; 23(10):2863-7. PubMed ID: 23587425
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Discovery and optimization of phthalazinone derivatives as a new class of potent dengue virus inhibitors.
    Lu D; Liu J; Zhang Y; Liu F; Zeng L; Peng R; Yang L; Ying H; Tang W; Chen W; Zuo J; Tong X; Liu T; Hu Y
    Eur J Med Chem; 2018 Feb; 145():328-337. PubMed ID: 29335200
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Back-Pocket Optimization of 2-Aminopyrimidine-Based Macrocycles Leads to Potent EPHA2/GAK Kinase Inhibitors.
    Gerninghaus J; Zhubi R; Krämer A; Karim M; Tran DHN; Joerger AC; Schreiber C; Berger LM; Berger BT; Ehret TAL; Elson L; Lenz C; Saxena K; Müller S; Einav S; Knapp S; Hanke T
    J Med Chem; 2024 Aug; 67(15):12534-12552. PubMed ID: 39028937
    [TBL] [Abstract][Full Text] [Related]  

  • 20. An integrated approach for discovery of highly potent and selective Mnk inhibitors: Screening, synthesis and SAR analysis.
    Teo T; Yang Y; Yu M; Basnet SK; Gillam T; Hou J; Schmid RM; Kumarasiri M; Diab S; Albrecht H; Sykes MJ; Wang S
    Eur J Med Chem; 2015 Oct; 103():539-50. PubMed ID: 26408454
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.