BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

498 related articles for article (PubMed ID: 33550186)

  • 21. Potent colchicine-site ligands with improved intrinsic solubility by replacement of the 3,4,5-trimethoxyphenyl ring with a 2-methylsulfanyl-6-methoxypyridine ring.
    Álvarez R; Aramburu L; Gajate C; Vicente-Blázquez A; Mollinedo F; Medarde M; Peláez R
    Bioorg Chem; 2020 May; 98():103755. PubMed ID: 32200330
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Design, synthesis, and biological evaluation of novel benzodiazepine derivatives as anticancer agents through inhibition of tubulin polymerization in vitro and in vivo.
    Pang Y; Lin H; Ou C; Cao Y; An B; Yan J; Li X
    Eur J Med Chem; 2019 Nov; 182():111670. PubMed ID: 31499359
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Modification of the phenyl ring B of phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates by pyridinyl moiety leads to novel antimitotics targeting the colchicine-binding site.
    Ouellette V; Bouzriba C; Chavez Alvarez AC; Hamel-Côté G; Fortin S
    Bioorg Med Chem Lett; 2024 Jun; 105():129745. PubMed ID: 38614151
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral β-lactam bridged combretastatin A-4 analogues as potent antitumor agents.
    Zhou P; Liang Y; Zhang H; Jiang H; Feng K; Xu P; Wang J; Wang X; Ding K; Luo C; Liu M; Wang Y
    Eur J Med Chem; 2018 Jan; 144():817-842. PubMed ID: 29306206
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Structure-activity relationships and antiproliferative effects of 1,2,3,4-4H-quinoxaline derivatives as tubulin polymerization inhibitors.
    Liang T; Zhou X; Lu L; Dong H; Zhang Y; Xu Y; Qi J; Zhang Y; Wang J
    Bioorg Chem; 2021 May; 110():104793. PubMed ID: 33770673
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Design, synthesis, and bioevaluation of pyrazolo[1,5-a]pyrimidine derivatives as tubulin polymerization inhibitors targeting the colchicine binding site with potent anticancer activities.
    Li G; Wang Y; Li L; Ren Y; Deng X; Liu J; Wang W; Luo M; Liu S; Chen J
    Eur J Med Chem; 2020 Sep; 202():112519. PubMed ID: 32650183
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Discovery of new quinolines as potent colchicine binding site inhibitors: design, synthesis, docking studies, and anti-proliferative evaluation.
    Hagras M; El Deeb MA; Elzahabi HSA; Elkaeed EB; Mehany ABM; Eissa IH
    J Enzyme Inhib Med Chem; 2021 Dec; 36(1):640-658. PubMed ID: 33588683
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Synthesis, antimitotic and antivascular activity of 1-(3',4',5'-trimethoxybenzoyl)-3-arylamino-5-amino-1,2,4-triazoles.
    Romagnoli R; Baraldi PG; Salvador MK; Prencipe F; Bertolasi V; Cancellieri M; Brancale A; Hamel E; Castagliuolo I; Consolaro F; Porcù E; Basso G; Viola G
    J Med Chem; 2014 Aug; 57(15):6795-808. PubMed ID: 25025853
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Design, synthesis and antitumor evaluation of novel chiral diaryl substituted azetidin-2-one derivatives as tubulin polymerization inhibitors.
    Liang Y; Zhang M; Zhou P; Liu M; Li J; Wang Y
    Bioorg Chem; 2021 Oct; 115():105239. PubMed ID: 34399321
    [TBL] [Abstract][Full Text] [Related]  

  • 30. New pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancer.
    La Regina G; Bai R; Coluccia A; Famiglini V; Pelliccia S; Passacantilli S; Mazzoccoli C; Ruggieri V; Sisinni L; Bolognesi A; Rensen WM; Miele A; Nalli M; Alfonsi R; Di Marcotullio L; Gulino A; Brancale A; Novellino E; Dondio G; Vultaggio S; Varasi M; Mercurio C; Hamel E; Lavia P; Silvestri R
    J Med Chem; 2014 Aug; 57(15):6531-52. PubMed ID: 25025991
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Design, synthesis and biological evaluation of colchicine glycoconjugates as tubulin polymerization inhibitors.
    Wang Z; Liu R; Zhang X; Chang X; Gao M; Zhang S; Guan Q; Sun J; Zuo D; Zhang W
    Bioorg Med Chem; 2022 Mar; 58():116671. PubMed ID: 35193066
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Synthesis, biological evaluation, and molecular modelling of new naphthalene-chalcone derivatives as potential anticancer agents on MCF-7 breast cancer cells by targeting tubulin colchicine binding site.
    Wang G; Liu W; Gong Z; Huang Y; Li Y; Peng Z
    J Enzyme Inhib Med Chem; 2020 Dec; 35(1):139-144. PubMed ID: 31724435
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Synthesis, biological evaluation, and structure-activity relationships of new tubulin polymerization inhibitors based on 5-amino-1,2,4-triazole scaffold.
    Yang F; Chen L; Lai JM; Jian XE; Lv DX; Yuan LL; Liu YX; Liang FT; Zheng XL; Li XL; Wei LY; You WW; Zhao PL
    Bioorg Med Chem Lett; 2021 Apr; 38():127880. PubMed ID: 33636303
    [TBL] [Abstract][Full Text] [Related]  

  • 34. A 2-step synthesis of Combretastatin A-4 and derivatives as potent tubulin assembly inhibitors.
    Barnes NG; Parker AW; Ahmed Mal Ullah AA; Ragazzon PA; Hadfield JA
    Bioorg Med Chem; 2020 Oct; 28(19):115684. PubMed ID: 32912434
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Design, synthesis, and evaluations of the antiproliferative activity and aqueous solubility of novel carbazole sulfonamide derivatives as antitumor agents.
    Sun L; Wang C; Hu X; Wu Y; Jiang Z; Li Z; Chen X; Hu L
    Bioorg Chem; 2020 Jun; 99():103766. PubMed ID: 32247110
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Novel [1,2,4]triazolo[1,5-a]pyrimidine derivatives as potent antitubulin agents: Design, multicomponent synthesis and antiproliferative activities.
    Yang F; Yu LZ; Diao PC; Jian XE; Zhou MF; Jiang CS; You WW; Ma WF; Zhao PL
    Bioorg Chem; 2019 Nov; 92():103260. PubMed ID: 31525523
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Design, synthesis and structure-activity relationship of 3,6-diaryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines as novel tubulin inhibitors.
    Xu Q; Bao K; Sun M; Xu J; Wang Y; Tian H; Zuo D; Guan Q; Wu Y; Zhang W
    Sci Rep; 2017 Sep; 7(1):11997. PubMed ID: 28931885
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Design, synthesis and biological evaluation of novel imidazole-chalcone derivatives as potential anticancer agents and tubulin polymerization inhibitors.
    Rahimzadeh Oskuei S; Mirzaei S; Reza Jafari-Nik M; Hadizadeh F; Eisvand F; Mosaffa F; Ghodsi R
    Bioorg Chem; 2021 Jul; 112():104904. PubMed ID: 33933802
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Tubulin inhibitors: Discovery of a new scaffold targeting extra-binding residues within the colchicine site through anchoring substituents properly adapted to their pocket by a semi-flexible linker.
    Maklad RM; AbdelHafez EMN; Abdelhamid D; Aly OM
    Bioorg Chem; 2020 Jun; 99():103767. PubMed ID: 32325332
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Synthesis, antiproliferative, anti-tubulin activity, and docking study of new 1,2,4-triazoles as potential combretastatin analogues.
    Mustafa M; Abdelhamid D; Abdelhafez EMN; Ibrahim MAA; Gamal-Eldeen AM; Aly OM
    Eur J Med Chem; 2017 Dec; 141():293-305. PubMed ID: 29031074
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 25.