BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

99 related articles for article (PubMed ID: 33683117)

  • 21. Near infrared imaging of Mer tyrosine kinase (MERTK) using MERi-SiR reveals tumor associated macrophage uptake in metastatic disease.
    Miller MA; Kim E; Cuccarese MF; Plotkin AL; Prytyskach M; Kohler RH; Pittet MJ; Weissleder R
    Chem Commun (Camb); 2017 Dec; 54(1):42-45. PubMed ID: 29185561
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Discovery of Mer kinase inhibitors by virtual screening using Structural Protein-Ligand Interaction Fingerprints.
    Da C; Stashko M; Jayakody C; Wang X; Janzen W; Frye S; Kireev D
    Bioorg Med Chem; 2015 Mar; 23(5):1096-101. PubMed ID: 25638502
    [TBL] [Abstract][Full Text] [Related]  

  • 23. MERTK Promotes Resistance to Irreversible EGFR Tyrosine Kinase Inhibitors in Non-small Cell Lung Cancers Expressing Wild-type
    Yan D; Parker RE; Wang X; Frye SV; Earp HS; DeRyckere D; Graham DK
    Clin Cancer Res; 2018 Dec; 24(24):6523-6535. PubMed ID: 30194074
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Discovery and optimization of pyrrolo[1,2-a]pyrazinones leads to novel and selective inhibitors of PIM kinases.
    Casuscelli F; Ardini E; Avanzi N; Casale E; Cervi G; D'Anello M; Donati D; Faiardi D; Ferguson RD; Fogliatto G; Galvani A; Marsiglio A; Mirizzi DG; Montemartini M; Orrenius C; Papeo G; Piutti C; Salom B; Felder ER
    Bioorg Med Chem; 2013 Dec; 21(23):7364-80. PubMed ID: 24139169
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Discovery and optimization of a series of 2-aminothiazole-oxazoles as potent phosphoinositide 3-kinase γ inhibitors.
    Oka Y; Yabuuchi T; Fujii Y; Ohtake H; Wakahara S; Matsumoto K; Endo M; Tamura Y; Sekiguchi Y
    Bioorg Med Chem Lett; 2012 Dec; 22(24):7534-8. PubMed ID: 23122859
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Discovery and optimization of indazoles as potent and selective interleukin-2 inducible T cell kinase (ITK) inhibitors.
    Pastor RM; Burch JD; Magnuson S; Ortwine DF; Chen Y; De La Torre K; Ding X; Eigenbrot C; Johnson A; Liimatta M; Liu Y; Shia S; Wang X; Wu LC; Pei Z
    Bioorg Med Chem Lett; 2014 Jun; 24(11):2448-52. PubMed ID: 24767842
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Monte Carlo Method Based QSAR Studies of Mer Kinase Inhibitors in Compliance with OECD Principles.
    Kumar P; Kumar A
    Drug Res (Stuttg); 2018 Apr; 68(4):189-195. PubMed ID: 28992659
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Discovery, optimization and biological evaluation for novel c-Met kinase inhibitors.
    Yuan H; Liu Q; Zhang L; Hu S; Chen T; Li H; Chen Y; Xu Y; Lu T
    Eur J Med Chem; 2018 Jan; 143():491-502. PubMed ID: 29202410
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Discovery of 4-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamides as novel, highly potent and selective, orally bioavailable inhibitors of Tyrosine Threonine Kinase, TTK.
    Laufer R; Li SW; Liu Y; Ng G; Lang Y; Feher M; Brokx R; Beletskaya I; Hodgson R; Mao G; Plotnikova O; Awrey DE; Mason JM; Wei X; Lin DC; Che Y; Kiarash R; Madeira B; Fletcher GC; Mak TW; Bray MR; Pauls HW
    Bioorg Med Chem Lett; 2016 Aug; 26(15):3562-6. PubMed ID: 27335255
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Pharmacophore-Based 3D-QSAR Modeling, Virtual Screening and Molecular Docking Analysis for the Detection of MERTK Inhibitors with Novel Scaffold.
    Zhou S; Zhou L; Cui R; Tian Y; Li X; You R; Zhong L
    Comb Chem High Throughput Screen; 2016; 19(1):73-96. PubMed ID: 26632441
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Synthesis, kinase inhibitory potencies, and in vitro antiproliferative evaluation of new Pim kinase inhibitors.
    Akué-Gédu R; Rossignol E; Azzaro S; Knapp S; Filippakopoulos P; Bullock AN; Bain J; Cohen P; Prudhomme M; Anizon F; Moreau P
    J Med Chem; 2009 Oct; 52(20):6369-81. PubMed ID: 19788246
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Developing Antagonists for the Met-HGF/SF Protein-Protein Interaction Using a Fragment-Based Approach.
    Winter A; Sigurdardottir AG; DiCara D; Valenti G; Blundell TL; Gherardi E
    Mol Cancer Ther; 2016 Jan; 15(1):3-14. PubMed ID: 26712116
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Discovery of novel 7-azaindoles as PDK1 inhibitors.
    Wucherer-Plietker M; Merkul E; Müller TJJ; Esdar C; Knöchel T; Heinrich T; Buchstaller HP; Greiner H; Dorsch D; Finsinger D; Calderini M; Bruge D; Grädler U
    Bioorg Med Chem Lett; 2016 Jul; 26(13):3073-3080. PubMed ID: 27217002
    [TBL] [Abstract][Full Text] [Related]  

  • 34. The discovery of novel protein kinase inhibitors by using fragment-based high-throughput x-ray crystallography.
    Gill A; Cleasby A; Jhoti H
    Chembiochem; 2005 Mar; 6(3):506-12. PubMed ID: 15696598
    [TBL] [Abstract][Full Text] [Related]  

  • 35. A crystallographic fragment screen identifies cinnamic acid derivatives as starting points for potent Pim-1 inhibitors.
    Schulz MN; Fanghänel J; Schäfer M; Badock V; Briem H; Boemer U; Nguyen D; Husemann M; Hillig RC
    Acta Crystallogr D Biol Crystallogr; 2011 Mar; 67(Pt 3):156-66. PubMed ID: 21358046
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Identification and characterisation of 2-aminopyridine inhibitors of checkpoint kinase 2.
    Hilton S; Naud S; Caldwell JJ; Boxall K; Burns S; Anderson VE; Antoni L; Allen CE; Pearl LH; Oliver AW; Wynne Aherne G; Garrett MD; Collins I
    Bioorg Med Chem; 2010 Jan; 18(2):707-18. PubMed ID: 20022510
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Identification and optimization of pyridazinones as potent and selective c-Met kinase inhibitors.
    Dorsch D; Schadt O; Stieber F; Meyring M; Grädler U; Bladt F; Friese-Hamim M; Knühl C; Pehl U; Blaukat A
    Bioorg Med Chem Lett; 2015 Apr; 25(7):1597-602. PubMed ID: 25736998
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Discovery and SAR exploration of a novel series of imidazo[4,5-b]pyrazin-2-ones as potent and selective mTOR kinase inhibitors.
    Mortensen DS; Perrin-Ninkovic SM; Harris R; Lee BG; Shevlin G; Hickman M; Khambatta G; Bisonette RR; Fultz KE; Sankar S
    Bioorg Med Chem Lett; 2011 Nov; 21(22):6793-9. PubMed ID: 21978683
    [TBL] [Abstract][Full Text] [Related]  

  • 39. The discovery of potent and selective pyridopyrimidin-7-one based inhibitors of B-RafV600E kinase.
    Ren L; Ahrendt KA; Grina J; Laird ER; Buckmelter AJ; Hansen JD; Newhouse B; Moreno D; Wenglowsky S; Dinkel V; Gloor SL; Hastings G; Rana S; Rasor K; Risom T; Sturgis HL; Voegtli WC; Mathieu S
    Bioorg Med Chem Lett; 2012 May; 22(10):3387-91. PubMed ID: 22534450
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Discovery and characterization of MAPK-activated protein kinase-2 prevention of activation inhibitors.
    Cumming JG; Debreczeni JÉ; Edfeldt F; Evertsson E; Harrison M; Holdgate GA; James MJ; Lamont SG; Oldham K; Sullivan JE; Wells SL
    J Med Chem; 2015 Jan; 58(1):278-93. PubMed ID: 25255283
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 5.