BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

172 related articles for article (PubMed ID: 33614910)

  • 1. Structure-based virtual screening identifies an 8-hydroxyquinoline as a small molecule GLI1 inhibitor.
    Dash RC; Wen J; Zaino AM; Morel SR; Chau LQ; Wechsler-Reya RJ; Hadden MK
    Mol Ther Oncolytics; 2021 Mar; 20():265-276. PubMed ID: 33614910
    [TBL] [Abstract][Full Text] [Related]  

  • 2. 8-Hydroxyquinoline derivatives suppress GLI1-mediated transcription through multiple mechanisms.
    Wen J; Charan Dash R; Zaino AM; Harrahill NJ; Calhoun JT; Dusek CO; Morel SR; Russolillo M; Kyle Hadden M
    Bioorg Chem; 2023 Mar; 132():106387. PubMed ID: 36724660
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Mode and specificity of binding of the small molecule GANT61 to GLI determines inhibition of GLI-DNA binding.
    Agyeman A; Jha BK; Mazumdar T; Houghton JA
    Oncotarget; 2014 Jun; 5(12):4492-503. PubMed ID: 24962990
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Targeting GLI1 and GLI2 with small molecule inhibitors to suppress GLI-dependent transcription and tumor growth.
    Maresca L; Crivaro E; Migliorini F; Anichini G; Giammona A; Pepe S; Poggialini F; Vagaggini C; Giannini G; Sestini S; Borgognoni L; Lapucci A; Dreassi E; Taddei M; Manetti F; Petricci E; Stecca B
    Pharmacol Res; 2023 Sep; 195():106858. PubMed ID: 37473878
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer.
    Mazumdar T; DeVecchio J; Agyeman A; Shi T; Houghton JA
    Oncotarget; 2011 Aug; 2(8):638-45. PubMed ID: 21860067
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synergism between Hedgehog-GLI and EGFR signaling in Hedgehog-responsive human medulloblastoma cells induces downregulation of canonical Hedgehog-target genes and stabilized expression of GLI1.
    Götschel F; Berg D; Gruber W; Bender C; Eberl M; Friedel M; Sonntag J; Rüngeler E; Hache H; Wierling C; Nietfeld W; Lehrach H; Frischauf A; Schwartz-Albiez R; Aberger F; Korf U
    PLoS One; 2013; 8(6):e65403. PubMed ID: 23762360
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Inhibition of p70S6K2 down-regulates Hedgehog/GLI pathway in non-small cell lung cancer cell lines.
    Mizuarai S; Kawagishi A; Kotani H
    Mol Cancer; 2009 Jul; 8():44. PubMed ID: 19575820
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Blocking Hedgehog survival signaling at the level of the GLI genes induces DNA damage and extensive cell death in human colon carcinoma cells.
    Mazumdar T; Devecchio J; Agyeman A; Shi T; Houghton JA
    Cancer Res; 2011 Sep; 71(17):5904-14. PubMed ID: 21747117
    [TBL] [Abstract][Full Text] [Related]  

  • 9. β-arrestin1-mediated acetylation of Gli1 regulates Hedgehog/Gli signaling and modulates self-renewal of SHH medulloblastoma cancer stem cells.
    Miele E; Po A; Begalli F; Antonucci L; Mastronuzzi A; Marras CE; Carai A; Cucchi D; Abballe L; Besharat ZM; Catanzaro G; Infante P; Di Marcotullio L; Canettieri G; De Smaele E; Screpanti I; Locatelli F; Ferretti E
    BMC Cancer; 2017 Jul; 17(1):488. PubMed ID: 28716052
    [TBL] [Abstract][Full Text] [Related]  

  • 10. MEKK2 and MEKK3 suppress Hedgehog pathway-dependent medulloblastoma by inhibiting GLI1 function.
    Lu J; Liu L; Zheng M; Li X; Wu A; Wu Q; Liao C; Zou J; Song H
    Oncogene; 2018 Jul; 37(28):3864-3878. PubMed ID: 29662197
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway.
    Beauchamp EM; Ringer L; Bulut G; Sajwan KP; Hall MD; Lee YC; Peaceman D; Ozdemirli M; Rodriguez O; Macdonald TJ; Albanese C; Toretsky JA; Uren A
    J Clin Invest; 2011 Jan; 121(1):148-60. PubMed ID: 21183792
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Targeting GLI by GANT61 involves mechanisms dependent on inhibition of both transcription and DNA licensing.
    Zhang R; Wu J; Ferrandon S; Glowacki KJ; Houghton JA
    Oncotarget; 2016 Dec; 7(49):80190-80207. PubMed ID: 27863397
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Targeting the GLI family of transcription factors for the development of anti-cancer drugs.
    Dusek CO; Hadden MK
    Expert Opin Drug Discov; 2021 Mar; 16(3):289-302. PubMed ID: 33006903
    [TBL] [Abstract][Full Text] [Related]  

  • 14. RNA editing of the GLI1 transcription factor modulates the output of Hedgehog signaling.
    Shimokawa T; Rahman MF; Tostar U; Sonkoly E; Ståhle M; Pivarcsi A; Palaniswamy R; Zaphiropoulos PG
    RNA Biol; 2013 Feb; 10(2):321-33. PubMed ID: 23324600
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Inhibition of the CyclinD1 promoter in response to sonic hedgehog signaling pathway transduction is mediated by Gli1.
    Lin Z; Sheng H; You C; Cai M; Zhang Y; Yu LS; Yu X; Lin J; Zhang N
    Exp Ther Med; 2017 Jan; 13(1):307-314. PubMed ID: 28123507
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Regulation of DNA damage following termination of Hedgehog (HH) survival signaling at the level of the GLI genes in human colon cancer.
    Agyeman A; Mazumdar T; Houghton JA
    Oncotarget; 2012 Aug; 3(8):854-68. PubMed ID: 23097684
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Role of Glioma-associated GLI1 Oncogene in Carcinogenesis and Cancertargeted Therapy.
    Wu J; Di D; Zhao C; Liu Y; Chen H; Gong Y; Zhao X; Chen H
    Curr Cancer Drug Targets; 2018; 18(6):558-566. PubMed ID: 29189160
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Targeting non-canonical activation of GLI1 by the SOX2-BRD4 transcriptional complex improves the efficacy of HEDGEHOG pathway inhibition in melanoma.
    Pietrobono S; Gaudio E; Gagliardi S; Zitani M; Carrassa L; Migliorini F; Petricci E; Manetti F; Makukhin N; Bond AG; Paradise BD; Ciulli A; Fernandez-Zapico ME; Bertoni F; Stecca B
    Oncogene; 2021 Jun; 40(22):3799-3814. PubMed ID: 33958721
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The bromodomain inhibitor IBET-151 attenuates vismodegib-resistant esophageal adenocarcinoma growth through reduction of GLI signaling.
    Alvarez-Trotta A; Wang Z; Shersher E; Li B; Long J; Lohse I; Wahlestedt C; El-Rifai W; Robbins DJ; Capobianco AJ
    Oncotarget; 2020 Aug; 11(33):3174-3187. PubMed ID: 32913560
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Metformin alleviates hyperglycemia-induced endothelial impairment by downregulating autophagy via the Hedgehog pathway.
    Niu C; Chen Z; Kim KT; Sun J; Xue M; Chen G; Li S; Shen Y; Zhu Z; Wang X; Liang J; Jiang C; Cong W; Jin L; Li X
    Autophagy; 2019 May; 15(5):843-870. PubMed ID: 30653446
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.