These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

211 related articles for article (PubMed ID: 33645214)

  • 1. Thermodynamic Stability and Aggregation Kinetics of EF Helix and EF Loop Variants of Transthyretin.
    Ferguson JA; Sun X; Dyson HJ; Wright PE
    Biochemistry; 2021 Mar; 60(10):756-764. PubMed ID: 33645214
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Conformational Dynamics of an Amyloidogenic Intermediate of Transthyretin: Implications for Structural Remodeling and Amyloid Formation.
    Leach BI; Ferguson JA; Morgan G; Sun X; Kroon G; Oyen D; Dyson HJ; Wright PE
    J Mol Biol; 2024 Aug; 436(16):168673. PubMed ID: 38909653
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Disease-associated mutations impacting BC-loop flexibility trigger long-range transthyretin tetramer destabilization and aggregation.
    Esperante SA; Varejāo N; Pinheiro F; Sant'Anna R; Luque-Ortega JR; Alfonso C; Sora V; Papaleo E; Rivas G; Reverter D; Ventura S
    J Biol Chem; 2021 Sep; 297(3):101039. PubMed ID: 34343569
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Evaluating the effect of mutations and ligand binding on transthyretin homotetramer dynamics.
    Saldaño TE; Zanotti G; Parisi G; Fernandez-Alberti S
    PLoS One; 2017; 12(7):e0181019. PubMed ID: 28704493
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Mispacking of the F87 sidechain drives aggregation-promoting conformational fluctuations in the subunit interfaces of the transthyretin tetramer.
    Sun X; Ferguson JA; Yang K; Stanfield RL; Dyson HJ; Wright PE
    Protein Sci; 2024 Sep; 33(9):e5101. PubMed ID: 39149996
    [TBL] [Abstract][Full Text] [Related]  

  • 6. R104H may suppress transthyretin amyloidogenesis by thermodynamic stabilization, but not by the kinetic mechanism characterizing T119 interallelic trans-suppression.
    Sekijima Y; Dendle MT; Wiseman RL; White JT; D'Haeze W; Kelly JW
    Amyloid; 2006 Jun; 13(2):57-66. PubMed ID: 16911959
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A transthyretin monomer intermediate undergoes local unfolding and transient interaction with oligomers in a kinetically concerted aggregation pathway.
    Sun X; Ferguson JA; Dyson HJ; Wright PE
    J Biol Chem; 2022 Aug; 298(8):102162. PubMed ID: 35724960
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structural insight into pH-induced conformational changes within the native human transthyretin tetramer.
    Palaninathan SK; Mohamedmohaideen NN; Snee WC; Kelly JW; Sacchettini JC
    J Mol Biol; 2008 Oct; 382(5):1157-67. PubMed ID: 18662699
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Hydrogen bonds connecting the N-terminal region and the DE loop stabilize the monomeric structure of transthyretin.
    Inada Y; Ono Y; Okazaki K; Yamashita T; Kawaguchi T; Kawano S; Kobashigawa Y; Shinya S; Kojima C; Shuto T; Kai H; Morioka H; Sato T
    J Biochem; 2023 Sep; 174(4):355-370. PubMed ID: 37400978
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Kinetic analysis of the multistep aggregation pathway of human transthyretin.
    Sun X; Dyson HJ; Wright PE
    Proc Natl Acad Sci U S A; 2018 Jul; 115(27):E6201-E6208. PubMed ID: 29915031
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Dissecting the structure, thermodynamic stability, and aggregation properties of the A25T transthyretin (A25T-TTR) variant involved in leptomeningeal amyloidosis: identifying protein partners that co-aggregate during A25T-TTR fibrillogenesis in cerebrospinal fluid.
    Azevedo EP; Pereira HM; Garratt RC; Kelly JW; Foguel D; Palhano FL
    Biochemistry; 2011 Dec; 50(51):11070-83. PubMed ID: 22091638
    [TBL] [Abstract][Full Text] [Related]  

  • 12. NMR Measurements Reveal the Structural Basis of Transthyretin Destabilization by Pathogenic Mutations.
    Leach BI; Zhang X; Kelly JW; Dyson HJ; Wright PE
    Biochemistry; 2018 Jul; 57(30):4421-4430. PubMed ID: 29972637
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The importance of a gatekeeper residue on the aggregation of transthyretin: implications for transthyretin-related amyloidoses.
    Sant'Anna R; Braga C; Varejão N; Pimenta KM; Graña-Montes R; Alves A; Cortines J; Cordeiro Y; Ventura S; Foguel D
    J Biol Chem; 2014 Oct; 289(41):28324-37. PubMed ID: 25086037
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Comparison of lethal and nonlethal transthyretin variants and their relationship to amyloid disease.
    McCutchen SL; Lai Z; Miroy GJ; Kelly JW; Colón W
    Biochemistry; 1995 Oct; 34(41):13527-36. PubMed ID: 7577941
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Potentially amyloidogenic conformational intermediates populate the unfolding landscape of transthyretin: insights from molecular dynamics simulations.
    Rodrigues JR; Simões CJ; Silva CG; Brito RM
    Protein Sci; 2010 Feb; 19(2):202-19. PubMed ID: 19937650
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Characterization of the transthyretin acid denaturation pathways by analytical ultracentrifugation: implications for wild-type, V30M, and L55P amyloid fibril formation.
    Lashuel HA; Lai Z; Kelly JW
    Biochemistry; 1998 Dec; 37(51):17851-64. PubMed ID: 9922152
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Uncovering the Mechanism of Aggregation of Human Transthyretin.
    Saelices L; Johnson LM; Liang WY; Sawaya MR; Cascio D; Ruchala P; Whitelegge J; Jiang L; Riek R; Eisenberg DS
    J Biol Chem; 2015 Nov; 290(48):28932-43. PubMed ID: 26459562
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A New Folding Kinetic Mechanism for Human Transthyretin and the Influence of the Amyloidogenic V30M Mutation.
    Jesus CS; Almeida ZL; Vaz DC; Faria TQ; Brito RM
    Int J Mol Sci; 2016 Aug; 17(9):. PubMed ID: 27589730
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Transthyretin variants with improved inhibition of β-amyloid aggregation.
    Mangrolia P; Yang DT; Murphy RM
    Protein Eng Des Sel; 2016 Jun; 29(6):209-218. PubMed ID: 27099354
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Transthyretin as both a sensor and a scavenger of β-amyloid oligomers.
    Yang DT; Joshi G; Cho PY; Johnson JA; Murphy RM
    Biochemistry; 2013 Apr; 52(17):2849-61. PubMed ID: 23570378
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.