BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

134 related articles for article (PubMed ID: 33659387)

  • 1. Karyopherin-β2 Inhibits and Reverses Aggregation and Liquid-liquid Phase Separation of the ALS/FTD-Associated Protein FUS.
    Robinson E; Shorter J; Guo L
    Bio Protoc; 2020 Aug; 10(16):e3725. PubMed ID: 33659387
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation.
    Hofweber M; Hutten S; Bourgeois B; Spreitzer E; Niedner-Boblenz A; Schifferer M; Ruepp MD; Simons M; Niessing D; Madl T; Dormann D
    Cell; 2018 Apr; 173(3):706-719.e13. PubMed ID: 29677514
    [TBL] [Abstract][Full Text] [Related]  

  • 3. A minimal construct of nuclear-import receptor Karyopherin-β2 defines the regions critical for chaperone and disaggregation activity.
    Fare CM; Rhine K; Lam A; Myong S; Shorter J
    J Biol Chem; 2023 Feb; 299(2):102806. PubMed ID: 36529289
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Loss of Dynamic RNA Interaction and Aberrant Phase Separation Induced by Two Distinct Types of ALS/FTD-Linked FUS Mutations.
    Niaki AG; Sarkar J; Cai X; Rhine K; Vidaurre V; Guy B; Hurst M; Lee JC; Koh HR; Guo L; Fare CM; Shorter J; Myong S
    Mol Cell; 2020 Jan; 77(1):82-94.e4. PubMed ID: 31630970
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites.
    Yoshizawa T; Ali R; Jiou J; Fung HYJ; Burke KA; Kim SJ; Lin Y; Peeples WB; Saltzberg D; Soniat M; Baumhardt JM; Oldenbourg R; Sali A; Fawzi NL; Rosen MK; Chook YM
    Cell; 2018 Apr; 173(3):693-705.e22. PubMed ID: 29677513
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Liquid-Liquid Phase Separation of TDP-43 and FUS in Physiology and Pathology of Neurodegenerative Diseases.
    Carey JL; Guo L
    Front Mol Biosci; 2022; 9():826719. PubMed ID: 35187086
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Effect of nuclear import receptors on liquid-liquid phase separation.
    Yoshizawa T; Matsumura H
    Biophys Physicobiol; 2020; 17():25-29. PubMed ID: 33110735
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Regulating Phase Transition in Neurodegenerative Diseases by Nuclear Import Receptors.
    Girdhar A; Guo L
    Biology (Basel); 2022 Jul; 11(7):. PubMed ID: 36101390
    [TBL] [Abstract][Full Text] [Related]  

  • 9. ALS-linked FUS mutations dysregulate G-quadruplex-dependent liquid-liquid phase separation and liquid-to-solid transition.
    Ishiguro A; Lu J; Ozawa D; Nagai Y; Ishihama A
    J Biol Chem; 2021 Nov; 297(5):101284. PubMed ID: 34624313
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structural and energetic basis of ALS-causing mutations in the atypical proline-tyrosine nuclear localization signal of the Fused in Sarcoma protein (FUS).
    Zhang ZC; Chook YM
    Proc Natl Acad Sci U S A; 2012 Jul; 109(30):12017-21. PubMed ID: 22778397
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Therapeutic Dissolution of Aberrant Phases by Nuclear-Import Receptors.
    Guo L; Fare CM; Shorter J
    Trends Cell Biol; 2019 Apr; 29(4):308-322. PubMed ID: 30660504
    [TBL] [Abstract][Full Text] [Related]  

  • 12. ATP enhances at low concentrations but dissolves at high concentrations liquid-liquid phase separation (LLPS) of ALS/FTD-causing FUS.
    Kang J; Lim L; Song J
    Biochem Biophys Res Commun; 2018 Oct; 504(2):545-551. PubMed ID: 30205960
    [TBL] [Abstract][Full Text] [Related]  

  • 13. R521C and R521H mutations in FUS result in weak binding with Karyopherinβ2 leading to Amyotrophic lateral sclerosis: a molecular docking and dynamics study.
    Swetha RG; Ramaiah S; Anbarasu A
    J Biomol Struct Dyn; 2017 Aug; 35(10):2169-2185. PubMed ID: 27381509
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The nucleoporin Nup98 is a site for GDP/GTP exchange on ran and termination of karyopherin beta 2-mediated nuclear import.
    Fontoura BM; Blobel G; Yaseen NR
    J Biol Chem; 2000 Oct; 275(40):31289-96. PubMed ID: 10875935
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Engineered protein disaggregases mitigate toxicity of aberrant prion-like fusion proteins underlying sarcoma.
    Ryan JJ; Sprunger ML; Holthaus K; Shorter J; Jackrel ME
    J Biol Chem; 2019 Jul; 294(29):11286-11296. PubMed ID: 31171724
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Ubiquilin 2 modulates ALS/FTD-linked FUS-RNA complex dynamics and stress granule formation.
    Alexander EJ; Ghanbari Niaki A; Zhang T; Sarkar J; Liu Y; Nirujogi RS; Pandey A; Myong S; Wang J
    Proc Natl Acad Sci U S A; 2018 Dec; 115(49):E11485-E11494. PubMed ID: 30442662
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The RNA-binding protein FUS is chaperoned and imported into the nucleus by a network of import receptors.
    Baade I; Hutten S; Sternburg EL; Pörschke M; Hofweber M; Dormann D; Kehlenbach RH
    J Biol Chem; 2021; 296():100659. PubMed ID: 33857479
    [TBL] [Abstract][Full Text] [Related]  

  • 18. FUS pathology in ALS is linked to alterations in multiple ALS-associated proteins and rescued by drugs stimulating autophagy.
    Marrone L; Drexler HCA; Wang J; Tripathi P; Distler T; Heisterkamp P; Anderson EN; Kour S; Moraiti A; Maharana S; Bhatnagar R; Belgard TG; Tripathy V; Kalmbach N; Hosseinzadeh Z; Crippa V; Abo-Rady M; Wegner F; Poletti A; Troost D; Aronica E; Busskamp V; Weis J; Pandey UB; Hyman AA; Alberti S; Goswami A; Sterneckert J
    Acta Neuropathol; 2019 Jul; 138(1):67-84. PubMed ID: 30937520
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Crystal structure of human Karyopherin β2 bound to the PY-NLS of Saccharomyces cerevisiae Nab2.
    Soniat M; Sampathkumar P; Collett G; Gizzi AS; Banu RN; Bhosle RC; Chamala S; Chowdhury S; Fiser A; Glenn AS; Hammonds J; Hillerich B; Khafizov K; Love JD; Matikainen B; Seidel RD; Toro R; Rajesh Kumar P; Bonanno JB; Chook YM; Almo SC
    J Struct Funct Genomics; 2013 Jun; 14(2):31-5. PubMed ID: 23535894
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The phase separation-dependent FUS interactome reveals nuclear and cytoplasmic function of liquid-liquid phase separation.
    Reber S; Jutzi D; Lindsay H; Devoy A; Mechtersheimer J; Levone BR; Domanski M; Bentmann E; Dormann D; Mühlemann O; Barabino SML; Ruepp MD
    Nucleic Acids Res; 2021 Jul; 49(13):7713-7731. PubMed ID: 34233002
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.