153 related articles for article (PubMed ID: 33749283)
1. Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy.
Terrett JA; Chen H; Shore DG; Villemure E; Larouche-Gauthier R; Déry M; Beaumier F; Constantineau-Forget L; Grand-Maître C; Lépissier L; Ciblat S; Sturino C; Chen Y; Hu B; Lu A; Wang Y; Cridland AP; Ward SI; Hackos DH; Reese RM; Shields SD; Chen J; Balestrini A; Riol-Blanco L; Lee WP; Liu J; Suto E; Wu X; Zhang J; Ly JQ; La H; Johnson K; Baumgardner M; Chou KJ; Rohou A; Rougé L; Safina BS; Magnuson S; Volgraf M
J Med Chem; 2021 Apr; 64(7):3843-3869. PubMed ID: 33749283
[TBL] [Abstract][Full Text] [Related]
2. The novel TRPA1 antagonist BI01305834 inhibits ovalbumin-induced bronchoconstriction in guinea pigs.
van den Berg MPM; Nijboer-Brinksma S; Bos IST; van den Berge M; Lamb D; van Faassen M; Kema IP; Gosens R; Kistemaker LEM
Respir Res; 2021 Feb; 22(1):48. PubMed ID: 33557843
[TBL] [Abstract][Full Text] [Related]
3. Selective antagonism of TRPA1 produces limited efficacy in models of inflammatory- and neuropathic-induced mechanical hypersensitivity in rats.
Lehto SG; Weyer AD; Youngblood BD; Zhang M; Yin R; Wang W; Teffera Y; Cooke M; Stucky CL; Schenkel L; Geuns-Meyer S; Moyer BD; Wild KD; Gavva NR
Mol Pain; 2016; 12():. PubMed ID: 27899696
[TBL] [Abstract][Full Text] [Related]
4. Optimization of a Novel Quinazolinone-Based Series of Transient Receptor Potential A1 (TRPA1) Antagonists Demonstrating Potent in Vivo Activity.
Schenkel LB; Olivieri PR; Boezio AA; Deak HL; Emkey R; Graceffa RF; Gunaydin H; Guzman-Perez A; Lee JH; Teffera Y; Wang W; Youngblood BD; Yu VL; Zhang M; Gavva NR; Lehto SG; Geuns-Meyer S
J Med Chem; 2016 Mar; 59(6):2794-809. PubMed ID: 26942860
[TBL] [Abstract][Full Text] [Related]
5. Transient receptor potential ankyrin-1 causes rapid bronchodilation via nonepithelial PGE
Marsh BJ; Fryer AD; Jacoby DB; Drake MG
Am J Physiol Lung Cell Mol Physiol; 2020 May; 318(5):L943-L952. PubMed ID: 32233794
[TBL] [Abstract][Full Text] [Related]
6. Discovery of TRPA1 Antagonist
Terrett JA; Ly JQ; Katavolos P; Hasselgren C; Laing S; Zhong F; Villemure E; Déry M; Larouche-Gauthier R; Chen H; Shore DG; Lee WP; Suto E; Johnson K; Brooks M; Stablein A; Beaumier F; Constantineau-Forget L; Grand-Maître C; Lépissier L; Ciblat S; Sturino C; Chen Y; Hu B; Elstrott J; Gandham V; Joseph V; Booler H; Cain G; Chou C; Fullerton A; Lepherd M; Stainton S; Torres E; Urban K; Yu L; Zhong Y; Bao L; Chou KJ; Lin J; Zhang W; La H; Liu L; Mulder T; Chen J; Chernov-Rogan T; Johnson AR; Hackos DH; Leahey R; Shields SD; Balestrini A; Riol-Blanco L; Safina BS; Volgraf M; Magnuson S; Kakiuchi-Kiyota S
J Med Chem; 2024 Mar; 67(5):3287-3306. PubMed ID: 38431835
[TBL] [Abstract][Full Text] [Related]
7. A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment.
Balestrini A; Joseph V; Dourado M; Reese RM; Shields SD; Rougé L; Bravo DD; Chernov-Rogan T; Austin CD; Chen H; Wang L; Villemure E; Shore DGM; Verma VA; Hu B; Chen Y; Leong L; Bjornson C; Hötzel K; Gogineni A; Lee WP; Suto E; Wu X; Liu J; Zhang J; Gandham V; Wang J; Payandeh J; Ciferri C; Estevez A; Arthur CP; Kortmann J; Wong RL; Heredia JE; Doerr J; Jung M; Vander Heiden JA; Roose-Girma M; Tam L; Barck KH; Carano RAD; Ding HT; Brillantes B; Tam C; Yang X; Gao SS; Ly JQ; Liu L; Chen L; Liederer BM; Lin JH; Magnuson S; Chen J; Hackos DH; Elstrott J; Rohou A; Safina BS; Volgraf M; Bauer RN; Riol-Blanco L
J Exp Med; 2021 Apr; 218(4):. PubMed ID: 33620419
[TBL] [Abstract][Full Text] [Related]
8. Resolvin D1 and D2 Inhibit Transient Receptor Potential Vanilloid 1 and Ankyrin 1 Ion Channel Activation on Sensory Neurons via Lipid Raft Modification.
Payrits M; Horváth Á; Biró-Sütő T; Erostyák J; Makkai G; Sághy É; Pohóczky K; Kecskés A; Kecskés M; Szolcsányi J; Helyes Z; Szőke É
Int J Mol Sci; 2020 Jul; 21(14):. PubMed ID: 32708653
[TBL] [Abstract][Full Text] [Related]
9. Topical transient receptor potential ankyrin 1 antagonist treatment attenuates nociception and inflammation in an ultraviolet B radiation-induced burn model in mice.
Fialho MFP; Brum EDS; Pegoraro NS; Couto ACG; Trevisan G; Cruz L; Oliveira SM
J Dermatol Sci; 2020 Feb; 97(2):135-142. PubMed ID: 31982303
[TBL] [Abstract][Full Text] [Related]
10. Discovery of a Potent (4 R,5 S)-4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling.
Chen H; Volgraf M; Do S; Kolesnikov A; Shore DG; Verma VA; Villemure E; Wang L; Chen Y; Hu B; Lu AJ; Wu G; Xu X; Yuen PW; Zhang Y; Erickson SD; Dahl M; Brotherton-Pleiss C; Tay S; Ly JQ; Murray LJ; Chen J; Amm D; Lange W; Hackos DH; Reese RM; Shields SD; Lyssikatos JP; Safina BS; Estrada AA
J Med Chem; 2018 Apr; 61(8):3641-3659. PubMed ID: 29590749
[TBL] [Abstract][Full Text] [Related]
11. A novel 3-(4,5-diphenyl-1,3-oxazol-2-yl)propanal oxime compound is a potent Transient Receptor Potential Ankyrin 1 and Vanilloid 1 (TRPA1 and V1) receptor antagonist.
Payrits M; Sághy É; Mátyus P; Czompa A; Ludmerczki R; Deme R; Sándor Z; Helyes Z; Szőke É
Neuroscience; 2016 Jun; 324():151-62. PubMed ID: 26930003
[TBL] [Abstract][Full Text] [Related]
12. Satellite glial cells in sensory ganglia express functional transient receptor potential ankyrin 1 that is sensitized in neuropathic and inflammatory pain.
Shin SM; Itson-Zoske B; Cai Y; Qiu C; Pan B; Stucky CL; Hogan QH; Yu H
Mol Pain; 2020; 16():1744806920925425. PubMed ID: 32484015
[TBL] [Abstract][Full Text] [Related]
13. N-Cinnamoylanthranilates as human TRPA1 modulators: Structure-activity relationships and channel binding sites.
Chandrabalan A; McPhillie MJ; Morice AH; Boa AN; Sadofsky LR
Eur J Med Chem; 2019 May; 170():141-156. PubMed ID: 30878828
[TBL] [Abstract][Full Text] [Related]
14. Repeated exposure to temperature variation exacerbates airway inflammation through TRPA1 in a mouse model of asthma.
Du C; Kang J; Yu W; Chen M; Li B; Liu H; Wang H
Respirology; 2019 Mar; 24(3):238-245. PubMed ID: 30440113
[TBL] [Abstract][Full Text] [Related]
15. The acyl-glucuronide metabolite of ibuprofen has analgesic and anti-inflammatory effects via the TRPA1 channel.
De Logu F; Li Puma S; Landini L; Tuccinardi T; Poli G; Preti D; De Siena G; Patacchini R; Tsagareli MG; Geppetti P; Nassini R
Pharmacol Res; 2019 Apr; 142():127-139. PubMed ID: 30794923
[TBL] [Abstract][Full Text] [Related]
16. Transient receptor potential ankyrin 1 (TRPA1) antagonists: a patent review (2015-2019).
Chen H; Terrett JA
Expert Opin Ther Pat; 2020 Sep; 30(9):643-657. PubMed ID: 32686526
[TBL] [Abstract][Full Text] [Related]
17. Activation characteristics of transient receptor potential ankyrin 1 and its role in nociception.
Raisinghani M; Zhong L; Jeffry JA; Bishnoi M; Pabbidi RM; Pimentel F; Cao DS; Evans MS; Premkumar LS
Am J Physiol Cell Physiol; 2011 Sep; 301(3):C587-600. PubMed ID: 21653898
[TBL] [Abstract][Full Text] [Related]
18. Transient Receptor Potential Ankyrin 1 and Substance P Mediate the Development of Gastric Mucosal Lesions in a Water Immersion Restraint Stress Rat Model.
Xu Y; Jia J; Xie C; Wu Y; Tu W
Digestion; 2018; 97(3):228-239. PubMed ID: 29428952
[TBL] [Abstract][Full Text] [Related]
19. Inhibition of TRPA1 and IL-6 signal alleviates neuropathic pain following chemotherapeutic bortezomib.
Liu D; Sun M; Xu D; Ma X; Gao D; Yu H
Physiol Res; 2019 Oct; 68(5):845-855. PubMed ID: 31424261
[TBL] [Abstract][Full Text] [Related]
20. TRPA1 ankyrin repeat six interacts with a small molecule inhibitor chemotype.
Tseng WC; Pryde DC; Yoger KE; Padilla KM; Antonio BM; Han S; Shanmugasundaram V; Gerlach AC
Proc Natl Acad Sci U S A; 2018 Nov; 115(48):12301-12306. PubMed ID: 30429323
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
