127 related articles for article (PubMed ID: 33797924)
1. Discovery of Ethyl Ketone-Based Highly Selective HDACs 1, 2, 3 Inhibitors for HIV Latency Reactivation with Minimum Cellular Potency Serum Shift and Reduced hERG Activity.
Yu W; Liu J; Clausen D; Yu Y; Duffy JL; Wang M; Xu S; Deng L; Suzuki T; Chung CC; Myers RW; Klein DJ; Fells JI; Holloway MK; Wu J; Wu G; Howell BJ; Barnard RJO; Kozlowski J
J Med Chem; 2021 Apr; 64(8):4709-4729. PubMed ID: 33797924
[TBL] [Abstract][Full Text] [Related]
2. Discovery of ethyl ketone-based HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation.
Yu W; Liu J; Yu Y; Zhang V; Clausen D; Kelly J; Wolkenberg S; Beshore D; Duffy JL; Chung CC; Myers RW; Klein DJ; Fells J; Holloway K; Wu J; Wu G; Howell BJ; Barnard RJO; Kozlowski J
Bioorg Med Chem Lett; 2020 Jul; 30(13):127197. PubMed ID: 32331932
[TBL] [Abstract][Full Text] [Related]
3. Discovery of macrocyclic HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation.
Yu W; Fells J; Clausen D; Liu J; Klein DJ; Christine Chung C; Myers RW; Wu J; Wu G; Howell BJ; Barnard RJO; Kozlowski J
Bioorg Med Chem Lett; 2021 Sep; 47():128168. PubMed ID: 34091041
[TBL] [Abstract][Full Text] [Related]
4. Design, synthesis and biological evaluation of novel histone deacetylase inhibitors incorporating 4-aminoquinazolinyl systems as capping groups.
Zhang Q; Li Y; Zhang B; Lu B; Li J
Bioorg Med Chem Lett; 2017 Nov; 27(21):4885-4888. PubMed ID: 28947154
[TBL] [Abstract][Full Text] [Related]
5. Inhibitory selectivity among class I HDACs has a major impact on inflammatory gene expression in macrophages.
Cao F; Zwinderman MRH; van Merkerk R; Ettema PE; Quax WJ; Dekker FJ
Eur J Med Chem; 2019 Sep; 177():457-466. PubMed ID: 31181405
[TBL] [Abstract][Full Text] [Related]
6. Discovery, bioactivity and docking simulation of Vorinostat analogues containing 1,2,4-oxadiazole moiety as potent histone deacetylase inhibitors and antitumor agents.
Cai J; Wei H; Hong KH; Wu X; Zong X; Cao M; Wang P; Li L; Sun C; Chen B; Zhou G; Chen J; Ji M
Bioorg Med Chem; 2015 Jul; 23(13):3457-71. PubMed ID: 25953722
[TBL] [Abstract][Full Text] [Related]
7. Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors.
Wagner FF; Weïwer M; Steinbacher S; Schomburg A; Reinemer P; Gale JP; Campbell AJ; Fisher SL; Zhao WN; Reis SA; Hennig KM; Thomas M; Müller P; Jefson MR; Fass DM; Haggarty SJ; Zhang YL; Holson EB
Bioorg Med Chem; 2016 Sep; 24(18):4008-4015. PubMed ID: 27377864
[TBL] [Abstract][Full Text] [Related]
8. Inhibitors of histone deacetylases: correlation between isoform specificity and reactivation of HIV type 1 (HIV-1) from latently infected cells.
Huber K; Doyon G; Plaks J; Fyne E; Mellors JW; Sluis-Cremer N
J Biol Chem; 2011 Jun; 286(25):22211-8. PubMed ID: 21531716
[TBL] [Abstract][Full Text] [Related]
9. Class 1-Selective Histone Deacetylase (HDAC) Inhibitors Enhance HIV Latency Reversal while Preserving the Activity of HDAC Isoforms Necessary for Maximal HIV Gene Expression.
Zaikos TD; Painter MM; Sebastian Kettinger NT; Terry VH; Collins KL
J Virol; 2018 Mar; 92(6):. PubMed ID: 29298886
[TBL] [Abstract][Full Text] [Related]
10. Design, synthesis and biological evaluation of novel indazole-based derivatives as potent HDAC inhibitors via fragment-based virtual screening.
Liu J; Zhou J; He F; Gao L; Wen Y; Gao L; Wang P; Kang D; Hu L
Eur J Med Chem; 2020 Apr; 192():112189. PubMed ID: 32151834
[TBL] [Abstract][Full Text] [Related]
11. Optimization of a series of potent and selective ketone histone deacetylase inhibitors.
Pescatore G; Kinzel O; Attenni B; Cecchetti O; Fiore F; Fonsi M; Rowley M; Schultz-Fademrecht C; Serafini S; Steinkühler C; Jones P
Bioorg Med Chem Lett; 2008 Oct; 18(20):5528-32. PubMed ID: 18809328
[TBL] [Abstract][Full Text] [Related]
12. Development of a selective HDAC inhibitor aimed at reactivating the HIV latent reservoir.
Clausen DJ; Liu J; Yu W; Duffy JL; Chung CC; Myers RW; Klein DJ; Fells J; Holloway K; Wu J; Wu G; Howell BJ; Barnard RJO; Kozlowski J
Bioorg Med Chem Lett; 2020 Sep; 30(17):127367. PubMed ID: 32738976
[TBL] [Abstract][Full Text] [Related]
13. Synthesis and Biological Investigation of Oxazole Hydroxamates as Highly Selective Histone Deacetylase 6 (HDAC6) Inhibitors.
Senger J; Melesina J; Marek M; Romier C; Oehme I; Witt O; Sippl W; Jung M
J Med Chem; 2016 Feb; 59(4):1545-55. PubMed ID: 26653328
[TBL] [Abstract][Full Text] [Related]
14. Novel Class IIa-Selective Histone Deacetylase Inhibitors Discovered Using an in Silico Virtual Screening Approach.
Hsu KC; Liu CY; Lin TE; Hsieh JH; Sung TY; Tseng HJ; Yang JM; Huang WJ
Sci Rep; 2017 Jun; 7(1):3228. PubMed ID: 28607401
[TBL] [Abstract][Full Text] [Related]
15. How to Distinguish Between the Activity of HDAC1-3 and HDAC6 with Western Blot.
Beyer M; Kiweler N; Mahboobi S; Krämer OH
Methods Mol Biol; 2017; 1510():355-364. PubMed ID: 27761834
[TBL] [Abstract][Full Text] [Related]
16. Docking of hydroxamic acids into HDAC1 and HDAC8: a rationalization of activity trends and selectivities.
Ortore G; Di Colo F; Martinelli A
J Chem Inf Model; 2009 Dec; 49(12):2774-85. PubMed ID: 19947584
[TBL] [Abstract][Full Text] [Related]
17. The effect of various zinc binding groups on inhibition of histone deacetylases 1-11.
Madsen AS; Kristensen HM; Lanz G; Olsen CA
ChemMedChem; 2014 Mar; 9(3):614-26. PubMed ID: 24375963
[TBL] [Abstract][Full Text] [Related]
18. Developing selective histone deacetylases (HDACs) inhibitors through ebselen and analogs.
Wang Y; Wallach J; Duane S; Wang Y; Wu J; Wang J; Adejare A; Ma H
Drug Des Devel Ther; 2017; 11():1369-1382. PubMed ID: 28496307
[TBL] [Abstract][Full Text] [Related]
19. Novel histone deacetylase inhibitors CG05 and CG06 effectively reactivate latently infected HIV-1.
Choi BS; Lee HS; Oh YT; Hyun YL; Ro S; Kim SS; Hong KJ
AIDS; 2010 Feb; 24(4):609-11. PubMed ID: 20154582
[TBL] [Abstract][Full Text] [Related]
20. Computational identification of novel histone deacetylase inhibitors by docking based QSAR.
Nair SB; Teli MK; Pradeep H; Rajanikant GK
Comput Biol Med; 2012 Jun; 42(6):697-705. PubMed ID: 22521374
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
