328 related articles for article (PubMed ID: 33780087)
1. Serpin neuropathology in the P497S UBQLN2 mouse model of ALS/FTD.
Higgins NR; Greenslade JE; Wu JJ; Miranda E; Galliciotti G; Monteiro MJ
Brain Pathol; 2021 Sep; 31(5):e12948. PubMed ID: 33780087
[TBL] [Abstract][Full Text] [Related]
2. Overexpression of UBQLN1 reduces neuropathology in the P497S UBQLN2 mouse model of ALS/FTD.
Wang S; Tatman M; Monteiro MJ
Acta Neuropathol Commun; 2020 Oct; 8(1):164. PubMed ID: 33028421
[TBL] [Abstract][Full Text] [Related]
3. ALS/FTD mutations in UBQLN2 impede autophagy by reducing autophagosome acidification through loss of function.
Wu JJ; Cai A; Greenslade JE; Higgins NR; Fan C; Le NTT; Tatman M; Whiteley AM; Prado MA; Dieriks BV; Curtis MA; Shaw CE; Siddique T; Faull RLM; Scotter EL; Finley D; Monteiro MJ
Proc Natl Acad Sci U S A; 2020 Jun; 117(26):15230-15241. PubMed ID: 32513711
[TBL] [Abstract][Full Text] [Related]
4. ALS/FTD mutations in UBQLN2 are linked to mitochondrial dysfunction through loss-of-function in mitochondrial protein import.
Lin BC; Phung TH; Higgins NR; Greenslade JE; Prado MA; Finley D; Karbowski M; Polster BM; Monteiro MJ
Hum Mol Genet; 2021 Jun; 30(13):1230-1246. PubMed ID: 33891006
[TBL] [Abstract][Full Text] [Related]
5. Modeling UBQLN2-mediated neurodegenerative disease in mice: Shared and divergent properties of wild type and mutant UBQLN2 in phase separation, subcellular localization, altered proteostasis pathways, and selective cytotoxicity.
Sharkey LM; Sandoval-Pistorius SS; Moore SJ; Gerson JE; Komlo R; Fischer S; Negron-Rios KY; Crowley EV; Padron F; Patel R; Murphy GG; Paulson HL
Neurobiol Dis; 2020 Sep; 143():105016. PubMed ID: 32653673
[TBL] [Abstract][Full Text] [Related]
6. Motor neuron disease, TDP-43 pathology, and memory deficits in mice expressing ALS-FTD-linked UBQLN2 mutations.
Le NT; Chang L; Kovlyagina I; Georgiou P; Safren N; Braunstein KE; Kvarta MD; Van Dyke AM; LeGates TA; Philips T; Morrison BM; Thompson SM; Puche AC; Gould TD; Rothstein JD; Wong PC; Monteiro MJ
Proc Natl Acad Sci U S A; 2016 Nov; 113(47):E7580-E7589. PubMed ID: 27834214
[TBL] [Abstract][Full Text] [Related]
7. UBQLN2-HSP70 axis reduces poly-Gly-Ala aggregates and alleviates behavioral defects in the C9ORF72 animal model.
Zhang K; Wang A; Zhong K; Qi S; Wei C; Shu X; Tu WY; Xu W; Xia C; Xiao Y; Chen A; Bai L; Zhang J; Luo B; Wang W; Shen C
Neuron; 2021 Jun; 109(12):1949-1962.e6. PubMed ID: 33991504
[TBL] [Abstract][Full Text] [Related]
8. Key role of UBQLN2 in pathogenesis of amyotrophic lateral sclerosis and frontotemporal dementia.
Renaud L; Picher-Martel V; Codron P; Julien JP
Acta Neuropathol Commun; 2019 Jul; 7(1):103. PubMed ID: 31319884
[TBL] [Abstract][Full Text] [Related]
9. Global proteomics of Ubqln2-based murine models of ALS.
Whiteley AM; Prado MA; de Poot SAH; Paulo JA; Ashton M; Dominguez S; Weber M; Ngu H; Szpyt J; Jedrychowski MP; Easton A; Gygi SP; Kurz T; Monteiro MJ; Brown EJ; Finley D
J Biol Chem; 2021; 296():100153. PubMed ID: 33277362
[TBL] [Abstract][Full Text] [Related]
10. Multi-omics profiling identifies a deregulated FUS-MAP1B axis in ALS/FTD-associated UBQLN2 mutants.
Strohm L; Hu Z; Suk Y; Rühmkorf A; Sternburg E; Gattringer V; Riemenschneider H; Berutti R; Graf E; Weishaupt JH; Brill MS; Harbauer AB; Dormann D; Dengjel J; Edbauer D; Behrends C
Life Sci Alliance; 2022 Nov; 5(11):. PubMed ID: 35777956
[TBL] [Abstract][Full Text] [Related]
11. Axon guidance genes modulate neurotoxicity of ALS-associated UBQLN2.
Kim SH; Nichols KD; Anderson EN; Liu Y; Ramesh N; Jia W; Kuerbis CJ; Scalf M; Smith LM; Pandey UB; Tibbetts RS
Elife; 2023 Apr; 12():. PubMed ID: 37039476
[TBL] [Abstract][Full Text] [Related]
12. UBQLN2 undergoes a reversible temperature-induced conformational switch that regulates binding with HSPA1B: ALS/FTD mutations cripple the switch but do not destroy HSPA1B binding.
Phung TH; Tatman M; Monteiro MJ
Biochim Biophys Acta Gen Subj; 2023 Feb; 1867(2):130284. PubMed ID: 36423739
[TBL] [Abstract][Full Text] [Related]
13. Amyotrophic lateral sclerosis-linked UBQLN2 mutants inhibit endoplasmic reticulum to Golgi transport, leading to Golgi fragmentation and ER stress.
Halloran M; Ragagnin AMG; Vidal M; Parakh S; Yang S; Heng B; Grima N; Shahheydari H; Soo KY; Blair I; Guillemin GJ; Sundaramoorthy V; Atkin JD
Cell Mol Life Sci; 2020 Oct; 77(19):3859-3873. PubMed ID: 31802140
[TBL] [Abstract][Full Text] [Related]
14. Amyotrophic lateral sclerosis (ALS) linked mutation in Ubiquilin 2 affects stress granule assembly via TIA-1.
Peng G; Gu A; Niu H; Chen L; Chen Y; Zhou M; Zhang Y; Liu J; Cai L; Liang D; Liu X; Liu M
CNS Neurosci Ther; 2022 Jan; 28(1):105-115. PubMed ID: 34750982
[TBL] [Abstract][Full Text] [Related]
15. ALS-linked mutations impair UBQLN2 stress-induced biomolecular condensate assembly in cells.
Riley JF; Fioramonti PJ; Rusnock AK; Hehnly H; Castañeda CA
J Neurochem; 2021 Oct; 159(1):145-155. PubMed ID: 34129687
[TBL] [Abstract][Full Text] [Related]
16. UBQLN2/P62 cellular recycling pathways in amyotrophic lateral sclerosis and frontotemporal dementia.
Fecto F; Siddique T
Muscle Nerve; 2012 Feb; 45(2):157-62. PubMed ID: 22246868
[TBL] [Abstract][Full Text] [Related]
17. Evidence of a link between ubiquilin 2 and optineurin in amyotrophic lateral sclerosis.
Osaka M; Ito D; Yagi T; Nihei Y; Suzuki N
Hum Mol Genet; 2015 Mar; 24(6):1617-29. PubMed ID: 25398946
[TBL] [Abstract][Full Text] [Related]
18. Genetic and immunopathological analysis of CHCHD10 in Australian amyotrophic lateral sclerosis and frontotemporal dementia and transgenic TDP-43 mice.
McCann EP; Fifita JA; Grima N; Galper J; Mehta P; Freckleton SE; Zhang KY; Henden L; Hogan AL; Chan Moi Fat S; Wu SS; Jagaraj CJ; Berning BA; Williams KL; Twine NA; Bauer D; Piguet O; Hodges J; Kwok JBJ; Halliday GM; Kiernan MC; Atkin J; Rowe DB; Nicholson GA; Walker AK; Blair IP; Yang S
J Neurol Neurosurg Psychiatry; 2020 Feb; 91(2):162-171. PubMed ID: 31690696
[TBL] [Abstract][Full Text] [Related]
19. Viral expression of ALS-linked ubiquilin-2 mutants causes inclusion pathology and behavioral deficits in mice.
Ceballos-Diaz C; Rosario AM; Park HJ; Chakrabarty P; Sacino A; Cruz PE; Siemienski Z; Lara N; Moran C; Ravelo N; Golde TE; McFarland NR
Mol Neurodegener; 2015 Jul; 10():25. PubMed ID: 26152284
[TBL] [Abstract][Full Text] [Related]
20. Mutant UBQLN2
Chen T; Huang B; Shi X; Gao L; Huang C
Acta Neuropathol Commun; 2018 Nov; 6(1):122. PubMed ID: 30409191
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
