571 related articles for article (PubMed ID: 33536335)
1. SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.
Jo U; Murai Y; Chakka S; Chen L; Cheng K; Murai J; Saha LK; Miller Jenkins LM; Pommier Y
Proc Natl Acad Sci U S A; 2021 Feb; 118(6):. PubMed ID: 33536335
[TBL] [Abstract][Full Text] [Related]
2. L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage.
Higa LA; Banks D; Wu M; Kobayashi R; Sun H; Zhang H
Cell Cycle; 2006 Aug; 5(15):1675-80. PubMed ID: 16861906
[TBL] [Abstract][Full Text] [Related]
3. Checkpoint kinase ATR phosphorylates Cdt2, a substrate receptor of CRL4 ubiquitin ligase, and promotes the degradation of Cdt1 following UV irradiation.
Sakaguchi H; Takami T; Yasutani Y; Maeda T; Morino M; Ishii T; Shiomi Y; Nishitani H
PLoS One; 2012; 7(9):e46480. PubMed ID: 23029527
[TBL] [Abstract][Full Text] [Related]
4. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1.
Jin J; Arias EE; Chen J; Harper JW; Walter JC
Mol Cell; 2006 Sep; 23(5):709-21. PubMed ID: 16949367
[TBL] [Abstract][Full Text] [Related]
5. SLFN11 Blocks Stressed Replication Forks Independently of ATR.
Murai J; Tang SW; Leo E; Baechler SA; Redon CE; Zhang H; Al Abo M; Rajapakse VN; Nakamura E; Jenkins LMM; Aladjem MI; Pommier Y
Mol Cell; 2018 Feb; 69(3):371-384.e6. PubMed ID: 29395061
[TBL] [Abstract][Full Text] [Related]
6. DDB1 maintains genome integrity through regulation of Cdt1.
Lovejoy CA; Lock K; Yenamandra A; Cortez D
Mol Cell Biol; 2006 Nov; 26(21):7977-90. PubMed ID: 16940174
[TBL] [Abstract][Full Text] [Related]
7. Human CTC1 promotes TopBP1 stability and CHK1 phosphorylation in response to telomere dysfunction and global replication stress.
Ackerson SM; Gable CI; Stewart JA
Cell Cycle; 2020 Dec; 19(24):3491-3507. PubMed ID: 33269665
[TBL] [Abstract][Full Text] [Related]
8. ATR kinase inhibition induces unscheduled origin firing through a Cdc7-dependent association between GINS and And-1.
Moiseeva T; Hood B; Schamus S; O'Connor MJ; Conrads TP; Bakkenist CJ
Nat Commun; 2017 Nov; 8(1):1392. PubMed ID: 29123096
[TBL] [Abstract][Full Text] [Related]
9. Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.
Nishitani H; Sugimoto N; Roukos V; Nakanishi Y; Saijo M; Obuse C; Tsurimoto T; Nakayama KI; Nakayama K; Fujita M; Lygerou Z; Nishimoto T
EMBO J; 2006 Mar; 25(5):1126-36. PubMed ID: 16482215
[TBL] [Abstract][Full Text] [Related]
10. DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint.
Sansam CL; Shepard JL; Lai K; Ianari A; Danielian PS; Amsterdam A; Hopkins N; Lees JA
Genes Dev; 2006 Nov; 20(22):3117-29. PubMed ID: 17085480
[TBL] [Abstract][Full Text] [Related]
11. An evolutionarily conserved function of proliferating cell nuclear antigen for Cdt1 degradation by the Cul4-Ddb1 ubiquitin ligase in response to DNA damage.
Hu J; Xiong Y
J Biol Chem; 2006 Feb; 281(7):3753-6. PubMed ID: 16407242
[TBL] [Abstract][Full Text] [Related]
12. Inhibition of ATR-dependent feedback activation of Chk1 sensitises cancer cells to Chk1 inhibitor monotherapy.
Massey AJ
Cancer Lett; 2016 Dec; 383(1):41-52. PubMed ID: 27693461
[TBL] [Abstract][Full Text] [Related]
13. PARP Inhibition Increases the Reliance on ATR/CHK1 Checkpoint Signaling Leading to Synthetic Lethality-An Alternative Treatment Strategy for Epithelial Ovarian Cancer Cells Independent from HR Effectiveness.
Gralewska P; Gajek A; Marczak A; Mikuła M; Ostrowski J; Śliwińska A; Rogalska A
Int J Mol Sci; 2020 Dec; 21(24):. PubMed ID: 33352723
[TBL] [Abstract][Full Text] [Related]
14. CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation.
Higa LA; Wu M; Ye T; Kobayashi R; Sun H; Zhang H
Nat Cell Biol; 2006 Nov; 8(11):1277-83. PubMed ID: 17041588
[TBL] [Abstract][Full Text] [Related]
15. DNA damage induces Cdt1 proteolysis in fission yeast through a pathway dependent on Cdt2 and Ddb1.
Ralph E; Boye E; Kearsey SE
EMBO Rep; 2006 Nov; 7(11):1134-9. PubMed ID: 17039252
[TBL] [Abstract][Full Text] [Related]
16. Overexpression of TopBP1, a canonical ATR/Chk1 activator, paradoxically hinders ATR/Chk1 activation in cancer.
Liu K; Graves JD; Lin FT; Lin WC
J Biol Chem; 2021; 296():100382. PubMed ID: 33556369
[TBL] [Abstract][Full Text] [Related]
17. Targeting DNA Damage Response in Prostate Cancer by Inhibiting Androgen Receptor-CDC6-ATR-Chk1 Signaling.
Karanika S; Karantanos T; Li L; Wang J; Park S; Yang G; Zuo X; Song JH; Maity SN; Manyam GC; Broom B; Aparicio AM; Gallick GE; Troncoso P; Corn PG; Navone N; Zhang W; Li S; Thompson TC
Cell Rep; 2017 Feb; 18(8):1970-1981. PubMed ID: 28228262
[TBL] [Abstract][Full Text] [Related]
18. Proliferating cell nuclear antigen interacts with the CRL4 ubiquitin ligase subunit CDT2 in DNA synthesis-induced degradation of CDT1.
Leng F; Saxena L; Hoang N; Zhang C; Lee L; Li W; Gong X; Lu F; Sun H; Zhang H
J Biol Chem; 2018 Dec; 293(49):18879-18889. PubMed ID: 30301766
[TBL] [Abstract][Full Text] [Related]
19. Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation.
Liu S; Bekker-Jensen S; Mailand N; Lukas C; Bartek J; Lukas J
Mol Cell Biol; 2006 Aug; 26(16):6056-64. PubMed ID: 16880517
[TBL] [Abstract][Full Text] [Related]
20. Inhibition of the ATR-CHK1 Pathway in Ewing Sarcoma Cells Causes DNA Damage and Apoptosis via the CDK2-Mediated Degradation of RRM2.
Koppenhafer SL; Goss KL; Terry WW; Gordon DJ
Mol Cancer Res; 2020 Jan; 18(1):91-104. PubMed ID: 31649026
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
