166 related articles for article (PubMed ID: 33739090)
1. Mutation-Induced Impacts on the Switch Transformations of the GDP- and GTP-Bound K-Ras: Insights from Multiple Replica Gaussian Accelerated Molecular Dynamics and Free Energy Analysis.
Chen J; Zhang S; Wang W; Pang L; Zhang Q; Liu X
J Chem Inf Model; 2021 Apr; 61(4):1954-1969. PubMed ID: 33739090
[TBL] [Abstract][Full Text] [Related]
2. Conformational transformation of switch domains in GDP/K-Ras induced by G13 mutants: An investigation through Gaussian accelerated molecular dynamics simulations and principal component analysis.
Chen J; Wang L; Wang W; Sun H; Pang L; Bao H
Comput Biol Med; 2021 Aug; 135():104639. PubMed ID: 34247129
[TBL] [Abstract][Full Text] [Related]
3. Probing mutation-induced conformational transformation of the GTP/M-RAS complex through Gaussian accelerated molecular dynamics simulations.
Bao H; Wang W; Sun H; Chen J
J Enzyme Inhib Med Chem; 2023 Dec; 38(1):2195995. PubMed ID: 37057639
[TBL] [Abstract][Full Text] [Related]
4. KRAS Switch Mutants D33E and A59G Crystallize in the State 1 Conformation.
Lu J; Bera AK; Gondi S; Westover KD
Biochemistry; 2018 Jan; 57(3):324-333. PubMed ID: 29235861
[TBL] [Abstract][Full Text] [Related]
5. Delineating the RAS Conformational Landscape.
Parker MI; Meyer JE; Golemis EA; Dunbrack RL
Cancer Res; 2022 Jul; 82(13):2485-2498. PubMed ID: 35536216
[TBL] [Abstract][Full Text] [Related]
6. Impacts of Mutations in the P-Loop on Conformational Alterations of KRAS Investigated with Gaussian Accelerated Molecular Dynamics Simulations.
Shi S; Zheng L; Ren Y; Wang Z
Molecules; 2023 Mar; 28(7):. PubMed ID: 37049650
[TBL] [Abstract][Full Text] [Related]
7. Binding modes of GDP, GTP and GNP to NRAS deciphered by using Gaussian accelerated molecular dynamics simulations.
Bao HY; Wang W; Sun HB; Chen JZ
SAR QSAR Environ Res; 2023 Jan; 34(1):65-89. PubMed ID: 36762439
[TBL] [Abstract][Full Text] [Related]
8. Conformational States of the GDP- and GTP-Bound HRAS Affected by A59E and K117R: An Exploration from Gaussian Accelerated Molecular Dynamics.
Yu Z; Wang Z; Cui X; Cao Z; Zhang W; Sun K; Hu G
Molecules; 2024 Jan; 29(3):. PubMed ID: 38338389
[TBL] [Abstract][Full Text] [Related]
9. Conformational Dynamics Allows Sampling of an "Active-like" State by Oncogenic K-Ras-GDP.
Grudzien P; Jang H; Leschinsky N; Nussinov R; Gaponenko V
J Mol Biol; 2022 Sep; 434(17):167695. PubMed ID: 35752212
[TBL] [Abstract][Full Text] [Related]
10. Active and Inactive Cdc42 Differ in Their Insert Region Conformational Dynamics.
Haspel N; Jang H; Nussinov R
Biophys J; 2021 Jan; 120(2):306-318. PubMed ID: 33347888
[TBL] [Abstract][Full Text] [Related]
11. The Structural Basis of Oncogenic Mutations G12, G13 and Q61 in Small GTPase K-Ras4B.
Lu S; Jang H; Nussinov R; Zhang J
Sci Rep; 2016 Feb; 6():21949. PubMed ID: 26902995
[TBL] [Abstract][Full Text] [Related]
12. Deciphering Conformational Changes of the GDP-Bound NRAS Induced by Mutations G13D, Q61R, and C118S through Gaussian Accelerated Molecular Dynamic Simulations.
Yu Z; Su H; Chen J; Hu G
Molecules; 2022 Aug; 27(17):. PubMed ID: 36080363
[TBL] [Abstract][Full Text] [Related]
13. Mutational landscape of K-Ras substitutions at 12th position-a systematic molecular dynamics approach.
S UK; R B; D TK; Doss CGP; Zayed H
J Biomol Struct Dyn; 2022 Mar; 40(4):1571-1585. PubMed ID: 33034275
[TBL] [Abstract][Full Text] [Related]
14. The switch states of the GDP-bound HRAS affected by point mutations: a study from Gaussian accelerated molecular dynamics simulations and free energy landscapes.
Bao H; Wang W; Sun H; Chen J
J Biomol Struct Dyn; 2024 Apr; 42(7):3363-3381. PubMed ID: 37216340
[TBL] [Abstract][Full Text] [Related]
15. The Importance of Mg
Pálfy G; Menyhárd DK; Ákontz-Kiss H; Vida I; Batta G; Tőke O; Perczel A
Chemistry; 2022 Oct; 28(59):e202201449. PubMed ID: 35781716
[TBL] [Abstract][Full Text] [Related]
16. The distinct conformational dynamics of K-Ras and H-Ras A59G.
Lukman S; Grant BJ; Gorfe AA; Grant GH; McCammon JA
PLoS Comput Biol; 2010 Sep; 6(9):. PubMed ID: 20838576
[TBL] [Abstract][Full Text] [Related]
17. Structural insight into the rearrangement of the switch I region in GTP-bound G12A K-Ras.
Xu S; Long BN; Boris GH; Chen A; Ni S; Kennedy MA
Acta Crystallogr D Struct Biol; 2017 Dec; 73(Pt 12):970-984. PubMed ID: 29199977
[TBL] [Abstract][Full Text] [Related]
18. What makes Ras an efficient molecular switch: a computational, biophysical, and structural study of Ras-GDP interactions with mutants of Raf.
Filchtinski D; Sharabi O; Rüppel A; Vetter IR; Herrmann C; Shifman JM
J Mol Biol; 2010 Jun; 399(3):422-35. PubMed ID: 20361980
[TBL] [Abstract][Full Text] [Related]
19. Differential dynamics of RAS isoforms in GDP- and GTP-bound states.
Kapoor A; Travesset A
Proteins; 2015 Jun; 83(6):1091-106. PubMed ID: 25846136
[TBL] [Abstract][Full Text] [Related]
20.
Pálfy G; Vida I; Perczel A
Biomol NMR Assign; 2020 Apr; 14(1):1-7. PubMed ID: 31468366
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]