BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

318 related articles for article (PubMed ID: 33712838)

  • 1. Novel Glutamine Antagonist JHU395 Suppresses MYC-Driven Medulloblastoma Growth and Induces Apoptosis.
    Pham K; Maxwell MJ; Sweeney H; Alt J; Rais R; Eberhart CG; Slusher BS; Raabe EH
    J Neuropathol Exp Neurol; 2021 Mar; 80(4):336-344. PubMed ID: 33712838
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Orally bioavailable glutamine antagonist prodrug JHU-083 penetrates mouse brain and suppresses the growth of MYC-driven medulloblastoma.
    Hanaford AR; Alt J; Rais R; Wang SZ; Kaur H; Thorek DLJ; Eberhart CG; Slusher BS; Martin AM; Raabe EH
    Transl Oncol; 2019 Oct; 12(10):1314-1322. PubMed ID: 31340195
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Unbiased Metabolic Profiling Predicts Sensitivity of High MYC-Expressing Atypical Teratoid/Rhabdoid Tumors to Glutamine Inhibition with 6-Diazo-5-Oxo-L-Norleucine.
    Wang SZ; Poore B; Alt J; Price A; Allen SJ; Hanaford AR; Kaur H; Orr BA; Slusher BS; Eberhart CG; Raabe EH; Rubens JA
    Clin Cancer Res; 2019 Oct; 25(19):5925-5936. PubMed ID: 31300448
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Model studies towards prodrugs of the glutamine antagonist 6-diazo-5-oxo-l-norleucine (DON) containing a diazo precursor.
    Gao RD; Hin N; Prchalová E; Pal A; Lam J; Rais R; Slusher BS; Tsukamoto T
    Bioorg Med Chem Lett; 2021 Oct; 50():128321. PubMed ID: 34400301
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Antagonizing Bcl-2 family members sensitizes neuroblastoma and Ewing's sarcoma to an inhibitor of glutamine metabolism.
    Olsen RR; Mary-Sinclair MN; Yin Z; Freeman KW
    PLoS One; 2015; 10(1):e0116998. PubMed ID: 25615615
    [TBL] [Abstract][Full Text] [Related]  

  • 6. N-(Pivaloyloxy)alkoxy-carbonyl Prodrugs of the Glutamine Antagonist 6-Diazo-5-oxo-l-norleucine (DON) as a Potential Treatment for HIV Associated Neurocognitive Disorders.
    Nedelcovych MT; Tenora L; Kim BH; Kelschenbach J; Chao W; Hadas E; Jančařík A; Prchalová E; Zimmermann SC; Dash RP; Gadiano AJ; Garrett C; Furtmüller G; Oh B; Brandacher G; Alt J; Majer P; Volsky DJ; Rais R; Slusher BS
    J Med Chem; 2017 Aug; 60(16):7186-7198. PubMed ID: 28759224
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Discovery of 6-Diazo-5-oxo-l-norleucine (DON) Prodrugs with Enhanced CSF Delivery in Monkeys: A Potential Treatment for Glioblastoma.
    Rais R; Jančařík A; Tenora L; Nedelcovych M; Alt J; Englert J; Rojas C; Le A; Elgogary A; Tan J; Monincová L; Pate K; Adams R; Ferraris D; Powell J; Majer P; Slusher BS
    J Med Chem; 2016 Sep; 59(18):8621-33. PubMed ID: 27560860
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug.
    Rais R; Lemberg KM; Tenora L; Arwood ML; Pal A; Alt J; Wu Y; Lam J; Aguilar JMH; Zhao L; Peters DE; Tallon C; Pandey R; Thomas AG; Dash RP; Seiwert T; Majer P; Leone RD; Powell JD; Slusher BS
    Sci Adv; 2022 Nov; 8(46):eabq5925. PubMed ID: 36383674
    [TBL] [Abstract][Full Text] [Related]  

  • 9. We're Not "DON" Yet: Optimal Dosing and Prodrug Delivery of
    Lemberg KM; Vornov JJ; Rais R; Slusher BS
    Mol Cancer Ther; 2018 Sep; 17(9):1824-1832. PubMed ID: 30181331
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Mechanism of action and therapeutic efficacy of Aurora kinase B inhibition in MYC overexpressing medulloblastoma.
    Diaz RJ; Golbourn B; Faria C; Picard D; Shih D; Raynaud D; Leadly M; MacKenzie D; Bryant M; Bebenek M; Smith CA; Taylor MD; Huang A; Rutka JT
    Oncotarget; 2015 Feb; 6(5):3359-74. PubMed ID: 25739120
    [TBL] [Abstract][Full Text] [Related]  

  • 11. BET bromodomain protein inhibition is a therapeutic option for medulloblastoma.
    Henssen A; Thor T; Odersky A; Heukamp L; El-Hindy N; Beckers A; Speleman F; Althoff K; Schäfers S; Schramm A; Sure U; Fleischhack G; Eggert A; Schulte JH
    Oncotarget; 2013 Nov; 4(11):2080-95. PubMed ID: 24231268
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Protective Effects of Glutamine Antagonist 6-Diazo-5-Oxo-l-Norleucine in Mice with Alphavirus Encephalomyelitis.
    Manivannan S; Baxter VK; Schultz KL; Slusher BS; Griffin DE
    J Virol; 2016 Oct; 90(20):9251-62. PubMed ID: 27489275
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A redox-responsive prodrug for tumor-targeted glutamine restriction.
    Prange CJ; Sayed NYB; Feng B; Goepfert C; Trujillo DO; Hu X; Tang L
    J Control Release; 2024 Apr; 368():251-264. PubMed ID: 38403173
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Tumor-Targeted Delivery of 6-Diazo-5-oxo-l-norleucine (DON) Using Substituted Acetylated Lysine Prodrugs.
    Tenora L; Alt J; Dash RP; Gadiano AJ; Novotná K; Veeravalli V; Lam J; Kirkpatrick QR; Lemberg KM; Majer P; Rais R; Slusher BS
    J Med Chem; 2019 Apr; 62(7):3524-3538. PubMed ID: 30892035
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Glutamine Antagonist JHU083 Normalizes Aberrant Glutamate Production and Cognitive Deficits in the EcoHIV Murine Model of HIV-Associated Neurocognitive Disorders.
    Nedelcovych MT; Kim BH; Zhu X; Lovell LE; Manning AA; Kelschenbach J; Hadas E; Chao W; Prchalová E; Dash RP; Wu Y; Alt J; Thomas AG; Rais R; Kamiya A; Volsky DJ; Slusher BS
    J Neuroimmune Pharmacol; 2019 Sep; 14(3):391-400. PubMed ID: 31209775
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Inhibitory Effect of a Glutamine Antagonist on Proliferation and Migration of VSMCs via Simultaneous Attenuation of Glycolysis and Oxidative Phosphorylation.
    Park HY; Kim MJ; Lee S; Jin J; Lee S; Kim JG; Choi YK; Park KG
    Int J Mol Sci; 2021 May; 22(11):. PubMed ID: 34070527
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Discovery of
    Novotná K; Tenora L; Prchalová E; Paule J; Alt J; Veeravalli V; Lam J; Wu Y; Šnajdr I; Gori S; Mettu VS; Tsukamoto T; Majer P; Slusher BS; Rais R
    J Med Chem; 2023 Nov; 66(22):15493-15510. PubMed ID: 37949450
    [TBL] [Abstract][Full Text] [Related]  

  • 18. TORC1/2 kinase inhibition depletes glutathione and synergizes with carboplatin to suppress the growth of MYC-driven medulloblastoma.
    Maynard RE; Poore B; Hanaford AR; Pham K; James M; Alt J; Park Y; Slusher BS; Tamayo P; Mesirov J; Archer TC; Pomeroy SL; Eberhart CG; Raabe EH
    Cancer Lett; 2021 Apr; 504():137-145. PubMed ID: 33571541
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A Novel Combination Approach Targeting an Enhanced Protein Synthesis Pathway in MYC-driven (Group 3) Medulloblastoma.
    Chaturvedi NK; Kling MJ; Griggs CN; Kesherwani V; Shukla M; McIntyre EM; Ray S; Liu Y; McGuire TR; Sharp JG; Band H; Joshi SS; Coulter DW
    Mol Cancer Ther; 2020 Jun; 19(6):1351-1362. PubMed ID: 32371591
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Influence of 6-diazo-5-oxo-L-norleucine (DON), a glutamine analogue, on cartilaginous differentiation in mouse limb buds in vitro.
    Aydelotte MB; Kochhar DM
    Differentiation; 1975 Oct; 4(2):73-80. PubMed ID: 1183764
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.