BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

196 related articles for article (PubMed ID: 33725632)

  • 1. Design, synthesis, and biological evaluation of nitroisoxazole-containing spiro[pyrrolidin-oxindole] derivatives as novel glutathione peroxidase 4/mouse double minute 2 dual inhibitors that inhibit breast adenocarcinoma cell proliferation.
    Liu SJ; Zhao Q; Peng C; Mao Q; Wu F; Zhang FH; Feng QS; He G; Han B
    Eur J Med Chem; 2021 May; 217():113359. PubMed ID: 33725632
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Molecular hybridization design and synthesis of novel spirooxindole-based MDM2 inhibitors endowed with BCL2 signaling attenuation; a step towards the next generation p53 activators.
    Lotfy G; Abdel Aziz YM; Said MM; El Ashry ESH; El Tamany ESH; Abu-Serie MM; Teleb M; Dömling A; Barakat A
    Bioorg Chem; 2021 Dec; 117():105427. PubMed ID: 34794098
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Synthesis of new thiazolo-pyrrolidine-(spirooxindole) tethered to 3-acylindole as anticancer agents.
    Islam MS; Ghawas HM; El-Senduny FF; Al-Majid AM; Elshaier YAMM; Badria FA; Barakat A
    Bioorg Chem; 2019 Feb; 82():423-430. PubMed ID: 30508794
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Design, synthesis and biological evaluation of novel antitumor spirotetrahydrothiopyran-oxindole derivatives as potent p53-MDM2 inhibitors.
    Ji C; Wang S; Chen S; He S; Jiang Y; Miao Z; Li J; Sheng C
    Bioorg Med Chem; 2017 Oct; 25(20):5268-5277. PubMed ID: 28797774
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Design, Synthesis and Antitumor Activity of Novel Dispiro[oxindole-cyclohexanone]- pyrrolidines.
    Gouda M; Bawazeer M; Hegazy L; Azab M; Elagawany M; Rateb M; Yaseen M; Elgendy B
    Curr Pharm Des; 2022; 28(3):198-207. PubMed ID: 34176458
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Inhibition of p53-Murine Double Minute 2 (MDM2) Interactions with 3,3'-Spirocyclopentene Oxindole Derivatives.
    Gicquel M; Gomez C; Garcia Alvarez MC; Pamlard O; Guérineau V; Jacquet E; Bignon J; Voituriez A; Marinetti A
    J Med Chem; 2018 Oct; 61(20):9386-9392. PubMed ID: 30221935
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Spiro-oxindoles as a Promising Class of Small Molecule Inhibitors of p53-MDM2 Interaction Useful in Targeted Cancer Therapy.
    Gupta AK; Bharadwaj M; Kumar A; Mehrotra R
    Top Curr Chem (Cham); 2017 Feb; 375(1):3. PubMed ID: 27943171
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Spiro-oxindole derivative 5-chloro-4',5'-diphenyl-3'-(4-(2-(piperidin-1-yl) ethoxy) benzoyl) spiro[indoline-3,2'-pyrrolidin]-2-one triggers apoptosis in breast cancer cells via restoration of p53 function.
    Saxena R; Gupta G; Manohar M; Debnath U; Popli P; Prabhakar YS; Konwar R; Kumar S; Kumar A; Dwivedi A
    Int J Biochem Cell Biol; 2016 Jan; 70():105-17. PubMed ID: 26556313
    [TBL] [Abstract][Full Text] [Related]  

  • 9. One-pot synthesis of spiro(indoline-3,4'-pyrazolo[3,4-b]pyridine)-5'-carbonitriles as p53-MDM2 interaction inhibitors.
    Ibrahim HS; Eldehna WM; Fallacara AL; Ahmed ER; Ghabbour HA; Elaasser MM; Botta M; Abou-Seri SM; Abdel-Aziz HA
    Future Med Chem; 2018 Dec; 10(24):2771-2789. PubMed ID: 30526032
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis of Spiro[indole-3,5'-isoxazoles] with Anticancer Activity via a Formal [4 + 1]-Spirocyclization of Nitroalkenes to Indoles.
    Aksenov AV; Aksenov DA; Arutiunov NA; Aksenov NA; Aleksandrova EV; Zhao Z; Du L; Kornienko A; Rubin M
    J Org Chem; 2019 Jun; 84(11):7123-7137. PubMed ID: 31070030
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis of spiro-tetrahydrothiopyran-oxindoles by Michael-aldol cascade reactions: discovery of potential P53-MDM2 inhibitors with good antitumor activity.
    Wang S; Chen S; Guo Z; He S; Zhang F; Liu X; Chen W; Zhang S; Sheng C
    Org Biomol Chem; 2018 Jan; 16(4):625-634. PubMed ID: 29302672
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Organocatalytic Asymmetric Synthesis of Spiro-oxindole Piperidine Derivatives That Reduce Cancer Cell Proliferation by Inhibiting MDM2-p53 Interaction.
    Yang MC; Peng C; Huang H; Yang L; He XH; Huang W; Cui HL; He G; Han B
    Org Lett; 2017 Dec; 19(24):6752-6755. PubMed ID: 29210587
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Stereoselective Synthesis of the Di-Spirooxindole Analogs Based Oxindole and Cyclohexanone Moieties as Potential Anticancer Agents.
    Al-Majid AM; Ali M; Islam MS; Alshahrani S; Alamary AS; Yousuf S; Choudhary MI; Barakat A
    Molecules; 2021 Oct; 26(20):. PubMed ID: 34684885
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Design, synthesis and biological evaluation of novel indanone containing spiroisoxazoline derivatives with selective COX-2 inhibition as anticancer agents.
    Abolhasani H; Zarghi A; Komeili Movahhed T; Abolhasani A; Daraei B; Dastmalchi S
    Bioorg Med Chem; 2021 Feb; 32():115960. PubMed ID: 33477020
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Design of chemically stable, potent, and efficacious MDM2 inhibitors that exploit the retro-mannich ring-opening-cyclization reaction mechanism in spiro-oxindoles.
    Aguilar A; Sun W; Liu L; Lu J; McEachern D; Bernard D; Deschamps JR; Wang S
    J Med Chem; 2014 Dec; 57(24):10486-98. PubMed ID: 25496041
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis of some novel methyl β-orsellinate based 3, 5-disubstituted isoxazoles and their anti-proliferative activity: Identification of potent leads active against MCF-7 breast cancer cell.
    Reddy ST; Mendonza JJ; Makani VKK; Bhadra MP; Uppuluri VM
    Bioorg Chem; 2020 Dec; 105():104374. PubMed ID: 33130349
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Discovery of new LXRβ agonists as glioblastoma inhibitors.
    Chen H; Chen Z; Zhang Z; Li Y; Zhang S; Jiang F; Wei J; Ding P; Zhou H; Gu Q; Xu J
    Eur J Med Chem; 2020 May; 194():112240. PubMed ID: 32248003
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Spiro[pyrrolidine-3, 3´-oxindole] as potent anti-breast cancer compounds: Their design, synthesis, biological evaluation and cellular target identification.
    Hati S; Tripathy S; Dutta PK; Agarwal R; Srinivasan R; Singh A; Singh S; Sen S
    Sci Rep; 2016 Aug; 6():32213. PubMed ID: 27573798
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Design and Synthesis of New
    Farghaly TA; Pashameah RA; Bayazeed A; Al-Soliemy AM; Alsaedi AMR; Harras MF
    Med Chem; 2024; 20(1):63-77. PubMed ID: 37723960
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Design, synthesis, and biological evaluation of imidazoline derivatives as p53-MDM2 binding inhibitors.
    Hu C; Li X; Wang W; Zhang L; Tao L; Dong X; Sheng R; Yang B; Hu Y
    Bioorg Med Chem; 2011 Sep; 19(18):5454-61. PubMed ID: 21855354
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.