BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

145 related articles for article (PubMed ID: 33592148)

  • 1. Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A
    Markert C; Thoma G; Srinivas H; Bollbuck B; Lüönd RM; Miltz W; Wälchli R; Wolf R; Hinrichs J; Bergsdorf C; Azzaoui K; Penno CA; Klein K; Wack N; Jäger P; Hasler F; Beerli C; Loetscher P; Dawson J; Wieczorek G; Numao S; Littlewood-Evans A; Röhn TA
    J Med Chem; 2021 Feb; 64(4):1889-1903. PubMed ID: 33592148
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Drug discovery strategies for novel leukotriene A4 hydrolase inhibitors.
    Röhn TA; Numao S; Otto H; Loesche C; Thoma G
    Expert Opin Drug Discov; 2021 Dec; 16(12):1483-1495. PubMed ID: 34191664
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Identification of Human Leukotriene A4 Hydrolase Inhibitors Using Structure-Based Pharmacophore Modeling and Molecular Docking.
    Audat SA; Al-Shar'i NA; Al-Oudat BA; Bryant-Friedrich A; Bedi MF; Zayed AL; Al-Balas QA
    Molecules; 2020 Jun; 25(12):. PubMed ID: 32580506
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The development of novel LTA
    Low CM; Akthar S; Patel DF; Löser S; Wong CT; Jackson PL; Blalock JE; Hare SA; Lloyd CM; Snelgrove RJ
    Sci Rep; 2017 Mar; 7():44449. PubMed ID: 28303931
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Feasibility and physiological relevance of designing highly potent aminopeptidase-sparing leukotriene A4 hydrolase inhibitors.
    Numao S; Hasler F; Laguerre C; Srinivas H; Wack N; Jäger P; Schmid A; Osmont A; Röthlisberger P; Houguenade J; Bergsdorf C; Dawson J; Carte N; Hofmann A; Markert C; Hardaker L; Billich A; Wolf RM; Penno CA; Bollbuck B; Miltz W; Röhn TA
    Sci Rep; 2017 Oct; 7(1):13591. PubMed ID: 29051536
    [TBL] [Abstract][Full Text] [Related]  

  • 6. LTA4H inhibitor LYS006: Clinical PK/PD and safety in a randomized phase I clinical trial.
    Loesche C; Picard D; Van Hoorick B; Schuhmann I; Jäger P; Klein K; Schuhler C; Thoma G; Markert C; Poller B; Zamurovic N; Weiss HM; Otto H; Fink M; Röhn TA
    Clin Transl Sci; 2024 Feb; 17(2):e13724. PubMed ID: 38407540
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Leukotriene A4 hydrolase as a target for cancer prevention and therapy.
    Chen X; Wang S; Wu N; Yang CS
    Curr Cancer Drug Targets; 2004 May; 4(3):267-83. PubMed ID: 15134534
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Modulation of inflammatory disease by inhibitors of leukotriene A4 hydrolase.
    Fourie AM
    Curr Opin Investig Drugs; 2009 Nov; 10(11):1173-82. PubMed ID: 19876785
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Hybrid Receptor-Bound/MM-GBSA-Per-residue Energy-Based Pharmacophore Modelling: Enhanced Approach for Identification of Selective LTA4H Inhibitors as Potential Anti-inflammatory Drugs.
    Appiah-Kubi P; Soliman M
    Cell Biochem Biophys; 2017 Mar; 75(1):35-48. PubMed ID: 27914004
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Dual anti-inflammatory and selective inhibition mechanism of leukotriene A4 hydrolase/aminopeptidase: insights from comparative molecular dynamics and binding free energy analyses.
    Appiah-Kubi P; Soliman ME
    J Biomol Struct Dyn; 2016 Nov; 34(11):2418-33. PubMed ID: 26555301
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Structure-Guided Elaboration of a Fragment-Like Hit into an Orally Efficacious Leukotriene A4 Hydrolase Inhibitor.
    Thoma G; Miltz W; Srinivas H; Penno CA; Kiffe M; Gajewska M; Klein K; Evans A; Beerli C; Röhn TA
    J Med Chem; 2024 Mar; 67(6):5093-5108. PubMed ID: 38476002
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Thermodynamic properties of leukotriene A
    Wittmann SK; Kalinowsky L; Kramer JS; Bloecher R; Knapp S; Steinhilber D; Pogoryelov D; Proschak E; Heering J
    Bioorg Med Chem; 2016 Nov; 24(21):5243-5248. PubMed ID: 27651294
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Classification and QSAR models of leukotriene A4 hydrolase (LTA4H) inhibitors by machine learning methods.
    Qin R; Wang H; Yan A
    SAR QSAR Environ Res; 2021 May; 32(5):411-431. PubMed ID: 33896285
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A sensitive fluorigenic substrate for selective in vitro and in vivo assay of leukotriene A4 hydrolase activity.
    Poras H; Duquesnoy S; Fournié-Zaluski MC; Ratinaud-Giraud C; Roques BP; Ouimet T
    Anal Biochem; 2013 Oct; 441(2):152-61. PubMed ID: 23851339
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography.
    Davies DR; Mamat B; Magnusson OT; Christensen J; Haraldsson MH; Mishra R; Pease B; Hansen E; Singh J; Zembower D; Kim H; Kiselyov AS; Burgin AB; Gurney ME; Stewart LJ
    J Med Chem; 2009 Aug; 52(15):4694-715. PubMed ID: 19618939
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Inhibition of Leukotriene A
    Wu X; Sun AR; Crawford R; Xiao Y; Wang Y; Prasadam I; Mao X
    Cartilage; 2024 Jun; 15(2):184-194. PubMed ID: 37086004
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Discovery of Amino Alcohols as Highly Potent, Selective, and Orally Efficacious Inhibitors of Leukotriene A4 Hydrolase.
    Thoma G; Markert C; Lueoend R; Miltz W; Spanka C; Bollbuck B; Wolf RM; Srinivas H; Penno CA; Kiffe M; Gajewska M; Bednarczyk D; Wieczorek G; Evans A; Beerli C; Röhn TA
    J Med Chem; 2023 Dec; 66(23):16410-16425. PubMed ID: 38015154
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Leukotriene A4 hydrolase in rat and human esophageal adenocarcinomas and inhibitory effects of bestatin.
    Chen X; Li N; Wang S; Wu N; Hong J; Jiao X; Krasna MJ; Beer DG; Yang CS
    J Natl Cancer Inst; 2003 Jul; 95(14):1053-61. PubMed ID: 12865451
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Design and synthesis of Leukotriene A4 hydrolase inhibitors to alleviate idiopathic pulmonary fibrosis and acute lung injury.
    Li X; Xie M; Lu C; Mao J; Cao Y; Yang Y; Wei Y; Liu X; Cao S; Song Y; Peng J; Zhou Y; Jiang Q; Lin G; Qin S; Qi M; Hou M; Liu X; Zhou H; Yang G; Yang C
    Eur J Med Chem; 2020 Oct; 203():112614. PubMed ID: 32679453
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis, docking, cytotoxicity, and LTA
    El-Naggar MH; Mira A; Abdel Bar FM; Shimizu K; Amer MM; Badria FA
    Bioorg Med Chem; 2017 Feb; 25(3):1277-1285. PubMed ID: 28065501
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.