These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
4. Population pharmacokinetics of moxifloxacin and its concentration-QT interval relationship modeling in Chinese healthy volunteers. Xu FY; Huang JH; He YC; Liang LY; Li LJ; Yang J; Yin F; Xu L; Zheng QS; Wang K Acta Pharmacol Sin; 2017 Nov; 38(11):1580-1588. PubMed ID: 28713157 [TBL] [Abstract][Full Text] [Related]
5. Baseline selection in concentration-QTc modeling: impact on assay sensitivity. Huang DP; Chen J; Tsong Y J Biopharm Stat; 2021 Mar; 31(2):168-179. PubMed ID: 32873122 [TBL] [Abstract][Full Text] [Related]
6. Is a thorough QTc study necessary? The role of modeling and simulation in evaluating the QTc prolongation potential of drugs. Rohatagi S; Carrothers TJ; Kuwabara-Wagg J; Khariton T J Clin Pharmacol; 2009 Nov; 49(11):1284-96. PubMed ID: 19734373 [TBL] [Abstract][Full Text] [Related]
7. Detection and impact of hysteresis when evaluating a drug's QTc effect using concentration-QTc analysis. Ferber G; Darpo B; Garnett C; Huang D; Marathe DD; Sun Y; Liu J J Pharmacokinet Pharmacodyn; 2021 Apr; 48(2):187-202. PubMed ID: 33118135 [TBL] [Abstract][Full Text] [Related]
8. Novel concentration-QTc models for early clinical studies with parallel placebo controls: A simulation study. Orihashi Y; Kumagai Y; Shiosakai K Pharm Stat; 2021 Mar; 20(2):375-389. PubMed ID: 33295138 [TBL] [Abstract][Full Text] [Related]
9. Combination of olanzapine and samidorphan has no clinically relevant effects on ECG parameters, including the QTc interval: Results from a phase 1 QT/QTc study. Sun L; Yagoda S; Xue H; Brown R; Nangia N; McDonnell D; Rege B; von Moltke L; Darpo B Prog Neuropsychopharmacol Biol Psychiatry; 2020 Jun; 100():109881. PubMed ID: 32004636 [TBL] [Abstract][Full Text] [Related]
10. Sugammadex is not associated with QT/QTc prolongation: methodology aspects of an intravenous moxifloxacin-controlled thorough QT study. de Kam PJ; van Kuijk J; Smeets J; Thomsen T; Peeters P Int J Clin Pharmacol Ther; 2012 Aug; 50(8):595-604. PubMed ID: 22735462 [TBL] [Abstract][Full Text] [Related]
11. A Thorough QT Study to Evaluate the Effects of Supratherapeutic Doses of Ledipasvir on the QTc Interval in Healthy Subjects. German P; Mathias A; Brainard DM; Song Q; Ling J; Kearney BP Clin Pharmacol Drug Dev; 2018 Aug; 7(6):641-651. PubMed ID: 29058821 [TBL] [Abstract][Full Text] [Related]
12. Effect of levetiracetam on cardiac repolarization in healthy subjects: a single-dose, randomized, placebo- and active-controlled, four-way crossover study. Hulhoven R; Rosillon D; Bridson WE; Meeus MA; Salas E; Stockis A Clin Ther; 2008 Feb; 30(2):260-70. PubMed ID: 18343264 [TBL] [Abstract][Full Text] [Related]
13. Evaluation of dependent variable, time effect, covariates, and covariation structure in concentration-QTc modeling: A simulation study. Huang DP; Xiao S; Dang Q; Tsong Y Pharm Stat; 2018 Sep; 17(5):607-614. PubMed ID: 29956449 [TBL] [Abstract][Full Text] [Related]
14. Relationship between antofloxacin concentration and QT prolongation and estimation of the possible false-positive rate. Liang LY; He YC; Li YF; Yang J; Xu FY; Li LJ; Huang JH; Wang K; Zheng QS Biomed Pharmacother; 2020 Oct; 130():110619. PubMed ID: 32795925 [TBL] [Abstract][Full Text] [Related]
15. Application of a probabilistic method for the determination of drug-induced QT prolongation in telemetered cynomolgus monkeys: effects of moxifloxacin. Holzgrefe HH; Cavero I; Buchanan LV; Gill MW; Durham SK J Pharmacol Toxicol Methods; 2007; 55(3):227-37. PubMed ID: 17097307 [TBL] [Abstract][Full Text] [Related]
16. Effect of nalmefene 20 and 80 mg on the corrected QT interval and T-wave morphology: a randomized, double-blind, parallel-group, placebo- and moxifloxacin-controlled, single-centre study. Matz J; Graff C; Vainio PJ; Kallio A; Højer AM; Struijk JJ; Kanters JK; Andersen MP; Toft E Clin Drug Investig; 2011 Nov; 31(11):799-811. PubMed ID: 21967071 [TBL] [Abstract][Full Text] [Related]