387 related articles for article (PubMed ID: 33600922)
1. Triptolide and atorvastatin synergistically promote hepatotoxicity in cultured hepatocytes and female Sprague-Dawley rats by inhibiting pregnane X receptor-mediated transcriptional activation of CYP3A4.
Zheng N; Wei A; Wu T; Long L; Yang H; Li H; Wang L
Toxicol Lett; 2021 May; 342():85-94. PubMed ID: 33600922
[TBL] [Abstract][Full Text] [Related]
2. Role of CYP3A in regulating hepatic clearance and hepatotoxicity of triptolide in rat liver microsomes and sandwich-cultured hepatocytes.
Shen G; Zhuang X; Xiao W; Kong L; Tan Y; Li H
Food Chem Toxicol; 2014 Sep; 71():90-6. PubMed ID: 24910460
[TBL] [Abstract][Full Text] [Related]
3. Assessment of the roles of P-glycoprotein and cytochrome P450 in triptolide-induced liver toxicity in sandwich-cultured rat hepatocyte model.
Zhuang XM; Shen GL; Xiao WB; Tan Y; Lu C; Li H
Drug Metab Dispos; 2013 Dec; 41(12):2158-65. PubMed ID: 24065861
[TBL] [Abstract][Full Text] [Related]
4. Comparison of toxicokinetic and tissue distribution of triptolide-loaded solid lipid nanoparticles vs free triptolide in rats.
Xue M; Zhao Y; Li XJ; Jiang ZZ; Zhang L; Liu SH; Li XM; Zhang LY; Yang SY
Eur J Pharm Sci; 2012 Nov; 47(4):713-7. PubMed ID: 22677813
[TBL] [Abstract][Full Text] [Related]
5. Nanostructured lipid carriers as a novel oral delivery system for triptolide: induced changes in pharmacokinetics profile associated with reduced toxicity in male rats.
Zhang C; Peng F; Liu W; Wan J; Wan C; Xu H; Lam CW; Yang X
Int J Nanomedicine; 2014; 9():1049-63. PubMed ID: 24591827
[TBL] [Abstract][Full Text] [Related]
6. CYP3A4 inducer and inhibitor strongly affect the pharmacokinetics of triptolide and its derivative in rats.
Xu Y; Zhang YF; Chen XY; Zhong DF
Acta Pharmacol Sin; 2018 Aug; 39(8):1386-1392. PubMed ID: 29283173
[TBL] [Abstract][Full Text] [Related]
7. Inhibition of P-glycoprotein Gene Expression and Function Enhances Triptolide-induced Hepatotoxicity in Mice.
Kong LL; Zhuang XM; Yang HY; Yuan M; Xu L; Li H
Sci Rep; 2015 Jul; 5():11747. PubMed ID: 26134275
[TBL] [Abstract][Full Text] [Related]
8. Catalpol coordinately regulates phase I and II detoxification enzymes of Triptolide through CAR and NRF2 pathways to reduce Triptolide-induced hepatotoxicity.
Fu L; Zhou L; Geng S; Li M; Lu W; Lu Y; Feng Z; Zhou X
Biomed Pharmacother; 2020 Sep; 129():110379. PubMed ID: 32563148
[TBL] [Abstract][Full Text] [Related]
9. In vivo effect of triptolide combined with glycyrrhetinic acid on rat cytochrome P450 enzymes.
Han FM; Peng ZH; Wang JJ; Chen Y
Yao Xue Xue Bao; 2013 Jul; 48(7):1136-41. PubMed ID: 24133982
[TBL] [Abstract][Full Text] [Related]
10. The research on the anti-inflammatory activity and hepatotoxicity of triptolide-loaded solid lipid nanoparticle.
Mei Z; Li X; Wu Q; Hu S; Yang X
Pharmacol Res; 2005 Apr; 51(4):345-51. PubMed ID: 15683748
[TBL] [Abstract][Full Text] [Related]
11. Circadian clock regulates hepatotoxicity of Tripterygium wilfordii through modulation of metabolism.
Zhao H; Tong Y; Lu D; Wu B
J Pharm Pharmacol; 2020 Dec; 72(12):1854-1864. PubMed ID: 32478421
[TBL] [Abstract][Full Text] [Related]
12. Triptolide impairs thioredoxin system by suppressing Notch1-mediated PTEN/Akt/Txnip signaling in hepatocytes.
Shen F; Xiong Z; Kong J; Wang L; Cheng Y; Jin J; Huang Z
Toxicol Lett; 2019 Jan; 300():105-115. PubMed ID: 30394310
[TBL] [Abstract][Full Text] [Related]
13. Triptolide Induces hepatotoxicity via inhibition of CYP450s in Rat liver microsomes.
Lu Y; Xie T; Zhang Y; Zhou F; Ruan J; Zhu W; Zhu H; Feng Z; Zhou X
BMC Complement Altern Med; 2017 Jan; 17(1):15. PubMed ID: 28056947
[TBL] [Abstract][Full Text] [Related]
14. Integrated targeted sphingolipidomics and transcriptomics reveal abnormal sphingolipid metabolism as a novel mechanism of the hepatotoxicity and nephrotoxicity of triptolide.
Qu L; Qu F; Jia Z; Wang C; Wu C; Zhang J
J Ethnopharmacol; 2015 Jul; 170():28-38. PubMed ID: 25978956
[TBL] [Abstract][Full Text] [Related]
15. Assessment of Feng-Liao-Chang-Wei-Kang as a potential inducer of cytochrome P450 3A4 and pregnane X receptors.
Xie Y; Li Y; Huang M; Wu Q; Liu Q; Zhang J; Deng H; Liu M; Huang L
Pak J Pharm Sci; 2018 Sep; 31(5(Special)):2315-2321. PubMed ID: 30463833
[TBL] [Abstract][Full Text] [Related]
16. Role of MicroRNA-155 in Triptolide-induced hepatotoxicity via the Nrf2-Dependent pathway.
Li Y; Guo L; Hou Z; Gong H; Yan M; Zhang B
J Ethnopharmacol; 2021 Dec; 281():114489. PubMed ID: 34363931
[TBL] [Abstract][Full Text] [Related]
17. Effects of cytochrome P4503A inducer dexamethasone on the metabolism and toxicity of triptolide in rat.
Ye X; Li W; Yan Y; Mao C; Cai R; Xu H; Yang X
Toxicol Lett; 2010 Feb; 192(2):212-20. PubMed ID: 19879934
[TBL] [Abstract][Full Text] [Related]
18. Knockout of hepatic P450 reductase aggravates triptolide-induced toxicity.
Xue X; Gong L; Qi X; Wu Y; Xing G; Yao J; Luan Y; Xiao Y; Li Y; Wu X; Chen M; Gu J; Ren J
Toxicol Lett; 2011 Aug; 205(1):47-54. PubMed ID: 21596114
[TBL] [Abstract][Full Text] [Related]
19. Effect of CYP3A4 on liver injury induced by triptolide.
Xiao X; Zhang T; Huang J; Zhao Q; Li F
Biomed Chromatogr; 2020 Aug; 34(8):e4864. PubMed ID: 32330997
[TBL] [Abstract][Full Text] [Related]
20. High-content analysis boosts identification of the initial cause of triptolide-induced hepatotoxicity.
Zheng N; Wang T; Wei A; Chen W; Zhao C; Li H; Wang L
J Appl Toxicol; 2019 Sep; 39(9):1337-1347. PubMed ID: 31218727
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]