138 related articles for article (PubMed ID: 33593051)
1. Discovery of 3-(4-(2-((1
Zhang C; Qi W; Li Y; Tang M; Yang T; Liu K; Chen Y; Deng D; Xiang M; Chen L
J Med Chem; 2021 Feb; 64(4):1966-1988. PubMed ID: 33593051
[TBL] [Abstract][Full Text] [Related]
2. Identification of a Novel 2,8-Diazaspiro[4.5]decan-1-one Derivative as a Potent and Selective Dual TYK2/JAK1 Inhibitor for the Treatment of Inflammatory Bowel Disease.
Yang T; Cui X; Tang M; Qi W; Zhu Z; Shi M; Yang L; Pei H; Zhang W; Xie L; Xu Y; Yang Z; Chen L
J Med Chem; 2022 Feb; 65(4):3151-3172. PubMed ID: 35113547
[TBL] [Abstract][Full Text] [Related]
3. Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841).
Fensome A; Ambler CM; Arnold E; Banker ME; Brown MF; Chrencik J; Clark JD; Dowty ME; Efremov IV; Flick A; Gerstenberger BS; Gopalsamy A; Hayward MM; Hegen M; Hollingshead BD; Jussif J; Knafels JD; Limburg DC; Lin D; Lin TH; Pierce BS; Saiah E; Sharma R; Symanowicz PT; Telliez JB; Trujillo JI; Vajdos FF; Vincent F; Wan ZK; Xing L; Yang X; Yang X; Zhang L
J Med Chem; 2018 Oct; 61(19):8597-8612. PubMed ID: 30113844
[TBL] [Abstract][Full Text] [Related]
4. Discovery of selective TYK2 inhibitors: Design, synthesis, in vitro and in silico studies of promising hits with triazolopyrimidinone scaffold.
Istanbullu H; Coban G; Turunc E; Disel C; Debelec Butuner B
Bioorg Chem; 2024 Jul; 148():107430. PubMed ID: 38728909
[TBL] [Abstract][Full Text] [Related]
5. Discovery of (2
Su Q; Banks E; Bebernitz G; Bell K; Borenstein CF; Chen H; Chuaqui CE; Deng N; Ferguson AD; Kawatkar S; Grimster NP; Ruston L; Lyne PD; Read JA; Peng X; Pei X; Fawell S; Tang Z; Throner S; Vasbinder MM; Wang H; Winter-Holt J; Woessner R; Wu A; Yang W; Zinda M; Kettle JG
J Med Chem; 2020 May; 63(9):4517-4527. PubMed ID: 32297743
[TBL] [Abstract][Full Text] [Related]
6. Development of selective inhibitors for the treatment of rheumatoid arthritis: (R)-3-(3-(Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)pyrrolidin-1-yl)-3-oxopropanenitrile as a JAK1-selective inhibitor.
Chough C; Joung M; Lee S; Lee J; Kim JH; Kim BM
Bioorg Med Chem; 2018 May; 26(8):1495-1510. PubMed ID: 29452839
[TBL] [Abstract][Full Text] [Related]
7. A novel highly selective allosteric inhibitor of tyrosine kinase 2 (TYK2) can block inflammation- and autoimmune-related pathways.
Chen CX; Zhang W; Qu S; Xia F; Zhu Y; Chen B
Cell Commun Signal; 2023 Oct; 21(1):287. PubMed ID: 37845748
[TBL] [Abstract][Full Text] [Related]
8. Discovery of Tyrosine Kinase 2 (TYK2) Inhibitor (PF-06826647) for the Treatment of Autoimmune Diseases.
Gerstenberger BS; Ambler C; Arnold EP; Banker ME; Brown MF; Clark JD; Dermenci A; Dowty ME; Fensome A; Fish S; Hayward MM; Hegen M; Hollingshead BD; Knafels JD; Lin DW; Lin TH; Owen DR; Saiah E; Sharma R; Vajdos FF; Xing L; Yang X; Yang X; Wright SW
J Med Chem; 2020 Nov; 63(22):13561-13577. PubMed ID: 32787094
[TBL] [Abstract][Full Text] [Related]
9. Synthesis, evaluation and docking of novel pyrazolo pyrimidines as potent p38α MAP kinase inhibitors with improved anti-inflammatory, ulcerogenic and TNF-α inhibitory properties.
Somakala K; Tariq S; Amir M
Bioorg Chem; 2019 Jun; 87():550-559. PubMed ID: 30928877
[TBL] [Abstract][Full Text] [Related]
10. Discovery of 5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a novel inhibitor of the Jak/Stat pathway.
Ioannidis S; Lamb ML; Wang T; Almeida L; Block MH; Davies AM; Peng B; Su M; Zhang HJ; Hoffmann E; Rivard C; Green I; Howard T; Pollard H; Read J; Alimzhanov M; Bebernitz G; Bell K; Ye M; Huszar D; Zinda M
J Med Chem; 2011 Jan; 54(1):262-76. PubMed ID: 21138246
[TBL] [Abstract][Full Text] [Related]
11. Discovery and SARs of 5-Chloro-
Wang Y; Chen X; Yan Y; Zhu X; Liu M; Liu X
J Med Chem; 2020 Mar; 63(6):3327-3347. PubMed ID: 32129996
[TBL] [Abstract][Full Text] [Related]
12. Discovery of
Che J; Dai X; Gao J; Sheng H; Zhan W; Lu Y; Li D; Gao Z; Jin Z; Chen B; Luo P; Yang B; Hu Y; He Q; Weng Q; Dong X
J Med Chem; 2021 Aug; 64(16):12163-12180. PubMed ID: 34375113
[TBL] [Abstract][Full Text] [Related]
13. Evaluation of WO2013125543, WO2013146963 and EP2634185: the first Tyk2 inhibitors from Takeda and Sareum.
Norman P
Expert Opin Ther Pat; 2014 Mar; 24(3):361-8. PubMed ID: 24386992
[TBL] [Abstract][Full Text] [Related]
14. Discovery of 3-alkyl-5-aryl-1-pyrimidyl-1
Oh Y; Jang M; Cho H; Yang S; Im D; Moon H; Hah JM
J Enzyme Inhib Med Chem; 2020 Dec; 35(1):372-376. PubMed ID: 31856610
[TBL] [Abstract][Full Text] [Related]
15.
Yang T; Hu M; Chen Y; Xiang M; Tang M; Qi W; Shi M; He J; Yuan X; Zhang C; Liu K; Li J; Yang Z; Chen L
J Med Chem; 2020 Dec; 63(23):14921-14936. PubMed ID: 33256400
[TBL] [Abstract][Full Text] [Related]
16. Lead identification of novel and selective TYK2 inhibitors.
Liang J; Tsui V; Van Abbema A; Bao L; Barrett K; Beresini M; Berezhkovskiy L; Blair WS; Chang C; Driscoll J; Eigenbrot C; Ghilardi N; Gibbons P; Halladay J; Johnson A; Kohli PB; Lai Y; Liimatta M; Mantik P; Menghrajani K; Murray J; Sambrone A; Xiao Y; Shia S; Shin Y; Smith J; Sohn S; Stanley M; Ultsch M; Zhang B; Wu LC; Magnuson S
Eur J Med Chem; 2013 Sep; 67():175-87. PubMed ID: 23867602
[TBL] [Abstract][Full Text] [Related]
17. Design, synthesis, biological evaluation, and docking studies of novel (imidazol-5-yl)pyrimidine-based derivatives as dual BRAF
Ali EMH; El-Telbany RFA; Abdel-Maksoud MS; Ammar UM; Mersal KI; Zaraei SO; El-Gamal MI; Choi SI; Lee KT; Kim HK; Lee KH; Oh CH
Eur J Med Chem; 2021 Apr; 215():113277. PubMed ID: 33601311
[TBL] [Abstract][Full Text] [Related]
18. Design, synthesis and biological evaluation of novel N-(methyl-d
Liu F; Wang B; Liu Y; Shi W; Hu Z; Chang X; Tang X; Zhang Y; Xu H; He Y
Bioorg Med Chem Lett; 2023 Apr; 86():129235. PubMed ID: 36907336
[TBL] [Abstract][Full Text] [Related]
19. Selective Tyrosine Kinase 2 Inhibition for Treatment of Inflammatory Bowel Disease: New Hope on the Rise.
Danese S; Peyrin-Biroulet L
Inflamm Bowel Dis; 2021 Nov; 27(12):2023-2030. PubMed ID: 34089259
[TBL] [Abstract][Full Text] [Related]
20. Design and optimization of a series of 4-(3-azabicyclo[3.1.0]hexan-3-yl)pyrimidin-2-amines: Dual inhibitors of TYK2 and JAK1.
Fensome A; Ambler CM; Arnold E; Banker ME; Clark JD; Dowty ME; Efremov IV; Flick A; Gerstenberger BS; Gifford RS; Gopalsamy A; Hegen M; Jussif J; Limburg DC; Lin TH; Pierce BS; Sharma R; Trujillo JI; Vajdos FF; Vincent F; Wan ZK; Xing L; Yang X; Yang X
Bioorg Med Chem; 2020 May; 28(10):115481. PubMed ID: 32253095
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
