226 related articles for article (PubMed ID: 33506760)
1. Identification of ligand-specific G protein-coupled receptor states and prediction of downstream efficacy via data-driven modeling.
Fleetwood O; Carlsson J; Delemotte L
Elife; 2021 Jan; 10():. PubMed ID: 33506760
[TBL] [Abstract][Full Text] [Related]
2. Energy Landscapes Reveal Agonist Control of G Protein-Coupled Receptor Activation via Microswitches.
Fleetwood O; Matricon P; Carlsson J; Delemotte L
Biochemistry; 2020 Feb; 59(7):880-891. PubMed ID: 31999436
[TBL] [Abstract][Full Text] [Related]
3. Allosteric Effect of Nanobody Binding on Ligand-Specific Active States of the β2 Adrenergic Receptor.
Chen Y; Fleetwood O; Pérez-Conesa S; Delemotte L
J Chem Inf Model; 2021 Dec; 61(12):6024-6037. PubMed ID: 34780174
[TBL] [Abstract][Full Text] [Related]
4. Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation.
Staus DP; Strachan RT; Manglik A; Pani B; Kahsai AW; Kim TH; Wingler LM; Ahn S; Chatterjee A; Masoudi A; Kruse AC; Pardon E; Steyaert J; Weis WI; Prosser RS; Kobilka BK; Costa T; Lefkowitz RJ
Nature; 2016 Jul; 535(7612):448-52. PubMed ID: 27409812
[TBL] [Abstract][Full Text] [Related]
5. Determinants of Neutral Antagonism and Inverse Agonism in the β
Calderón JC; Ibrahim P; Gobbo D; Gervasio FL; Clark T
J Chem Inf Model; 2024 Mar; 64(6):2045-2057. PubMed ID: 38447156
[TBL] [Abstract][Full Text] [Related]
6. Molecular dynamics simulations of the effect of the G-protein and diffusible ligands on the β2-adrenergic receptor.
Goetz A; Lanig H; Gmeiner P; Clark T
J Mol Biol; 2011 Dec; 414(4):611-23. PubMed ID: 22037586
[TBL] [Abstract][Full Text] [Related]
7. Activation of the A2A adenosine G-protein-coupled receptor by conformational selection.
Ye L; Van Eps N; Zimmer M; Ernst OP; Prosser RS
Nature; 2016 May; 533(7602):265-8. PubMed ID: 27144352
[TBL] [Abstract][Full Text] [Related]
8. Allosteric coupling from G protein to the agonist-binding pocket in GPCRs.
DeVree BT; Mahoney JP; Vélez-Ruiz GA; Rasmussen SG; Kuszak AJ; Edwald E; Fung JJ; Manglik A; Masureel M; Du Y; Matt RA; Pardon E; Steyaert J; Kobilka BK; Sunahara RK
Nature; 2016 Jul; 535(7610):182-6. PubMed ID: 27362234
[TBL] [Abstract][Full Text] [Related]
9. Investigation of allosteric coupling in human β2-adrenergic receptor in the presence of intracellular loop 3.
Ozgur C; Doruker P; Akten ED
BMC Struct Biol; 2016 Jul; 16(1):9. PubMed ID: 27368374
[TBL] [Abstract][Full Text] [Related]
10. Simulations of biased agonists in the β(2) adrenergic receptor with accelerated molecular dynamics.
Tikhonova IG; Selvam B; Ivetac A; Wereszczynski J; McCammon JA
Biochemistry; 2013 Aug; 52(33):5593-603. PubMed ID: 23879802
[TBL] [Abstract][Full Text] [Related]
11. Functionally different agonists induce distinct conformations in the G protein coupling domain of the beta 2 adrenergic receptor.
Ghanouni P; Gryczynski Z; Steenhuis JJ; Lee TW; Farrens DL; Lakowicz JR; Kobilka BK
J Biol Chem; 2001 Jul; 276(27):24433-6. PubMed ID: 11320077
[TBL] [Abstract][Full Text] [Related]
12. A structural basis for how ligand binding site changes can allosterically regulate GPCR signaling and engender functional selectivity.
Sanchez-Soto M; Verma RK; Willette BKA; Gonye EC; Moore AM; Moritz AE; Boateng CA; Yano H; Free RB; Shi L; Sibley DR
Sci Signal; 2020 Feb; 13(617):. PubMed ID: 32019899
[TBL] [Abstract][Full Text] [Related]
13. GDP Release from the Open Conformation of Gα Requires Allosteric Signaling from the Agonist-Bound Human β
Kumar V; Hoag H; Sader S; Scorese N; Liu H; Wu C
J Chem Inf Model; 2020 Aug; 60(8):4064-4075. PubMed ID: 32786510
[TBL] [Abstract][Full Text] [Related]
14. Structure-Based Prediction of G-Protein-Coupled Receptor Ligand Function: A β-Adrenoceptor Case Study.
Kooistra AJ; Leurs R; de Esch IJ; de Graaf C
J Chem Inf Model; 2015 May; 55(5):1045-61. PubMed ID: 25848966
[TBL] [Abstract][Full Text] [Related]
15. Insight into partial agonism by observing multiple equilibria for ligand-bound and G
Solt AS; Bostock MJ; Shrestha B; Kumar P; Warne T; Tate CG; Nietlispach D
Nat Commun; 2017 Nov; 8(1):1795. PubMed ID: 29176642
[TBL] [Abstract][Full Text] [Related]
16. Biased signaling pathways in β2-adrenergic receptor characterized by 19F-NMR.
Liu JJ; Horst R; Katritch V; Stevens RC; Wüthrich K
Science; 2012 Mar; 335(6072):1106-10. PubMed ID: 22267580
[TBL] [Abstract][Full Text] [Related]
17. Activation/Deactivation Free-Energy Profiles for the β
Calderón JC; Ibrahim P; Gobbo D; Gervasio FL; Clark T
J Chem Inf Model; 2023 Oct; 63(20):6332-6343. PubMed ID: 37824365
[TBL] [Abstract][Full Text] [Related]
18. Ligand-dependent perturbation of the conformational ensemble for the GPCR β2 adrenergic receptor revealed by HDX.
West GM; Chien EY; Katritch V; Gatchalian J; Chalmers MJ; Stevens RC; Griffin PR
Structure; 2011 Oct; 19(10):1424-32. PubMed ID: 21889352
[TBL] [Abstract][Full Text] [Related]
19. Conformational and Thermodynamic Landscape of GPCR Activation from Theory and Computation.
Dong SS; Goddard WA; Abrol R
Biophys J; 2016 Jun; 110(12):2618-2629. PubMed ID: 27332120
[TBL] [Abstract][Full Text] [Related]
20. Understanding the effects on constitutive activation and drug binding of a D130N mutation in the β2 adrenergic receptor via molecular dynamics simulation.
Zhu Y; Yuan Y; Xiao X; Zhang L; Guo Y; Pu X
J Mol Model; 2014 Nov; 20(11):2491. PubMed ID: 25342155
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
