BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

172 related articles for article (PubMed ID: 33653381)

  • 1. Identification of a potent antagonist of smoothened in hedgehog signaling.
    Fan J; Li H; Kuang L; Zhao Z; He W; Liu C; Wang Y; Cheng SY; Chen W
    Cell Biosci; 2021 Mar; 11(1):46. PubMed ID: 33653381
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A Potent Antagonist of Smoothened in Hedgehog Signaling for Epilepsy.
    Fan J; Zhao Z; Liu R; Li H; He W; Wu J; Wang Y; Chen W
    Int J Mol Sci; 2022 Nov; 23(23):. PubMed ID: 36498832
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Novel-smoothened inhibitors for therapeutic targeting of naïve and drug-resistant hedgehog pathway-driven cancers.
    Li QR; Zhao H; Zhang XS; Lang H; Yu K
    Acta Pharmacol Sin; 2019 Feb; 40(2):257-267. PubMed ID: 29777201
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling.
    Wang J; Mook RA; Lu J; Gooden DM; Ribeiro A; Guo A; Barak LS; Lyerly HK; Chen W
    Bioorg Med Chem; 2012 Nov; 20(22):6751-7. PubMed ID: 23063522
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Biochemical characterization of smoothened receptor antagonists by binding kinetics against drug-resistant mutant.
    Shimizu Y; Ishii T; Ogawa K; Sasaki S; Matsui H; Nakayama M
    Eur J Pharmacol; 2015 Oct; 764():220-227. PubMed ID: 26048307
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Targeting the Oncoprotein Smoothened by Small Molecules: Focus on Novel Acylguanidine Derivatives as Potent Smoothened Inhibitors.
    Pietrobono S; Stecca B
    Cells; 2018 Dec; 7(12):. PubMed ID: 30558232
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Inhibition mechanism exploration of investigational drug TAK-441 as inhibitor against Vismodegib-resistant Smoothened mutant.
    Ishii T; Shimizu Y; Nakashima K; Kondo S; Ogawa K; Sasaki S; Matsui H
    Eur J Pharmacol; 2014 Jan; 723():305-13. PubMed ID: 24291104
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The intrahepatic signalling niche of hedgehog is defined by primary cilia positive cells during chronic liver injury.
    Grzelak CA; Martelotto LG; Sigglekow ND; Patkunanathan B; Ajami K; Calabro SR; Dwyer BJ; Tirnitz-Parker JE; Watkins DN; Warner FJ; Shackel NA; McCaughan GW
    J Hepatol; 2014 Jan; 60(1):143-51. PubMed ID: 23978713
    [TBL] [Abstract][Full Text] [Related]  

  • 9. In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors.
    Benvenuto M; Masuelli L; De Smaele E; Fantini M; Mattera R; Cucchi D; Bonanno E; Di Stefano E; Frajese GV; Orlandi A; Screpanti I; Gulino A; Modesti A; Bei R
    Oncotarget; 2016 Feb; 7(8):9250-70. PubMed ID: 26843616
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Targeting of the Hedgehog signal transduction pathway suppresses survival of malignant pleural mesothelioma cells in vitro.
    You M; Varona-Santos J; Singh S; Robbins DJ; Savaraj N; Nguyen DM
    J Thorac Cardiovasc Surg; 2014 Jan; 147(1):508-16. PubMed ID: 24094913
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors.
    Rimkus TK; Carpenter RL; Qasem S; Chan M; Lo HW
    Cancers (Basel); 2016 Feb; 8(2):. PubMed ID: 26891329
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Ciliary smoothened-mediated noncanonical hedgehog signaling promotes tubulin acetylation.
    Lee H; Ko HW
    Biochem Biophys Res Commun; 2016 Nov; 480(4):574-579. PubMed ID: 27793670
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Prostaglandin E1 Inhibits
    Wu F; Zhang C; Zhao C; Wu H; Teng Z; Jiang T; Wang Y
    Cancer Res; 2020 Jul; 80(13):2818-2832. PubMed ID: 32371475
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Intraflagellar transport 27 is essential for hedgehog signaling but dispensable for ciliogenesis during hair follicle morphogenesis.
    Yang N; Li L; Eguether T; Sundberg JP; Pazour GJ; Chen J
    Development; 2015 Jun; 142(12):2194-202. PubMed ID: 26023097
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Molecular modeling study on resistance of WT/D473H SMO to antagonists LDE-225 and LEQ-506.
    Tu J; Li JJ; Song LT; Zhai HL; Wang J; Zhang XY
    Pharmacol Res; 2018 Mar; 129():491-499. PubMed ID: 29175550
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Smoothened is a poor prognosis factor and a potential therapeutic target in glioma.
    Tu Y; Niu M; Xie P; Yue C; Liu N; Qi Z; Gao S; Liu H; Shi Q; Yu R; Liu X
    Sci Rep; 2017 Feb; 7():42630. PubMed ID: 28195165
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The presence of primary cilia in cancer cells does not predict responsiveness to modulation of smoothened activity.
    Spann AL; Yuan K; Goliwas KF; Steg AD; Kaushik DD; Kwon YJ; Frost AR
    Int J Oncol; 2015 Jul; 47(1):269-79. PubMed ID: 25997440
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Discovery of Hedgehog Antagonists for Cancer Therapy.
    Khatra H; Bose C; Sinha S
    Curr Med Chem; 2017; 24(19):2033-2058. PubMed ID: 28302010
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Targeting GLI factors to inhibit the Hedgehog pathway.
    Infante P; Alfonsi R; Botta B; Mori M; Di Marcotullio L
    Trends Pharmacol Sci; 2015 Aug; 36(8):547-58. PubMed ID: 26072120
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Identification and mechanism of action of the acylguanidine MRT-83, a novel potent Smoothened antagonist.
    Roudaut H; Traiffort E; Gorojankina T; Vincent L; Faure H; Schoenfelder A; Mann A; Manetti F; Solinas A; Taddei M; Ruat M
    Mol Pharmacol; 2011 Mar; 79(3):453-60. PubMed ID: 21177415
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.