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2. Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease. Belcher JD; Chen C; Nguyen J; Milbauer L; Abdulla F; Alayash AI; Smith A; Nath KA; Hebbel RP; Vercellotti GM Blood; 2014 Jan; 123(3):377-90. PubMed ID: 24277079 [TBL] [Abstract][Full Text] [Related]
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5. MASP-2 and MASP-3 inhibitors block complement activation, inflammation, and microvascular stasis in a murine model of vaso-occlusion in sickle cell disease. Belcher JD; Nguyen J; Chen C; Abdulla F; Conglin R; Ivy ZK; Cummings J; Dudler T; Vercellotti GM Transl Res; 2022 Nov; 249():1-12. PubMed ID: 35878790 [TBL] [Abstract][Full Text] [Related]
6. Soluble MD-2 and Heme in Sickle Cell Disease Plasma Promote Pro-Inflammatory Signaling in Endothelial Cells. Zhang P; Nguyen J; Abdulla F; Nelson AT; Beckman JD; Vercellotti GM; Belcher JD Front Immunol; 2021; 12():632709. PubMed ID: 33841413 [TBL] [Abstract][Full Text] [Related]
7. Oral carbon monoxide therapy in murine sickle cell disease: Beneficial effects on vaso-occlusion, inflammation and anemia. Belcher JD; Gomperts E; Nguyen J; Chen C; Abdulla F; Kiser ZM; Gallo D; Levy H; Otterbein LE; Vercellotti GM PLoS One; 2018; 13(10):e0205194. PubMed ID: 30308028 [TBL] [Abstract][Full Text] [Related]
8. Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction. Belcher JD; Chen C; Nguyen J; Abdulla F; Zhang P; Nguyen H; Nguyen P; Killeen T; Miescher SM; Brinkman N; Nath KA; Steer CJ; Vercellotti GM PLoS One; 2018; 13(4):e0196455. PubMed ID: 29694434 [TBL] [Abstract][Full Text] [Related]
9. MP4CO, a pegylated hemoglobin saturated with carbon monoxide, is a modulator of HO-1, inflammation, and vaso-occlusion in transgenic sickle mice. Belcher JD; Young M; Chen C; Nguyen J; Burhop K; Tran P; Vercellotti GM Blood; 2013 Oct; 122(15):2757-64. PubMed ID: 23908468 [TBL] [Abstract][Full Text] [Related]
10. Heme oxygenase-1 is a modulator of inflammation and vaso-occlusion in transgenic sickle mice. Belcher JD; Mahaseth H; Welch TE; Otterbein LE; Hebbel RP; Vercellotti GM J Clin Invest; 2006 Mar; 116(3):808-16. PubMed ID: 16485041 [TBL] [Abstract][Full Text] [Related]
11. Thrombin activation of PAR-1 contributes to microvascular stasis in mouse models of sickle cell disease. Sparkenbaugh EM; Chen C; Brzoska T; Nguyen J; Wang S; Vercellotti GM; Key NS; Sundd P; Belcher JD; Pawlinski R Blood; 2020 May; 135(20):1783-1787. PubMed ID: 31977004 [TBL] [Abstract][Full Text] [Related]
12. Sickle red blood cell-derived extracellular vesicles activate endothelial cells and enhance sickle red cell adhesion mediated by von Willebrand factor. An R; Man Y; Cheng K; Zhang T; Chen C; Wang F; Abdulla F; Kucukal E; Wulftange WJ; Goreke U; Bode A; Nayak LV; Vercellotti GM; Belcher JD; Little JA; Gurkan UA Br J Haematol; 2023 May; 201(3):552-563. PubMed ID: 36604837 [TBL] [Abstract][Full Text] [Related]
13. Control of Oxidative Stress and Inflammation in Sickle Cell Disease with the Nrf2 Activator Dimethyl Fumarate. Belcher JD; Chen C; Nguyen J; Zhang P; Abdulla F; Nguyen P; Killeen T; Xu P; O'Sullivan G; Nath KA; Vercellotti GM Antioxid Redox Signal; 2017 May; 26(14):748-762. PubMed ID: 26914345 [TBL] [Abstract][Full Text] [Related]
14. Hepatic Overexpression of Hemopexin Inhibits Inflammation and Vascular Stasis in Murine Models of Sickle Cell Disease. Vercellotti GM; Zhang P; Nguyen J; Abdulla F; Chen C; Nguyen P; Nowotny C; Steer CJ; Smith A; Belcher JD Mol Med; 2016 Sep; 22():437-451. PubMed ID: 27451971 [TBL] [Abstract][Full Text] [Related]
15. HbS promotes TLR4-mediated monocyte activation and proinflammatory cytokine production in sickle cell disease. Allali S; Rignault-Bricard R; de Montalembert M; Taylor M; Bouceba T; Hermine O; Maciel TT Blood; 2022 Nov; 140(18):1972-1982. PubMed ID: 35984906 [TBL] [Abstract][Full Text] [Related]
16. Heme Causes Pain in Sickle Mice Lei J; Paul J; Wang Y; Gupta M; Vang D; Thompson S; Jha R; Nguyen J; Valverde Y; Lamarre Y; Jones MK; Gupta K Antioxid Redox Signal; 2021 Feb; 34(4):279-293. PubMed ID: 32729340 [No Abstract] [Full Text] [Related]
17. The BACH1 inhibitor ASP8731 inhibits inflammation and vaso-occlusion and induces fetal hemoglobin in sickle cell disease. Belcher JD; Nataraja S; Abdulla F; Zhang P; Chen C; Nguyen J; Ruan C; Singh M; Demes S; Olson L; Stickens D; Stanwix J; Clarke E; Huang Y; Biddle M; Vercellotti GM Front Med (Lausanne); 2023; 10():1101501. PubMed ID: 37144034 [TBL] [Abstract][Full Text] [Related]
18. Interaction of sickle erythrocytes with endothelial cells in the presence of endothelial cell conditioned medium induces oxidant stress leading to transendothelial migration of monocytes. Sultana C; Shen Y; Rattan V; Johnson C; Kalra VK Blood; 1998 Nov; 92(10):3924-35. PubMed ID: 9808586 [TBL] [Abstract][Full Text] [Related]
19. Plasma-Derived Hemopexin as a Candidate Therapeutic Agent for Acute Vaso-Occlusion in Sickle Cell Disease: Preclinical Evidence. Gentinetta T; Belcher JD; Brügger-Verdon V; Adam J; Ruthsatz T; Bain J; Schu D; Ventrici L; Edler M; Lioe H; Patel K; Chen C; Nguyen J; Abdulla F; Zhang P; Wassmer A; Jain M; Mischnik M; Pelzing M; Martin K; Davis R; Didichenko S; Schaub A; Brinkman N; Herzog E; Zürcher A; Vercellotti GM; Kato GJ; Höbarth G J Clin Med; 2022 Jan; 11(3):. PubMed ID: 35160081 [TBL] [Abstract][Full Text] [Related]
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