These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

111 related articles for article (PubMed ID: 3380791)

  • 1. Probing the salt bridge in the dihydrofolate reductase-methotrexate complex by using the coordinate-coupled free-energy perturbation method.
    Singh UC
    Proc Natl Acad Sci U S A; 1988 Jun; 85(12):4280-4. PubMed ID: 3380791
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A free-energy perturbation study of the binding of methotrexate to mutants of dihydrofolate reductase.
    Singh UC; Benkovic SJ
    Proc Natl Acad Sci U S A; 1988 Dec; 85(24):9519-23. PubMed ID: 3200837
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Evaluation of the importance of hydrophobic interactions in drug binding to dihydrofolate reductase.
    Taira K; Benkovic SJ
    J Med Chem; 1988 Jan; 31(1):129-37. PubMed ID: 3275776
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Role of aspartate 27 in the binding of methotrexate to dihydrofolate reductase from Escherichia coli.
    Appleman JR; Howell EE; Kraut J; Kühl M; Blakley RL
    J Biol Chem; 1988 Jul; 263(19):9187-98. PubMed ID: 3288632
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Construction of an altered proton donation mechanism in Escherichia coli dihydrofolate reductase.
    Howell EE; Warren MS; Booth CL; Villafranca JE; Kraut J
    Biochemistry; 1987 Dec; 26(26):8591-8. PubMed ID: 2894842
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Consideration of the pH-dependent inhibition of dihydrofolate reductase by methotrexate.
    Cannon WR; Garrison BJ; Benkovic SJ
    J Mol Biol; 1997 Aug; 271(4):656-68. PubMed ID: 9281432
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Interaction of methotrexate, folates, and pyridine nucleotides with dihydrofolate reductase: calorimetric and spectroscopic binding studies.
    Subramanian S; Kaufman BT
    Proc Natl Acad Sci U S A; 1978 Jul; 75(7):3201-5. PubMed ID: 28523
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Interaction of dihydrofolate reductase with methotrexate: ensemble and single-molecule kinetics.
    Rajagopalan PT; Zhang Z; McCourt L; Dwyer M; Benkovic SJ; Hammes GG
    Proc Natl Acad Sci U S A; 2002 Oct; 99(21):13481-6. PubMed ID: 12359872
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Role of ionic interactions in ligand binding and catalysis of R67 dihydrofolate reductase.
    Hicks SN; Smiley RD; Hamilton JB; Howell EE
    Biochemistry; 2003 Sep; 42(36):10569-78. PubMed ID: 12962480
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Thermodynamic study of the influence of NADPH on the binding of methotrexate and its metabolites to a mammalian dihydrofolate reductase.
    Gilli RM; Sari JC; Sica LM; Briand CM
    Biochim Biophys Acta; 1988 Jan; 964(1):53-60. PubMed ID: 3334873
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Effects of distal point-site mutations on the binding and catalysis of dihydrofolate reductase from Escherichia coli.
    Adams J; Johnson K; Matthews R; Benkovic SJ
    Biochemistry; 1989 Aug; 28(16):6611-8. PubMed ID: 2675972
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Probing the functional role of threonine-113 of Escherichia coli dihydrofolate reductase for its effect on turnover efficiency, catalysis, and binding.
    Fierke CA; Benkovic SJ
    Biochemistry; 1989 Jan; 28(2):478-86. PubMed ID: 2496745
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Thermodynamic characterization of the interactions of methotrexate with dihydrofolate reductase by quantitative affinity chromatography.
    Waltham MC; Holland JW; Nixon PF; Winzor DJ
    Biochem Pharmacol; 1988 Feb; 37(3):541-5. PubMed ID: 3122765
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Evidence for two interconverting protein isomers in the methotrexate complex of dihydrofolate reductase from Escherichia coli.
    Falzone CJ; Wright PE; Benkovic SJ
    Biochemistry; 1991 Feb; 30(8):2184-91. PubMed ID: 1998678
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Nuclear magnetic resonance study of the state of protonation of inhibitors bound to mutant dihydrofolate reductase lacking the active-site carboxyl.
    London RE; Howell EE; Warren MS; Kraut J; Blakley RL
    Biochemistry; 1986 Nov; 25(22):7229-35. PubMed ID: 3542023
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Dihydrofolate reductase: x-ray structure of the binary complex with methotrexate.
    Matthews DA; Alden RA; Bolin JT; Freer ST; Hamlin R; Xuong N; Kraut J; Poe M; Williams M; Hoogsteen K
    Science; 1977 Jul; 197(4302):452-5. PubMed ID: 17920
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Computational predictions of binding affinities to dihydrofolate reductase: synthesis and biological evaluation of methotrexate analogues.
    Graffner-Nordberg M; Marelius J; Ohlsson S; Persson A; Swedberg G; Andersson P; Andersson SE; Aqvist J; Hallberg A
    J Med Chem; 2000 Oct; 43(21):3852-61. PubMed ID: 11052790
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The tail wagging the dog: insights into catalysis in R67 dihydrofolate reductase.
    Kamath G; Howell EE; Agarwal PK
    Biochemistry; 2010 Oct; 49(42):9078-88. PubMed ID: 20795731
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Methotrexate and folate binding to dihydrofolate reductase. Separate characterization of the pteridine and p-aminobenzoyl binding sites by resonance Raman spectroscopy.
    Ozaki Y; King RW; Carey PR
    Biochemistry; 1981 May; 20(11):3219-25. PubMed ID: 7018571
    [TBL] [Abstract][Full Text] [Related]  

  • 20. QM/MM and SCRF studies of the ionization state of 8-methylpterin substrate bound to dihydrofolate reductase: existence of a low-barrier hydrogen bond.
    Cummins PL; Gready JE
    J Mol Graph Model; 2000 Feb; 18(1):42-9. PubMed ID: 10935206
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.