BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

192 related articles for article (PubMed ID: 33512434)

  • 1. Nras Q61R/+ and Kras-/- cooperate to downregulate Rasgrp1 and promote lympho-myeloid leukemia in early T-cell precursors.
    Wen Z; Yun G; Hebert A; Kong G; Ranheim EA; Finn R; Rajagoplan A; Li S; Zhou Y; Yu M; Damnernsawad A; Roose JP; Coon JJ; Wen R; Wang D; Zhang J
    Blood; 2021 Jun; 137(23):3259-3271. PubMed ID: 33512434
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Dysregulated RasGRP1 responds to cytokine receptor input in T cell leukemogenesis.
    Hartzell C; Ksionda O; Lemmens E; Coakley K; Yang M; Dail M; Harvey RC; Govern C; Bakker J; Lenstra TL; Ammon K; Boeter A; Winter SS; Loh M; Shannon K; Chakraborty AK; Wabl M; Roose JP
    Sci Signal; 2013 Mar; 6(268):ra21. PubMed ID: 23532335
    [TBL] [Abstract][Full Text] [Related]  

  • 3. RasGRP1 overexpression in T-ALL increases basal nucleotide exchange on Ras rendering the Ras/PI3K/Akt pathway responsive to protumorigenic cytokines.
    Ksionda O; Melton AA; Bache J; Tenhagen M; Bakker J; Harvey R; Winter SS; Rubio I; Roose JP
    Oncogene; 2016 Jul; 35(28):3658-68. PubMed ID: 26549032
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Increased baseline RASGRP1 signals enhance stem cell fitness during native hematopoiesis.
    Karra L; Romero-Moya D; Ksionda O; Krush M; Gu Z; Mues M; Depeille P; Mullighan C; Roose JP
    Oncogene; 2020 Nov; 39(45):6920-6934. PubMed ID: 32989257
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Unique dependence on Sos1 in
    You X; Kong G; Ranheim EA; Yang D; Zhou Y; Zhang J
    Blood; 2018 Dec; 132(24):2575-2579. PubMed ID: 30377195
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Adaptor SKAP-55 binds p21 activating exchange factor RasGRP1 and negatively regulates the p21-ERK pathway in T-cells.
    Schneider H; Wang H; Raab M; Valk E; Smith X; Lovatt M; Wu Z; Maqueira-Iglesias B; Strebhardt K; Rudd CE
    PLoS One; 2008 Mar; 3(3):e1718. PubMed ID: 18320039
    [TBL] [Abstract][Full Text] [Related]  

  • 7. PAQR10 and PAQR11 mediate Ras signaling in the Golgi apparatus.
    Jin T; Ding Q; Huang H; Xu D; Jiang Y; Zhou B; Li Z; Jiang X; He J; Liu W; Zhang Y; Pan Y; Wang Z; Thomas WG; Chen Y
    Cell Res; 2012 Apr; 22(4):661-76. PubMed ID: 21968647
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Loss of wild-type Kras promotes activation of all Ras isoforms in oncogenic Kras-induced leukemogenesis.
    Kong G; Chang YI; Damnernsawad A; You X; Du J; Ranheim EA; Lee W; Ryu MJ; Zhou Y; Xing Y; Chang Q; Burd CE; Zhang J
    Leukemia; 2016 Jul; 30(7):1542-51. PubMed ID: 27055865
    [TBL] [Abstract][Full Text] [Related]  

  • 9. RasGRP1 is essential for ras activation by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate in epidermal keratinocytes.
    Sharma A; Luke CT; Dower NA; Stone JC; Lorenzo PS
    J Biol Chem; 2010 May; 285(21):15724-30. PubMed ID: 20308057
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Downregulating Notch counteracts Kras
    Kong G; You X; Wen Z; Chang YI; Qian S; Ranheim EA; Letson C; Zhang X; Zhou Y; Liu Y; Rajagopalan A; Zhang J; Stieglitz E; Loh M; Hofmann I; Yang D; Zhong X; Padron E; Zhou L; Pear WS; Zhang J
    Leukemia; 2019 Mar; 33(3):671-685. PubMed ID: 30206308
    [TBL] [Abstract][Full Text] [Related]  

  • 11. RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth.
    Depeille P; Henricks LM; van de Ven RA; Lemmens E; Wang CY; Matli M; Werb Z; Haigis KM; Donner D; Warren R; Roose JP
    Nat Cell Biol; 2015 Jun; 17(6):804-15. PubMed ID: 26005835
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Loss of Dnmt3a and endogenous Kras(G12D/+) cooperate to regulate hematopoietic stem and progenitor cell functions in leukemogenesis.
    Chang YI; You X; Kong G; Ranheim EA; Wang J; Du J; Liu Y; Zhou Y; Ryu MJ; Zhang J
    Leukemia; 2015 Sep; 29(9):1847-56. PubMed ID: 25801914
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Aberrant expression of RasGRP1 cooperates with gain-of-function NOTCH1 mutations in T-cell leukemogenesis.
    Oki T; Kitaura J; Watanabe-Okochi N; Nishimura K; Maehara A; Uchida T; Komeno Y; Nakahara F; Harada Y; Sonoki T; Harada H; Kitamura T
    Leukemia; 2012 May; 26(5):1038-45. PubMed ID: 22116551
    [TBL] [Abstract][Full Text] [Related]  

  • 14. RAS oncogene suppression induces apoptosis followed by more differentiated and less myelosuppressive disease upon relapse of acute myeloid leukemia.
    Kim WI; Matise I; Diers MD; Largaespada DA
    Blood; 2009 Jan; 113(5):1086-96. PubMed ID: 18952898
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia.
    Pomeroy EJ; Lee LA; Lee RDW; Schirm DK; Temiz NA; Ma J; Gruber TA; Diaz-Flores E; Moriarity BS; Downing JR; Shannon KM; Largaespada DA; Eckfeldt CE
    Oncogene; 2017 Jun; 36(23):3263-3273. PubMed ID: 27991934
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Ezh2 Controls an Early Hematopoietic Program and Growth and Survival Signaling in Early T Cell Precursor Acute Lymphoblastic Leukemia.
    Danis E; Yamauchi T; Echanique K; Zhang X; Haladyna JN; Riedel SS; Zhu N; Xie H; Orkin SH; Armstrong SA; Bernt KM; Neff T
    Cell Rep; 2016 Mar; 14(8):1953-65. PubMed ID: 26904942
    [TBL] [Abstract][Full Text] [Related]  

  • 17. RasGRP1 transmits prodifferentiation TCR signaling that is crucial for CD4 T cell development.
    Priatel JJ; Chen X; Dhanji S; Abraham N; Teh HS
    J Immunol; 2006 Aug; 177(3):1470-80. PubMed ID: 16849453
    [TBL] [Abstract][Full Text] [Related]  

  • 18. RasGRP1 and RasGRP3 Are Required for Efficient Generation of Early Thymic Progenitors.
    Golec DP; Henao Caviedes LM; Baldwin TA
    J Immunol; 2016 Sep; 197(5):1743-53. PubMed ID: 27465532
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Early T-Cell Precursor Acute Lymphoblastic Leukemia in an Infant With an NRAS Q61R Mutation and Clinical Features of Juvenile Myelomonocytic Leukemia.
    Raikar SS; Scarborough JD; Sabnis H; Bergsagel J; Wu D; Cooper TM; Keller FG; Wood BL; Bunting ST
    Pediatr Blood Cancer; 2016 Sep; 63(9):1667-70. PubMed ID: 27145535
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells.
    Roose JP; Mollenauer M; Gupta VA; Stone J; Weiss A
    Mol Cell Biol; 2005 Jun; 25(11):4426-41. PubMed ID: 15899849
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.