162 related articles for article (PubMed ID: 33730678)
1. Ring closure strategy leads to potent RIPK3 inhibitors.
Wu S; Xu C; Xia K; Lin Y; Tian S; Ma H; Ji Y; Zhu F; He S; Zhang X
Eur J Med Chem; 2021 May; 217():113327. PubMed ID: 33730678
[TBL] [Abstract][Full Text] [Related]
2. Identification of the Raf kinase inhibitor TAK-632 and its analogues as potent inhibitors of necroptosis by targeting RIPK1 and RIPK3.
Chen X; Zhuang C; Ren Y; Zhang H; Qin X; Hu L; Fu J; Miao Z; Chai Y; Liu ZG; Zhang H; Cai Z; Wang HY
Br J Pharmacol; 2019 Jun; 176(12):2095-2108. PubMed ID: 30825190
[TBL] [Abstract][Full Text] [Related]
3. Design, synthesis, and evaluation of potent RIPK1 inhibitors with in vivo anti-inflammatory activity.
Li Z; Hao Y; Yang C; Yang Q; Wu S; Ma H; Tian S; Lu H; Wang J; Yang T; He S; Zhang X
Eur J Med Chem; 2022 Jan; 228():114036. PubMed ID: 34906762
[TBL] [Abstract][Full Text] [Related]
4. Discovery of potent necroptosis inhibitors targeting RIPK1 kinase activity for the treatment of inflammatory disorder and cancer metastasis.
Hou J; Ju J; Zhang Z; Zhao C; Li Z; Zheng J; Sheng T; Zhang H; Hu L; Yu X; Zhang W; Li Y; Wu M; Ma H; Zhang X; He S
Cell Death Dis; 2019 Jun; 10(7):493. PubMed ID: 31235688
[TBL] [Abstract][Full Text] [Related]
5.
Zhang H; Xu L; Qin X; Chen X; Cong H; Hu L; Chen L; Miao Z; Zhang W; Cai Z; Zhuang C
J Med Chem; 2019 Jul; 62(14):6665-6681. PubMed ID: 31095385
[TBL] [Abstract][Full Text] [Related]
6. Synthesis and characterization of potent RIPK3 inhibitors based on a tricyclic scaffold.
Wu S; Yang Q; Ji Y; Tian S; Ma H; Du S; Lu H; He S; Zhang X
Future Med Chem; 2022 Mar; 14(6):421-442. PubMed ID: 35167311
[No Abstract] [Full Text] [Related]
7. The Bcr-Abl inhibitor GNF-7 inhibits necroptosis and ameliorates acute kidney injury by targeting RIPK1 and RIPK3 kinases.
Qin X; Hu L; Shi SN; Chen X; Zhuang C; Zhang W; Jitkaew S; Pang X; Yu J; Tan YX; Wang HY; Cai Z
Biochem Pharmacol; 2020 Jul; 177():113947. PubMed ID: 32247850
[TBL] [Abstract][Full Text] [Related]
8. Phenytoin inhibits necroptosis.
von Mässenhausen A; Tonnus W; Himmerkus N; Parmentier S; Saleh D; Rodriguez D; Ousingsawat J; Ang RL; Weinberg JM; Sanz AB; Ortiz A; Zierleyn A; Becker JU; Baratte B; Desban N; Bach S; Schiessl IM; Nogusa S; Balachandran S; Anders HJ; Ting AT; Bleich M; Degterev A; Kunzelmann K; Bornstein SR; Green DR; Hugo C; Linkermann A
Cell Death Dis; 2018 Mar; 9(3):359. PubMed ID: 29500402
[TBL] [Abstract][Full Text] [Related]
9. Discovery, optimization and evaluation of isothiazolo[5,4-b]pyridine derivatives as RIPK1 inhibitors with potent in vivo anti-SIRS activity.
Hao Y; Yang C; Shu C; Li Z; Xia K; Wu S; Ma H; Tian S; Ji Y; Li J; He S; Zhang X
Bioorg Chem; 2022 Dec; 129():106051. PubMed ID: 36115309
[TBL] [Abstract][Full Text] [Related]
10. Scaffold hopping derived novel benzoxazepinone RIPK1 inhibitors as anti-necroptosis agents.
Tang J; Wu Y; Zhao W; Qu Z; Yu J; Wang Z; Shi Y
Bioorg Med Chem; 2023 Aug; 91():117385. PubMed ID: 37364415
[TBL] [Abstract][Full Text] [Related]
11. RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury.
Newton K; Dugger DL; Maltzman A; Greve JM; Hedehus M; Martin-McNulty B; Carano RA; Cao TC; van Bruggen N; Bernstein L; Lee WP; Wu X; DeVoss J; Zhang J; Jeet S; Peng I; McKenzie BS; Roose-Girma M; Caplazi P; Diehl L; Webster JD; Vucic D
Cell Death Differ; 2016 Sep; 23(9):1565-76. PubMed ID: 27177019
[TBL] [Abstract][Full Text] [Related]
12. FKBP12 mediates necroptosis by initiating RIPK1-RIPK3-MLKL signal transduction in response to TNF receptor 1 ligation.
Wang Z; Feng J; Yu J; Chen G
J Cell Sci; 2019 May; 132(10):. PubMed ID: 31028177
[TBL] [Abstract][Full Text] [Related]
13. Identification of 5-(2,3-Dihydro-1 H-indol-5-yl)-7 H-pyrrolo[2,3- d]pyrimidin-4-amine Derivatives as a New Class of Receptor-Interacting Protein Kinase 1 (RIPK1) Inhibitors, Which Showed Potent Activity in a Tumor Metastasis Model.
Li Y; Xiong Y; Zhang G; Zhang L; Yang W; Yang J; Huang L; Qiao Z; Miao Z; Lin G; Sun Q; Niu T; Chen L; Niu D; Li L; Yang S
J Med Chem; 2018 Dec; 61(24):11398-11414. PubMed ID: 30480444
[TBL] [Abstract][Full Text] [Related]
14. Critical contribution of oxidative stress to TNFα-induced necroptosis downstream of RIPK1 activation.
Shindo R; Kakehashi H; Okumura K; Kumagai Y; Nakano H
Biochem Biophys Res Commun; 2013 Jun; 436(2):212-6. PubMed ID: 23727581
[TBL] [Abstract][Full Text] [Related]
15. Discovery of 4-amino-1,6-dihydro-7H-pyrrolo[2,3-d]pyridazin-7-one derivatives as potential receptor-interacting serine/threonine-protein kinase 1 (RIPK1) inhibitors.
Zhang C; Chen Y; Li Y; Shi N; Teng Y; Li N; Tang M; Ma Z; Deng D; Chen L
Eur J Med Chem; 2024 Feb; 265():116076. PubMed ID: 38171150
[TBL] [Abstract][Full Text] [Related]
16. Profiling of the chemical space on the phenyl group of substituted benzothiazole RIPK3 inhibitors.
Xu Y; Liang C; Zhang W; Yu J; Xing C; Liu H; Zhuang C
Bioorg Chem; 2023 Feb; 131():106339. PubMed ID: 36599218
[TBL] [Abstract][Full Text] [Related]
17. The multitargeted kinase inhibitor KW-2449 ameliorates cisplatin-induced nephrotoxicity by targeting RIPK1-mediated necroptosis.
Rui C; Shi SN; Ren W; Qin X; Zhuang C; Chen X; Chen G; Yu J; Wang HY; Cai Z
Biochem Pharmacol; 2021 Jun; 188():114542. PubMed ID: 33819469
[TBL] [Abstract][Full Text] [Related]
18. Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis.
Newton K; Dugger DL; Wickliffe KE; Kapoor N; de Almagro MC; Vucic D; Komuves L; Ferrando RE; French DM; Webster J; Roose-Girma M; Warming S; Dixit VM
Science; 2014 Mar; 343(6177):1357-60. PubMed ID: 24557836
[TBL] [Abstract][Full Text] [Related]
19. Smac mimetic triggers necroptosis in pancreatic carcinoma cells when caspase activation is blocked.
Hannes S; Abhari BA; Fulda S
Cancer Lett; 2016 Sep; 380(1):31-8. PubMed ID: 27267809
[TBL] [Abstract][Full Text] [Related]
20. Inhibition of keratinocyte necroptosis mediated by RIPK1/RIPK3/MLKL provides a protective effect against psoriatic inflammation.
Duan X; Liu X; Liu N; Huang Y; Jin Z; Zhang S; Ming Z; Chen H
Cell Death Dis; 2020 Feb; 11(2):134. PubMed ID: 32075957
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
