411 related articles for article (PubMed ID: 33788542)
1. Fluspirilene Analogs Activate the 20S Proteasome and Overcome Proteasome Impairment by Intrinsically Disordered Protein Oligomers.
Fiolek TJ; Keel KL; Tepe JJ
ACS Chem Neurosci; 2021 Apr; 12(8):1438-1448. PubMed ID: 33788542
[TBL] [Abstract][Full Text] [Related]
2. Dihydroquinazolines enhance 20S proteasome activity and induce degradation of α-synuclein, an intrinsically disordered protein associated with neurodegeneration.
Fiolek TJ; Magyar CL; Wall TJ; Davies SB; Campbell MV; Savich CJ; Tepe JJ; Mosey RA
Bioorg Med Chem Lett; 2021 Mar; 36():127821. PubMed ID: 33513387
[TBL] [Abstract][Full Text] [Related]
3. Design, Synthesis, and Biological Evaluation of Potent 20S Proteasome Activators for the Potential Treatment of α-Synucleinopathies.
Staerz SD; Jones CL; Tepe JJ
J Med Chem; 2022 May; 65(9):6631-6642. PubMed ID: 35476454
[TBL] [Abstract][Full Text] [Related]
4. Insights into the Molecular Mechanisms of Alzheimer's and Parkinson's Diseases with Molecular Simulations: Understanding the Roles of Artificial and Pathological Missense Mutations in Intrinsically Disordered Proteins Related to Pathology.
Coskuner-Weber O; Uversky VN
Int J Mol Sci; 2018 Jan; 19(2):. PubMed ID: 29364151
[TBL] [Abstract][Full Text] [Related]
5. Syrosingopine Enhances 20S Proteasome Activity and Degradation of α-Synuclein.
Sadahiro Y; Nishimura S; Hitora Y; Tsukamoto S
J Nat Prod; 2024 Mar; 87(3):554-559. PubMed ID: 37938154
[TBL] [Abstract][Full Text] [Related]
6. Small Molecule Modulation of Proteasome Assembly.
Njomen E; Osmulski PA; Jones CL; Gaczynska M; Tepe JJ
Biochemistry; 2018 Jul; 57(28):4214-4224. PubMed ID: 29897236
[TBL] [Abstract][Full Text] [Related]
7. Small Molecule Enhancement of 20S Proteasome Activity Targets Intrinsically Disordered Proteins.
Jones CL; Njomen E; Sjögren B; Dexheimer TS; Tepe JJ
ACS Chem Biol; 2017 Sep; 12(9):2240-2247. PubMed ID: 28719185
[TBL] [Abstract][Full Text] [Related]
8. A Fragment-Based Method of Creating Small-Molecule Libraries to Target the Aggregation of Intrinsically Disordered Proteins.
Joshi P; Chia S; Habchi J; Knowles TP; Dobson CM; Vendruscolo M
ACS Comb Sci; 2016 Mar; 18(3):144-53. PubMed ID: 26923286
[TBL] [Abstract][Full Text] [Related]
9. Modulation of Disordered Proteins with a Focus on Neurodegenerative Diseases and Other Pathologies.
Martinelli AHS; Lopes FC; John EBO; Carlini CR; Ligabue-Braun R
Int J Mol Sci; 2019 Mar; 20(6):. PubMed ID: 30875980
[TBL] [Abstract][Full Text] [Related]
10. Structures of the intrinsically disordered Aβ, tau and α-synuclein proteins in aqueous solution from computer simulations.
Nguyen PH; Derreumaux P
Biophys Chem; 2020 Sep; 264():106421. PubMed ID: 32623047
[TBL] [Abstract][Full Text] [Related]
11. Proteasome Activation to Combat Proteotoxicity.
Jones CL; Tepe JJ
Molecules; 2019 Aug; 24(15):. PubMed ID: 31387243
[TBL] [Abstract][Full Text] [Related]
12. The C-Terminus of the PSMA3 Proteasome Subunit Preferentially Traps Intrinsically Disordered Proteins for Degradation.
Biran A; Myers N; Steinberger S; Adler J; Riutin M; Broennimann K; Reuven N; Shaul Y
Cells; 2022 Oct; 11(20):. PubMed ID: 36291102
[TBL] [Abstract][Full Text] [Related]
13. Proteasomal degradation of the intrinsically disordered protein tau at single-residue resolution.
Ukmar-Godec T; Fang P; Ibáñez de Opakua A; Henneberg F; Godec A; Pan KT; Cima-Omori MS; Chari A; Mandelkow E; Urlaub H; Zweckstetter M
Sci Adv; 2020 Jul; 6(30):eaba3916. PubMed ID: 32832664
[TBL] [Abstract][Full Text] [Related]
14. Proteasome activation: A novel strategy for targeting undruggable intrinsically disordered proteins.
Yu Q; Wang Z; Tu Y; Cao Y; Zhu H; Shao J; Zhuang R; Zhou Y; Zhang J
Bioorg Chem; 2024 Apr; 145():107217. PubMed ID: 38368657
[TBL] [Abstract][Full Text] [Related]
15. Aim for the core: suitability of the ubiquitin-independent 20S proteasome as a drug target in neurodegeneration.
Opoku-Nsiah KA; Gestwicki JE
Transl Res; 2018 Aug; 198():48-57. PubMed ID: 30244692
[TBL] [Abstract][Full Text] [Related]
16. Development of a Cell-Based AlphaLISA Assay for High-Throughput Screening for Small Molecule Proteasome Modulators.
Staerz SD; Lisabeth EM; Njomen E; Dexheimer TS; Neubig RR; Tepe JJ
ACS Omega; 2023 May; 8(17):15650-15659. PubMed ID: 37151549
[TBL] [Abstract][Full Text] [Related]
17. AM404 Analogs as Activators of the 20S Isoform of the Human Proteasome.
Salazar-Chaparro A; Kragness K; Feleciano D; Trader DJ
Chembiochem; 2024 Jun; 25(12):e202400284. PubMed ID: 38609329
[TBL] [Abstract][Full Text] [Related]
18. Synergistic Amyloid Switch Triggered by Early Heterotypic Oligomerization of Intrinsically Disordered α-Synuclein and Tau.
Bhasne K; Sebastian S; Jain N; Mukhopadhyay S
J Mol Biol; 2018 Aug; 430(16):2508-2520. PubMed ID: 29704492
[TBL] [Abstract][Full Text] [Related]
19. Disordered Substrates of the 20S Proteasome Link Degradation with Phase Separation.
Guharoy M; Lazar T; Tompa P
Proteomics; 2018 Nov; 18(21-22):e1800276. PubMed ID: 30070766
[TBL] [Abstract][Full Text] [Related]
20. The Disordered Landscape of the 20S Proteasome Substrates Reveals Tight Association with Phase Separated Granules.
Myers N; Olender T; Savidor A; Levin Y; Reuven N; Shaul Y
Proteomics; 2018 Nov; 18(21-22):e1800076. PubMed ID: 30039638
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]