147 related articles for article (PubMed ID: 33756124)
1. Scaffold repurposing of fendiline: Identification of potent KRAS plasma membrane localization inhibitors.
Wang P; van der Hoeven D; Ye N; Chen H; Liu Z; Ma X; Montufar-Solis D; Rehl KM; Cho KJ; Thapa S; Chen W; van der Hoeven R; Frost JA; Hancock JF; Zhou J
Eur J Med Chem; 2021 May; 217():113381. PubMed ID: 33756124
[TBL] [Abstract][Full Text] [Related]
2. Fendiline inhibits K-Ras plasma membrane localization and blocks K-Ras signal transmission.
van der Hoeven D; Cho KJ; Ma X; Chigurupati S; Parton RG; Hancock JF
Mol Cell Biol; 2013 Jan; 33(2):237-51. PubMed ID: 23129805
[TBL] [Abstract][Full Text] [Related]
3. Discovery of novel quinazoline-based covalent inhibitors of KRAS G12C with various cysteine-targeting warheads as potential anticancer agents.
Li L; Zhao H; Liao H; Chen J; Liu J; Chen J
Bioorg Chem; 2021 May; 110():104825. PubMed ID: 33774492
[TBL] [Abstract][Full Text] [Related]
4. Discovery, optimization and biological activity evaluation of genipin derivatives as potential KRAS G12D inhibitors.
Sun R; Hu Y; Liu X; Lin Y; Lv D; Li W; Fu L; Jiang F
Bioorg Chem; 2024 Jul; 148():107460. PubMed ID: 38781668
[TBL] [Abstract][Full Text] [Related]
5. Dependence on the Pyrimidine Biosynthetic Enzyme DHODH Is a Synthetic Lethal Vulnerability in Mutant KRAS-Driven Cancers.
Koundinya M; Sudhalter J; Courjaud A; Lionne B; Touyer G; Bonnet L; Menguy I; Schreiber I; Perrault C; Vougier S; Benhamou B; Zhang B; He T; Gao Q; Gee P; Simard D; Castaldi MP; Tomlinson R; Reiling S; Barrague M; Newcombe R; Cao H; Wang Y; Sun F; Murtie J; Munson M; Yang E; Harper D; Bouaboula M; Pollard J; Grepin C; Garcia-Echeverria C; Cheng H; Adrian F; Winter C; Licht S; Cornella-Taracido I; Arrebola R; Morris A
Cell Chem Biol; 2018 Jun; 25(6):705-717.e11. PubMed ID: 29628435
[TBL] [Abstract][Full Text] [Related]
6. Components of the phosphatidylserine endoplasmic reticulum to plasma membrane transport mechanism as targets for KRAS inhibition in pancreatic cancer.
Kattan WE; Liu J; Montufar-Solis D; Liang H; Brahmendra Barathi B; van der Hoeven R; Zhou Y; Hancock JF
Proc Natl Acad Sci U S A; 2021 Dec; 118(51):. PubMed ID: 34903667
[TBL] [Abstract][Full Text] [Related]
7. Discovery of quinazoline derivatives as a novel class of potent and in vivo efficacious LSD1 inhibitors by drug repurposing.
Li Z; Qin T; Li Z; Zhao X; Zhang X; Zhao T; Yang N; Miao J; Ma J; Zhang Z
Eur J Med Chem; 2021 Dec; 225():113778. PubMed ID: 34416665
[TBL] [Abstract][Full Text] [Related]
8. A Quadruple-Action Platinum(IV) Prodrug with Anticancer Activity Against KRAS Mutated Cancer Cell Lines.
Petruzzella E; Braude JP; Aldrich-Wright JR; Gandin V; Gibson D
Angew Chem Int Ed Engl; 2017 Sep; 56(38):11539-11544. PubMed ID: 28759160
[TBL] [Abstract][Full Text] [Related]
9. Design, synthesis and pharmacological evaluation of bicyclic and tetracyclic pyridopyrimidinone analogues as new KRAS
Xiao X; Lai M; Song Z; Geng M; Ding J; Xie H; Zhang A
Eur J Med Chem; 2021 Mar; 213():113082. PubMed ID: 33309163
[TBL] [Abstract][Full Text] [Related]
10. An oxanthroquinone derivative that disrupts RAS plasma membrane localization inhibits cancer cell growth.
Tan L; Cho KJ; Neupane P; Capon RJ; Hancock JF
J Biol Chem; 2018 Aug; 293(35):13696-13706. PubMed ID: 29970615
[TBL] [Abstract][Full Text] [Related]
11. Inhibitors of K-Ras plasma membrane localization.
Cho KJ; van der Hoeven D; Hancock JF
Enzymes; 2013; 33 Pt A():249-65. PubMed ID: 25033808
[TBL] [Abstract][Full Text] [Related]
12. Targeting mutated GTPase KRAS in tumor therapies.
Fan G; Lou L; Song Z; Zhang X; Xiong XF
Eur J Med Chem; 2021 Dec; 226():113816. PubMed ID: 34520956
[TBL] [Abstract][Full Text] [Related]
13. Discovery of KRas G12C-IN-3 and Pomalidomide-based PROTACs as degraders of endogenous KRAS G12C with potent anticancer activity.
Li L; Wu Y; Yang Z; Xu C; Zhao H; Liu J; Chen J; Chen J
Bioorg Chem; 2021 Dec; 117():105447. PubMed ID: 34715575
[TBL] [Abstract][Full Text] [Related]
14. Design, synthesis and biological evaluation of new Myo-inositol derivatives as potential RAS inhibitors.
Hussain J; Chhabria D; Kirubakaran S
Bioorg Med Chem Lett; 2020 Aug; 30(16):127290. PubMed ID: 32631512
[TBL] [Abstract][Full Text] [Related]
15. Identification of the Clinical Development Candidate
Fell JB; Fischer JP; Baer BR; Blake JF; Bouhana K; Briere DM; Brown KD; Burgess LE; Burns AC; Burkard MR; Chiang H; Chicarelli MJ; Cook AW; Gaudino JJ; Hallin J; Hanson L; Hartley DP; Hicken EJ; Hingorani GP; Hinklin RJ; Mejia MJ; Olson P; Otten JN; Rhodes SP; Rodriguez ME; Savechenkov P; Smith DJ; Sudhakar N; Sullivan FX; Tang TP; Vigers GP; Wollenberg L; Christensen JG; Marx MA
J Med Chem; 2020 Jul; 63(13):6679-6693. PubMed ID: 32250617
[TBL] [Abstract][Full Text] [Related]
16. Discovery of 6-[(3
Czako B; Sun Y; McAfoos T; Cross JB; Leonard PG; Burke JP; Carroll CL; Feng N; Harris AL; Jiang Y; Kang Z; Kovacs JJ; Mandal P; Meyers BA; Mseeh F; Parker CA; Yu SS; Williams CC; Wu Q; Di Francesco ME; Draetta G; Heffernan T; Marszalek JR; Kohl NE; Jones P
J Med Chem; 2021 Oct; 64(20):15141-15169. PubMed ID: 34643390
[TBL] [Abstract][Full Text] [Related]
17. Dual nicotinamide phosphoribosyltransferase and epidermal growth factor receptor inhibitors for the treatment of cancer.
Zhang W; Zhang K; Yao Y; Liu Y; Ni Y; Liao C; Tu Z; Qiu Y; Wang D; Chen D; Qiang L; Li Z; Jiang S
Eur J Med Chem; 2021 Feb; 211():113022. PubMed ID: 33239261
[TBL] [Abstract][Full Text] [Related]
18. Selective apoptosis-inducing activity of synthetic hydrocarbon-stapled SOS1 helix with d-amino acids in H358 cancer cells expressing KRAS
Xu LL; Li CC; An LY; Dai Z; Chen XY; You QD; Hu C; Di B
Eur J Med Chem; 2020 Jan; 185():111844. PubMed ID: 31706640
[TBL] [Abstract][Full Text] [Related]
19. Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor.
Janes MR; Zhang J; Li LS; Hansen R; Peters U; Guo X; Chen Y; Babbar A; Firdaus SJ; Darjania L; Feng J; Chen JH; Li S; Li S; Long YO; Thach C; Liu Y; Zarieh A; Ely T; Kucharski JM; Kessler LV; Wu T; Yu K; Wang Y; Yao Y; Deng X; Zarrinkar PP; Brehmer D; Dhanak D; Lorenzi MV; Hu-Lowe D; Patricelli MP; Ren P; Liu Y
Cell; 2018 Jan; 172(3):578-589.e17. PubMed ID: 29373830
[TBL] [Abstract][Full Text] [Related]
20. Oncogenic KRAS is dependent upon an EFR3A-PI4KA signaling axis for potent tumorigenic activity.
Adhikari H; Kattan WE; Kumar S; Zhou P; Hancock JF; Counter CM
Nat Commun; 2021 Sep; 12(1):5248. PubMed ID: 34504076
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]