BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

541 related articles for article (PubMed ID: 33613545)

  • 1. Alzheimer's Risk Gene TREM2 Determines Functional Properties of New Type of Human iPSC-Derived Microglia.
    Reich M; Paris I; Ebeling M; Dahm N; Schweitzer C; Reinhardt D; Schmucki R; Prasad M; Köchl F; Leist M; Cowley SA; Zhang JD; Patsch C; Gutbier S; Britschgi M
    Front Immunol; 2020; 11():617860. PubMed ID: 33613545
    [TBL] [Abstract][Full Text] [Related]  

  • 2. TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia.
    Jairaman A; McQuade A; Granzotto A; Kang YJ; Chadarevian JP; Gandhi S; Parker I; Smith I; Cho H; Sensi SL; Othy S; Blurton-Jones M; Cahalan MD
    Elife; 2022 Feb; 11():. PubMed ID: 35191835
    [TBL] [Abstract][Full Text] [Related]  

  • 3. TREM2 Alzheimer's variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages.
    Hall-Roberts H; Agarwal D; Obst J; Smith TB; Monzón-Sandoval J; Di Daniel E; Webber C; James WS; Mead E; Davis JB; Cowley SA
    Alzheimers Res Ther; 2020 Nov; 12(1):151. PubMed ID: 33198789
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC-derived microglia.
    Piers TM; Cosker K; Mallach A; Johnson GT; Guerreiro R; Hardy J; Pocock JM
    FASEB J; 2020 Feb; 34(2):2436-2450. PubMed ID: 31907987
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Reduced TREM2 activation in microglia of patients with Alzheimer's disease.
    Okuzono Y; Sakuma H; Miyakawa S; Ifuku M; Lee J; Das D; Banerjee A; Zhao Y; Yamamoto K; Ando T; Sato S
    FEBS Open Bio; 2021 Nov; 11(11):3063-3080. PubMed ID: 34523252
    [TBL] [Abstract][Full Text] [Related]  

  • 6. iPSC-derived microglia carrying the TREM2 R47H/+ mutation are proinflammatory and promote synapse loss.
    Penney J; Ralvenius WT; Loon A; Cerit O; Dileep V; Milo B; Pao PC; Woolf H; Tsai LH
    Glia; 2024 Feb; 72(2):452-469. PubMed ID: 37969043
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Alzheimer's disease-associated R47H TREM2 increases, but wild-type TREM2 decreases, microglial phagocytosis of synaptosomes and neuronal loss.
    Popescu AS; Butler CA; Allendorf DH; Piers TM; Mallach A; Roewe J; Reinhardt P; Cinti A; Redaelli L; Boudesco C; Pradier L; Pocock JM; Thornton P; Brown GC
    Glia; 2023 Apr; 71(4):974-990. PubMed ID: 36480007
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease.
    McQuade A; Kang YJ; Hasselmann J; Jairaman A; Sotelo A; Coburn M; Shabestari SK; Chadarevian JP; Fote G; Tu CH; Danhash E; Silva J; Martinez E; Cotman C; Prieto GA; Thompson LM; Steffan JS; Smith I; Davtyan H; Cahalan M; Cho H; Blurton-Jones M
    Nat Commun; 2020 Oct; 11(1):5370. PubMed ID: 33097708
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Alzheimer's-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia.
    Andreone BJ; Przybyla L; Llapashtica C; Rana A; Davis SS; van Lengerich B; Lin K; Shi J; Mei Y; Astarita G; Di Paolo G; Sandmann T; Monroe KM; Lewcock JW
    Nat Neurosci; 2020 Aug; 23(8):927-938. PubMed ID: 32514138
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans.
    Xiang X; Piers TM; Wefers B; Zhu K; Mallach A; Brunner B; Kleinberger G; Song W; Colonna M; Herms J; Wurst W; Pocock JM; Haass C
    Mol Neurodegener; 2018 Sep; 13(1):49. PubMed ID: 30185230
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer's disease.
    Vandermeulen L; Geric I; Fumagalli L; Kreir M; Lu A; Nonneman A; Premereur J; Wolfs L; Policarpo R; Fattorelli N; De Bondt A; Van Den Wyngaert I; Asselbergh B; Fiers M; De Strooper B; d'Ydewalle C; Mancuso R
    Mol Neurodegener; 2024 Apr; 19(1):37. PubMed ID: 38654375
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis.
    Garcia-Reitboeck P; Phillips A; Piers TM; Villegas-Llerena C; Butler M; Mallach A; Rodrigues C; Arber CE; Heslegrave A; Zetterberg H; Neumann H; Neame S; Houlden H; Hardy J; Pocock JM
    Cell Rep; 2018 Aug; 24(9):2300-2311. PubMed ID: 30157425
    [TBL] [Abstract][Full Text] [Related]  

  • 13. LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions.
    Zhao P; Xu Y; Jiang LL; Fan X; Ku Z; Li L; Liu X; Deng M; Arase H; Zhu JJ; Huang TY; Zhao Y; Zhang C; Xu H; Tong Q; Zhang N; An Z
    Mol Neurodegener; 2022 Jun; 17(1):44. PubMed ID: 35717259
    [TBL] [Abstract][Full Text] [Related]  

  • 14. IPSC-Derived Neuronal Cultures Carrying the Alzheimer's Disease Associated
    Martins S; Müller-Schiffmann A; Erichsen L; Bohndorf M; Wruck W; Sleegers K; Van Broeckhoven C; Korth C; Adjaye J
    Int J Mol Sci; 2020 Jun; 21(12):. PubMed ID: 32630447
    [TBL] [Abstract][Full Text] [Related]  

  • 15. TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway.
    Zheng H; Jia L; Liu CC; Rong Z; Zhong L; Yang L; Chen XF; Fryer JD; Wang X; Zhang YW; Xu H; Bu G
    J Neurosci; 2017 Feb; 37(7):1772-1784. PubMed ID: 28077724
    [TBL] [Abstract][Full Text] [Related]  

  • 16. TREM2, microglia, and Alzheimer's disease.
    Qin Q; Teng Z; Liu C; Li Q; Yin Y; Tang Y
    Mech Ageing Dev; 2021 Apr; 195():111438. PubMed ID: 33516818
    [TBL] [Abstract][Full Text] [Related]  

  • 17. TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge.
    Nugent AA; Lin K; van Lengerich B; Lianoglou S; Przybyla L; Davis SS; Llapashtica C; Wang J; Kim DJ; Xia D; Lucas A; Baskaran S; Haddick PCG; Lenser M; Earr TK; Shi J; Dugas JC; Andreone BJ; Logan T; Solanoy HO; Chen H; Srivastava A; Poda SB; Sanchez PE; Watts RJ; Sandmann T; Astarita G; Lewcock JW; Monroe KM; Di Paolo G
    Neuron; 2020 Mar; 105(5):837-854.e9. PubMed ID: 31902528
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Imbalance of Microglial TLR4/TREM2 in LPS-Treated APP/PS1 Transgenic Mice: A Potential Link Between Alzheimer's Disease and Systemic Inflammation.
    Zhou J; Yu W; Zhang M; Tian X; Li Y; Lü Y
    Neurochem Res; 2019 May; 44(5):1138-1151. PubMed ID: 30756214
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Microglial signalling pathway deficits associated with the patient derived R47H TREM2 variants linked to AD indicate inability to activate inflammasome.
    Cosker K; Mallach A; Limaye J; Piers TM; Staddon J; Neame SJ; Hardy J; Pocock JM
    Sci Rep; 2021 Jun; 11(1):13316. PubMed ID: 34172778
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The Triggering Receptor Expressed on Myeloid Cells-2 (TREM-2) as Expression of the Relationship between Microglia and Alzheimer's Disease: A Novel Marker for a Promising Pathway to Explore.
    Gussago C; Casati M; Ferri E; Arosio B
    J Frailty Aging; 2019; 8(2):54-56. PubMed ID: 30997915
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 28.